Thomas J Russell

US Patent:

20040023222, Feb 5, 2004

Filed:

Jul 31, 2002

Appl. No.:

10/208939

Inventors:

Thomas Russell - Huntingdon Valley PA, US
Pauline McGann - Miami Beach FL, US
Mike Musick - Mason OH, US
Michael Ciocci - Royersfored PA, US

International Classification:

C12Q001/68
G01N033/53
G01N033/567
G01N033/553

US Classification:

435/006000, 435/007200, 435/007500, 436/526000

Abstract:

Methods, apparatus and compositions for separating a desired or undesired population or subpopulation from a biological sample are disclosed herein. The selection procedure is based on ferromagnetic, dense particles in a preferred size range from about 0.8 to about 1.2 microns. Specific binding agents are bound to the particles that recognize and bind to specific molecules on the targeted population or subpopulation, and the particles are mixed with the sample in such a way as to promote movement of the particles relative to the sample, promoting binding to the targeted population or subpopulation without non-specifically binding to non-targeted populations in the sample. Because of the large particle density, the bound population is separated from the fluid sample by gravity. Alternatively, the sample, including the bound, targeted population, is placed in a magnetic field such that the particles separate from the sample by evenly distributing over the vessel wall thus limiting non-specific trapping of the non-targeted population.

US Patent:

20060003371, Jan 5, 2006

Filed:

Jun 23, 2005

Appl. No.:

11/159957

Inventors:

Thomas Russell - Huntingdon Valley PA, US
Michael Ciocci - Royersford PA, US
Michael Musick - Mason OH, US

Assignee:

Russell Biotech, Inc. - Huntingdon Valley PA

International Classification:

C12Q 1/68
G01N 33/551

US Classification:

435006000, 436524000

Abstract:

Coated Ferromagnetic Density Particles or Density Particles with binding agents bound thereto capable of binding biological molecules and methods of use and apparatus for means are disclosed. Coated particles coupled to specific binding agents can be used for molecular biology and proteomic applications in research and diagnostics.

US Patent:

53331800, Jul 26, 1994

Filed:

Sep 23, 1991

Appl. No.:

7/763487

Inventors:

Percy B. Brown - East Brunswick NJ
Nga V. Chau - Middletown NJ
Tung-Hai K. Hsiao - Freehold NJ
Georg K. Karawas - West Long Branch NJ
Richard E. LeCronier - New Monmouth NJ
Dawn R. Parrott - Neptune NJ
Thomas L. Russell - Colts Neck NJ
Wen-Ping Ying - East Brunswick NJ

Assignee:

AT&T Bell Laboratories - Murray Hill NJ

International Classification:

H04M 164

US Classification:

379 89

Abstract:

A Call Message Delivery System (CDS) in response to a request from a caller to deliver an international voice call message, uses the country code digits of the called station number to select the language to be used in the system announcement which precedes the delivery of the caller's message to the called station. Another feature enables the caller to select a system announcement to be delivered with the call message. An additional feature enables the caller to record his or her own announcement as the system announcement.

US Patent:

56001460, Feb 4, 1997

Filed:

Nov 22, 1995

Appl. No.:

8/561906

Inventors:

Joseph A. Felker - Belle Mead NJ
Thomas C. Russell - Murray Hill NJ

Assignee:

Lucent Technologies Inc. - Murray Hill NJ

International Classification:

H01J 37147

US Classification:

250396R

Abstract:

Circuitry that controls a multiple-plate charged particle beam deflection arrangement includes a Digital Signal Processor (DSP) acting through a separate accumulating Arithmetic Logic Unit (ALU) connected to each of the plates. For each line to be scanned, at the commencement of the scanning of the line, the DSP delivers to each accumulating ALU a separate signal composed of a digital number representing an initial value (if any) and a digital number representing a step size. During each subsequent cycle of a clock, each accumulating ALU successively adds the step size to a resulting cumulative sum. This cumulative sum depends upon the initial value (if any) plus the step size multiplied by the number of cycles that have elapsed since the initial cycle.

US Patent:

49397710, Jul 3, 1990

Filed:

Sep 20, 1989

Appl. No.:

7/410556

Inventors:

Percy B. Brown - East Brunswick NJ
Nga V. Chau - Middletown NJ
A. R. Gore - Eatontown NJ
Tung-Hai Hsiao - Freehold NJ
Georg K. Karawas - West Long Branch NJ
Richard E. LeCronier - New Monmouth NJ
Dawn R. Parrott - Neptune NJ
Usha Rao - Piscataway NJ
Thomas L. Russell - Colts Neck NJ
Wen-Ping Ying - East Brunswick NJ

Assignee:

AT&T Bell Laboratories - Murray Hill NJ

International Classification:

H04M 350

US Classification:

379 67

Abstract:

A Call Message Delivery system (CDS) enables an attendant to control the delivery of a recorded call message from a caller to a specified party at a called station. The CDS alerts the attendant at a delivery time, selected by either the caller or the system. When the attendant determines that the specified party has answered the call at the called station, the caller's recorded call message is outputted to the specified party. If the specified party is not available, the attendant may schedule the call for a later delivery or may forward the call to another station specified by the answering party at the called station.

US Patent:

49724614, Nov 20, 1990

Filed:

Sep 20, 1989

Appl. No.:

7/410559

Inventors:

Percy B. Brown - East Brunswick NJ
Nga V. Chau - Middletown NJ
Tung-Hai Hsiao - Freehold NJ
Georg K. Karawas - West Long Branch NJ
Richard E. LeCronier - New Monmouth NJ
Dawn R. Parrott - Neptune NJ
Thomas L. Russell - Colts Neck NJ
Wen-Ping Ying - East Brunswick NJ

Assignee:

AT&T Bell Laboratories - Murray Hill NJ

International Classification:

H04M 350
H04M 1512

US Classification:

379 67

Abstract:

A call delivery service (CDS) apparatus and method are disclosed which enable non-subscriber callers to a common carrier network to bill a voice message delivery to their billing code, and to check the delivery status of the message from the network during a subsequent call. Optionally, at the caller's request, CDS can deliver the message status to the caller at a predesignated station. In one embodiment the caller can optionally request a response from the message recipient or answering party at the called station.

US Patent:

20220195414, Jun 23, 2022

Filed:

Mar 24, 2020

Appl. No.:

17/600432

Inventors:

- Doylestown PA, US
Thomas Russell - Doylestown PA, US

Assignee:

Russell Biotech, Inc. - Doylestown PA

International Classification:

C12N 13/00

Abstract:

CAR T cell therapies have shown promise in treating human blood cell cancer. The preparation of CAR T cells involves many complex, time consuming steps prior to infusion of the CAR T cells into a cancer patient. One step in the process to create CAR T cells often involves using magnetic separation technologies to isolate specific subsets of T cells prior to creating the CAR T cells. When using current magnetic separation technologies to remove undesired cell populations the recovery of the desired cell population can be as low as 50-70% or even lower and the procedures often take 30-60 minutes. In the case of autologous CAR T cell therapies such cell loss is often not acceptable. The present invention offers means to improve the recovery of desired cells to close to 100% very rapidly thus significantly improving a step in the manufacture of CART cells and in many cases will make such therapy possible for a larger patient population.