Thomas R Ziegler

US Patent:

6335317, Jan 1, 2002

Filed:

Apr 9, 1999

Appl. No.:

09/289259

Inventors:

Thomas R. Ziegler - Lilburn GA
Dean P. Jones - Decatur GA

Assignee:

Emory University - Atlanta GA

International Classification:

A61K 3818

US Classification:

514 12, 530324

Abstract:

The present disclosure describes methods for minimizing oxidative damage in an animal or human during or after malnutrition, underfeeding or fasting, especially during refeeding after undernutrition or malnutrition, and for minimizing oxidant damage during or after toxicity resulting from chemotherapy, alcoholism, irradiation therapy or chemical or environmental exposure to a toxic compound. Administration of an effective amount of a gut trophic growth factor (GTGF) effective for improving gut and/or systemic antioxidant status results in improved clinical condition and/or outcome for the patient or animal to which the GTGF has been administered. In the context of the present disclosure, GTGF includes fibroblast growth factors, keratinocyte growth factor, hepatocyte growth factor, insulin-like growth factor I, glucagon, glicentin, and glucagon-like peptide.

US Patent:

8067537, Nov 29, 2011

Filed:

Sep 2, 2005

Appl. No.:

11/574682

Inventors:

Satoru Furukawa - Tokyo, JP
Kenjiro Shimada - Ibaraki, JP
Dean Jones - Atlanta GA, US
Thomas Ziegler - Lilburn GA, US

Assignee:

Kyowa Hakko Bio Co., Ltd. - Tokyo
Emory University - Atlanta GA

International Classification:

A61K 38/06

US Classification:

530331, 514247, 514 219

Abstract:

A composition and a method effective in preventing or treating stomatitis are presented. The composition contains glutathione or a pharmaceutically acceptable salt thereof and/or orotic acid or a derivative thereof or a pharmaceutically acceptable salt thereof is provided.

US Patent:

62288393, May 8, 2001

Filed:

Dec 18, 1998

Appl. No.:

9/216637

Inventors:

Thomas R. Ziegler - Lilburn GA
Dean P. Jones - Decatur GA

Assignee:

Emory University - Atlanta GA

International Classification:

A61K 3818

US Classification:

514 12

Abstract:

The present disclosure provides methods for minimizing oxidative damage in an animal or human during or after malnutrition, underfeeding or fasting, especially during refeeding after undernutrition or malnutrition, and for minimizing oxidant damage during or after toxicity resulting from chemotherapy, alcoholism, irradiation therapy or chemical or environmental exposure. The present methods comprise the step of administering an amount of keratinocyte growth factor effective for improving gut and/or systemic antioxidant status.