Tian W Zhang

US Patent:

20180231560, Aug 16, 2018

Filed:

Sep 15, 2015

Appl. No.:

15/511229

Inventors:

- Durham NC, US
- Raritan NJ, US
Rengasamy BOOMINATHAN - Elkins Park PA, US
Tian Zhang - Durham NC, US
Mariano A. Garcia-Blanco - Galveston TX, US
Andrew J. Armstrong - Chapel Hill NC, US

International Classification:

G01N 33/574
C07K 16/30
C07K 16/28

Abstract:

This disclosure provides compositions and methods for the isolation of cells that express c-MET, and in particular circulating tumor cells that express c-MET. The methods can include contacting a biological sample including a c-MET circulating tumor cell with an unbound complex including a capture binding species linked to a solid phase for a time sufficient to allow the unbound complex to bind an extracellular binding domain of the c-MET protein to form a bound complex, and subsequently isolating the bound complex. Compositions, systems, and kits adapted for use with these methods are also provided.