Timothy M Briggs

US Patent:

20100152099, Jun 17, 2010

Filed:

Aug 20, 2009

Appl. No.:

12/544604

Inventors:

Jinbo Lee - Andover MA, US
Julian F. Bond - Weymouth MA, US
Nicholas Terrett - Sherborn MA, US
Daniel Wang - Duxbury MA, US
Timothy F. Briggs - Cambridge MA, US
Benjamin A. Seigal - Watertown MA, US
Wei-Chuan Sun - Menlo Park CA, US
Stephen P. Hale - Belmont MA, US

International Classification:

A61K 38/12
C07K 5/12
A61P 19/02
A61P 1/00
A61P 35/00
A61P 3/10
A61P 25/28

US Classification:

514 9, 530317

Abstract:

The invention provides macrocyclic compounds and methods for their synthesis and use. In particular, the invention provides macrocyclic compounds that modulate the activity of tumor necrosis factor alpha and/or are useful in the treatment of medical conditions, such as, rheumatoid arthritis, psoriasis, and asthma.

US Patent:

20220296555, Sep 22, 2022

Filed:

Jun 3, 2022

Appl. No.:

17/831562

Inventors:

- Cambridge MA, US
David Arthur BERRY - Newton MA, US
Timothy F. BRIGGS - Waltham MA, US
Leonard BUCKBINDER - East Greenwich RI, US
Mi-Jeong KIM - Boston MA, US
Anna LIANG - Everett MA, US
Anushya PANDIAN - Acton MA, US

International Classification:

A61K 31/222
A61K 31/192
A61K 31/352
A61K 31/7012
A61P 3/10
A61P 3/04

Abstract:

Disclosed herein are acylated active agents, compositions containing them, unit dosage forms containing them, and methods of their use, e.g., for treating a metabolic disorder or nonalcoholic fatty liver disease or for modulating a metabolic marker or nonalcoholic fatty liver disease marker.

US Patent:

20220296563, Sep 22, 2022

Filed:

Jun 3, 2022

Appl. No.:

17/831535

Inventors:

- Cambridge MA, US
David Arthur BERRY - Newton MA, US
Timothy F. BRIGGS - Waltham MA, US
Leonard BUCKBINDER - East Greenwich RI, US
Mi-Jeong KIM - Boston MA, US
Anna LIANG - Everett MA, US

International Classification:

A61K 31/353
A61K 31/225
A61K 31/7004
A61P 1/16

Abstract:

Disclosed herein are acylated active agents (e.g., acylated hydroxybenzoic acid), compositions containing them, unit dosage forms containing them, and methods of their use, e.g., for treating a metabolic disorder or nonalcoholic fatty liver disease or for modulating a metabolic marker or nonalcoholic fatty liver disease marker.

US Patent:

20210381665, Dec 9, 2021

Filed:

Nov 7, 2018

Appl. No.:

16/645771

Inventors:

- Malvern PA, US
Simon Bobbo - Milan, IT
Matteo Caldon - Milan, IT
Roberta Frare - Milan, IT
Lorenzo Baldo - Milan, IT
Eleonora Pappalardo - Milan, IT
Alessandro Scordino - Milan, IT
Francesca Peruzzo - Milan, IT
Werner De Groodt - Milan, IT
Kim Dupont-Madinier - Somerville MA, US
Timothy Briggs - Clinton MA, US

International Classification:

F21S 8/04
F21V 8/00
F21V 7/05
E04B 9/00
E04B 9/06

Abstract:

Lighting device () for a false ceiling () comprising a plurality of T-profiles () having respective longitudinal axes (A) and arranged in a square mesh grid (), in which each T-profile () has a lower wall with a width (W) and in which the grid () has a center distance (D) between the longitudinal axes (A) of T-profiles () parallel and adjacent to one another, in which the lighting device () has an elongated parallelepiped shape with a width (W′) comparable to the width (W) of said T-profiles (), a height (h) of less than 15 mm and a length (D′) comparable to said center distance (D) between the longitudinal axes (A) of T-profiles () parallel and adjacent to one another, and in which said lighting device () is capable of being fitted directly in contact with the lower wall of a respective T-profile ().

US Patent:

20210372903, Dec 2, 2021

Filed:

Jun 21, 2019

Appl. No.:

17/253874

Inventors:

- Malvern PA, US
Timothy Briggs - Clinton MA, US

International Classification:

G01N 9/00

Abstract:

The present disclosure relates to devices and methods for determining the density of insulation. For example, one aspect of the disclosure is a device that includes a first unit that includes a sound generator and a second unit that includes a sound sensor and a probe. The probe is configured to be inserted into insulation such that the sound sensor is outside of the insulation and is configured to detect sound that is generated by the sound generator outside of the insulation and transmitted through the insulation and the probe to the sound sensor. The device also includes a control system configured to cause the sound generator to generate the sound and to use the sound detected by the sound sensor to generate output that represents the density of the insulation.

US Patent:

20210299079, Sep 30, 2021

Filed:

Jun 3, 2021

Appl. No.:

17/337595

Inventors:

- Cambridge MA, US
David Arthur BERRY - Newton MA, US
Jessica Elizabeth ALEXANDER - Waltham MA, US
Timothy BRIGGS - Waltham MA, US
Leonard BUCKBINDER - East Greenwich RI, US
Dinara Shashanka GUNASEKERA - Cambridge MA, US
Afrand KAMALI SARVESTANI - Somerville MA, US
Mi-Jeong KIM - Boston MA, US
Bernard LANTER - Somerville MA, US
Anna LIANG - Everett MA, US
Kathleen NUDEL - Jamaica Plain MA, US
Spencer Cory PECK - Watertown MA, US
Cheri ROSS - Winthrop MA, US
Steven John TAYLOR - Winchester MA, US
Koji YASUDA - Boston MA, US

International Classification:

A61K 31/225
A61K 47/54
A61P 25/28
A61P 37/06

Abstract:

Disclosed are conjugates of monomethyl fumarate and a carrier group or aminocarrier group, or a pharmaceutically acceptable salt thereof. In the conjugates, monomethyl fumarate acyl is covalently bonded to the carrier group or aminocarrier group through a carbon-oxygen bond that is cleavable in vivo. The carrier group may include a core, e.g., a monosaccharide, a sugar acid (e.g., acid monosaccharide), a sugar alcohol, or a catechin polyphenol. The aminocarrier group may include a core, e.g., an aminomonosaccharide. The carrier group or aminocarrier group may include, e.g., at least one short chain fatty acid acyl, at least one tryptophan analogue, at least one ketone body, or at least one pre-ketone body. Also disclosed are pharmaceutical compositions containing the conjugates and methods of their use.

US Patent:

20210283157, Sep 16, 2021

Filed:

May 13, 2021

Appl. No.:

17/319285

Inventors:

- Cambridge MA, US
Mi-Jeong KIM - Boston MA, US
Kathleen NUDEL - Jamaica Plain MA, US
Timothy F. BRIGGS - Waltham MA, US
Koji YASUDA - Boston MA, US
Leonard BUCKBINDER - East Greenwich RI, US
Bernard LANTER - Somerville MA, US
Spencer Cory PECK - Watertown MA, US
Cheri SNEDEKER - Boston MA, US
Angela SHE - Cambridge MA, US
Jessica ALEXANDER - Waltham MA, US
Anna LIANG - Everett MA, US
Jenny LIU - Cambridge MA, US
Dinara GUNASEKERA - Cambridge MA, US
David Arthur BERRY - Waban MA, US
John Patrick CASEY, JR. - Boston MA, US
Amir H. MOAREFI - Encino CA, US

International Classification:

A61K 31/7036
A61P 37/06
A61K 9/00
A61K 31/191
A61K 31/196
A61K 31/353
A61K 31/519

Abstract:

Disclosed herein are acylated active agents and methods of their use, e.g., for modulating an autoimmunity marker or for treating an autoimmune disorder.

US Patent:

20200188418, Jun 18, 2020

Filed:

Feb 27, 2020

Appl. No.:

16/803284

Inventors:

- Cambridge MA, US
Mi-Jeong KIM - Boston MA, US
Kathleen NUDEL - Jamaica Plain MA, US
Timothy F. BRIGGS - Waltham MA, US
Koji YASUDA - Boston MA, US
Leonard BUCKBINDER - East Greenwich RI, US
Bernard LANTER - Somerville MA, US
Spencer Cory PECK - Watertown MA, US
Cheri SNEDEKER - Boston MA, US
Angela SHE - Cambridge MA, US
Jessica ALEXANDER - Waltham MA, US
Anna LIANG - Everett MA, US
Jenny LIU - Cambridge MA, US
Dinara GUNASEKERA - Cambridge MA, US
David Arthur BERRY - Waban MA, US
John Patrick CASEY, JR. - Boston MA, US

International Classification:

A61K 31/7036
A61K 9/00
A61K 31/196
A61K 31/191
A61K 31/353
A61K 31/519
A61P 37/06

Abstract:

Disclosed herein are acylated active agents and methods of their use, e.g., for modulating an autoimmunity marker or for treating an autoimmune disorder.