Thomas W. Hudyma - Durham CT, US Xiaofan Zheng - Cheshire CT, US B. Narasimhulu Naidu - Durham CT, US Margaret E. Sorenson - Meriden CT, US Alicia Regueiro-Ren - Middletown CT, US Timothy P. Connolly - Middletown CT, US John D. Matiskella - Wallingford CT, US Oak K. Kim - Cambridge MA, US Yunhui Zhang - Glastonbury CT, US Dane M. Springer - North Haven CT, US Jason Goodrich - Meriden CT, US Yasutsugu Ueda - Clinton CT, US Joanne J. Bronson - Durham CT, US
Assignee:
Bristol-Myers Squibb Company - Princeton NJ
International Classification:
A61K 38/16
US Classification:
514 8, 514 9, 530317
Abstract:
The present invention provides compounds of formula I having potent antibiotic activity, including activity towards Gram-positive bacteria and mycobacteria.
B. Narasimhulu Naidu - Durham CT, US Jacques Banville - St-Hubert, CA Francis Beaulieu - Laprairie, CA Timothy P. Connolly - Portland CT, US Mark R. Krystal - Westport CT, US John D. Matiskella - Wallingford CT, US Carl Ouellet - Boucherville, CA Serge Plamondon - Ste-Catherine, CA Roger Remillard - Napierville, CA Margaret E. Sorenson - Meriden CT, US Yasutsugu Ueda - Clinton CT, US Michael A. Walker - Durham CT, US
The invention encompasses a series bicyclic pyrimidinone compounds of Formula I which inhibit HIV integrase and prevent viral integration into human DNA. This action makes the compounds useful for treating HIV infection and AIDS. The invention also encompasses pharmaceutical compositions and methods for treating those infected with HIV.
B. Narasimhulu Naidu - Durham CT, US Jacques Banville - St-Hubert, CA Francis Beaulieu - Laprairie, CA Timothy P. Connolly - Portland CT, US Mark R. Krystal - Westport CT, US John D. Matiskella - Wallingford CT, US Carl Ouellet - Boucherville, CA Serge Plamondon - Ste-Catherine, CA Roger Remillard - Napierville, CA Margaret E. Sorenson - Meriden CT, US Yasutsugu Ueda - Clinton CT, US Michael A. Walker - Durham CT, US
The invention encompasses a series cyclic bicyclic pyrimidinone compounds of Formula I which inhibit HIV integrase and prevent viral integration into human DNA. This action makes the compounds useful for treating HIV infection and AIDS. The invention also encompasses pharmaceutical compositions and methods for treating those infected with HIV.
Hiv Integrase Inhibitors: Cyclic Pyrimidinone Compounds
The invention encompasses a series of pyrimidinone compounds which inhibit HIV integrase and thereby prevent viral integration into human DNA. This action makes the compounds useful for treating HIV infection and AIDS. The invention also encompasses intermediates useful for making the pyrimidone compounds. Additionally, pharmaceutical compositions and methods for treating those infected with HIV are encompassed.
N-[[4-Fluoro-2-(5-Methy-1H-1,2,4-Triazol-1-Yl)Phenyl]Methyl]-4-,6,7,9-Tetrahydro-3-Hydroxy-9,9-Dimethyl-4-Oxo-Pyrimido[2,1-C][1,4]Oxazine-2-Carboxamide As An Hiv Integrase Inhibitor
B. Narasimhulu Naidu - Durham CT, US Jacques Banville - St-Hubert, CA Francis Beaulieu - Laprairie, CA Timothy P. Connolly - Portland CT, US Mark R. Krystal - Westport CT, US John D. Matiskella - Wallingford CT, US Carl Ouellet - Boucherville, CA Serge Plamondon - Ste-Catherine, CA Roger Remillard - Napierville, CA Margaret E. Sorenson - Meriden CT, US Yasutsugu Ueda - Clinton CT, US Michael A. Walker - Durham CT, US
The invention encompasses a series of bicyclic pyrimidinone compounds of Formula I which inhibit HIV integrase and prevent viral integration into human DNA. This action makes the compounds useful for treating HIV infection and AIDS. The invention also encompasses pharmaceutical compositions and methods for treating those infected with HIV.
Francis Beaulieu - Quebec, CA Carl Ouellet - Boucherville, CA B. Narasimhulu Naidu - Durham CT, US Manoj Patel - Berlin CT, US Yasutsugu Ueda - Clinton CT, US Timothy P. Connolly - Portland CT, US Jonathan R. Weiss - Boston MA, US Michael A. Walker - Durham CT, US Nicholas A. Meanwell - East Hampton CT, US Kevin M. Peese - Haddam CT, US Margaret E. Sorenson - Meriden CT, US Chen Li - South Glastonbury CT, US
Assignee:
Bristol-Myers Squibb Company - Princeton NJ
International Classification:
A61K 31/505 C07D 487/12
US Classification:
514267, 544252
Abstract:
The disclosure generally relates to the novel compounds of formula I, including their salts, which inhibit HIV integrase and prevent viral integration into human DNA. This action makes the compounds useful for treating HIV infection and AIDS. The invention also encompasses pharmaceutical compositions and methods for treating those infected with HIV.
B. Naidu - Durham CT, US Wenying Li - Middletown CT, US Kin Lam - North Haven CT, US Margaret Sorenson - Meriden CT, US John Wichtowski - Deep River CT, US Timothy Connolly - Meriden CT, US Yasutsugu Ueda - Clinton CT, US Joanne Bronson - Durham CT, US Yunhui Zhang - Glastonbury CT, US Oak Kim - Milford CT, US
International Classification:
A61K038/12 C07K007/50
US Classification:
514/009000, 530/317000, 540/456000
Abstract:
Novel thiazolyl peptide compounds useful for the treatment of serious bacterial infections, and pharmaceutical compositions thereof are provided. More particularly, novel thiazolyl peptide compounds are provided having the general formula I: wherein Q, Y and R′ areas defined in the specification.
The invention encompasses a series bicyclic pyrimidinone compounds of Formula I which inhibit HIV integrase and prevent viral integration into human DNA. This action makes the compounds useful for treating HIV infection and AIDS. The invention also encompasses pharmaceutical compositions and methods for treating those infected with HIV.
Dr. Connolly graduated from the Georgetown University School of Medicine in 1998. He works in Houston, TX and specializes in Pulmonary Critical Care Medicine and Sleep Medicine. Dr. Connolly is affiliated with Baylor St Lukes Medical Center and Houston Methodist Hospital.
Name / Title
Company / Classification
Phones & Addresses
Timothy J. Connolly Director
Hdr Environmental, Operations and Construction, Inc Business Consulting Services · Engineering Services & Environmental Consultant
(610)9499699, (916)8527792, (830)4384720
Timothy Connolly Principal
Tim Connolly Builders Single-Family House Construction
Disaster Preparedness & Response Consultant at United Natons & Non-Governmental Organizations
Location:
Madison, Wisconsin Area
Industry:
Non-Profit Organization Management
Work:
United Natons & Non-Governmental Organizations since Nov 1996
Disaster Preparedness & Response Consultant
United Nations World Food Programme (WFP) - Kathmandu, Nepal Aug 2009 - Oct 2009
Multinational Planning Augmentation Team (MPAT) Program Consultant
United Nations World Food Programme (WFP) - Kathmandu, Nepal Apr 2008 - Jun 2008
Emergency Logistics Contingency Planner Consultant
Mines Advisory Group (MAG) Aug 2007 - Feb 2008
Sudan Country Manager
Mines Advisory Group (MAG) Jan 2007 - Jul 2007
Iraq Community Liaison Manager
Education:
University of Wisconsin-Madison 2010 - 2012
Masters, Public Health
Queen Mary, U. of London 2007 - 2012
Postgraduate Diploma in Laws, International Humanitarian & Human Rights Law
The New School for Social Research 1997 - 1998
Masters, Masters of Science in Teaching
Vassar College 1974 - 1978
AB, Political Science
2012 to 2000 Health Insurance BrokerColonial Life Insurance Co
2010 to 2000 Agency Sales RepresentativeHudson Eagle Distributing Co Jersey City, NJ 1999 to 2001 Sales Team LeaderScampi's Restaurant Somerville, NJ 1998 to 1999 General ManagerRitter Sysco Food Services Jersey City, NJ 1995 to 1998 Sales Representative
Education:
University of LaVerne 1993 to 1995 Bachelor of Arts
1998 to Present GENERAL MANAGERAAMCO Transmission Oakland, CA 1996 to 1998 CUSTOMER SERVICE MANAGERAAMCO Corporate Franchise Services, New York, AZ 1994 to 1996 MANAGEMENT CONSULTANT
Education:
Iona College New Rochelle, NY 1989 Bachelor of Arts in Economics
Tim’s interest and study of non-mainstream subject matter including esoteric topics begun at the age of 14. Being forever inquisitive by nature has quickly lead him to higher levels of awareness and a...