Timothy P Connolly

US Patent:

6448401, Sep 10, 2002

Filed:

Oct 16, 2001

Appl. No.:

09/982199

Inventors:

Chung-Pin Chen - Madison CT
Timothy Paul Connolly - Meriden CT
Laxma Reddy Kolla - Rocky Hill CT
John D. Matiskella - Wallingford CT
Richard H. Mueller - Ringoes NJ
Yadagiri Pendri - South Glastonbury CT
Dejah T. Petsch - Mansfield Center CT

Assignee:

Bristol-Myers Squibb Company - Princeton NJ

International Classification:

C07F 902

US Classification:

544243, 544337, 548112, 558 87

Abstract:

An improved process is provided for preparing water-soluble prodrugs of triazole antifungal compounds containing a secondary or tertiary hydroxyl group. More particularly, the improved process is directed toward preparation of water-soluble triazole antifungal compounds are provided having the general formula wherein A is the non-hydroxy portion of a triazole antifungal compound of the type containing a secondary or tertiary hydroxyl group and R and R are as defined in the specification.

US Patent:

7022667, Apr 4, 2006

Filed:

Jul 3, 2002

Appl. No.:

10/189710

Inventors:

Thomas W. Hudyma - Durham CT, US
Xiaofan Zheng - Cheshire CT, US
B. Narasimhulu Naidu - Durham CT, US
Margaret E. Sorenson - Meriden CT, US
Alicia Regueiro-Ren - Middletown CT, US
Timothy P. Connolly - Middletown CT, US
John D. Matiskella - Wallingford CT, US
Oak K. Kim - Cambridge MA, US
Yunhui Zhang - Glastonbury CT, US
Dane M. Springer - North Haven CT, US
Jason Goodrich - Meriden CT, US
Yasutsugu Ueda - Clinton CT, US
Joanne J. Bronson - Durham CT, US

Assignee:

Bristol-Myers Squibb Company - Princeton NJ

International Classification:

A61K 38/16

US Classification:

514 8, 514 9, 530317

Abstract:

The present invention provides compounds of formula I having potent antibiotic activity, including activity towards Gram-positive bacteria and mycobacteria.

US Patent:

7157447, Jan 2, 2007

Filed:

Nov 29, 2005

Appl. No.:

11/288533

Inventors:

B. Narasimhulu Naidu - Durham CT, US
Jacques Banville - St-Hubert, CA
Francis Beaulieu - Laprairie, CA
Timothy P. Connolly - Portland CT, US
Mark R. Krystal - Westport CT, US
John D. Matiskella - Wallingford CT, US
Carl Ouellet - Boucherville, CA
Serge Plamondon - Ste-Catherine, CA
Roger Remillard - Napierville, CA
Margaret E. Sorenson - Meriden CT, US
Yasutsugu Ueda - Clinton CT, US
Michael A. Walker - Durham CT, US

Assignee:

Bristol-Myers Squibb Company - Princeton NJ

International Classification:

C07K 33/42
C07D 267/14
C07D 279/02
C07D 205/08
C07F 90/542
A61K 31/533

US Classification:

514 80, 540552, 540542, 540362, 540524, 5142111, 5142305, 544105, 544 3

Abstract:

The invention encompasses a series bicyclic pyrimidinone compounds of Formula I which inhibit HIV integrase and prevent viral integration into human DNA. This action makes the compounds useful for treating HIV infection and AIDS. The invention also encompasses pharmaceutical compositions and methods for treating those infected with HIV.

US Patent:

7176196, Feb 13, 2007

Filed:

May 11, 2005

Appl. No.:

11/126891

Inventors:

B. Narasimhulu Naidu - Durham CT, US
Jacques Banville - St-Hubert, CA
Francis Beaulieu - Laprairie, CA
Timothy P. Connolly - Portland CT, US
Mark R. Krystal - Westport CT, US
John D. Matiskella - Wallingford CT, US
Carl Ouellet - Boucherville, CA
Serge Plamondon - Ste-Catherine, CA
Roger Remillard - Napierville, CA
Margaret E. Sorenson - Meriden CT, US
Yasutsugu Ueda - Clinton CT, US
Michael A. Walker - Durham CT, US

Assignee:

Bristol-Myers Squibb Company - Princeton NJ

International Classification:

C07D 498/04
C07D 205/08
A61K 31/5365
A61K 31/553
A61K 31/397
A61K 31/675
A61K 31/18
A61P 31/18

US Classification:

5142111, 540552, 540362, 51421002, 5142305, 514 80, 544105

Abstract:

The invention encompasses a series cyclic bicyclic pyrimidinone compounds of Formula I which inhibit HIV integrase and prevent viral integration into human DNA. This action makes the compounds useful for treating HIV infection and AIDS. The invention also encompasses pharmaceutical compositions and methods for treating those infected with HIV.

US Patent:

7419969, Sep 2, 2008

Filed:

Nov 14, 2005

Appl. No.:

11/273671

Inventors:

B. Narasimhulu Naidu - Durham CT, US
Timothy P. Connolly - Portland CT, US
Yasutsugu Ueda - Clinton CT, US

Assignee:

Bristol-Myers Squibb Company - Princeton NJ

International Classification:

C07F 9/40
C07D 267/08
C07D 487/10
C07D 265/28
A61K 31/665
A61K 31/553
A61K 31/505
A61K 31/527
A61K 31/535
A61K 31/537

US Classification:

514 81, 51421112, 514267, 5142302, 544230, 544 70, 544 71, 540542, 540543

Abstract:

The invention encompasses a series of pyrimidinone compounds which inhibit HIV integrase and thereby prevent viral integration into human DNA. This action makes the compounds useful for treating HIV infection and AIDS. The invention also encompasses intermediates useful for making the pyrimidone compounds. Additionally, pharmaceutical compositions and methods for treating those infected with HIV are encompassed.

US Patent:

7511037, Mar 31, 2009

Filed:

Aug 16, 2006

Appl. No.:

11/505149

Inventors:

B. Narasimhulu Naidu - Durham CT, US
Jacques Banville - St-Hubert, CA
Francis Beaulieu - Laprairie, CA
Timothy P. Connolly - Portland CT, US
Mark R. Krystal - Westport CT, US
John D. Matiskella - Wallingford CT, US
Carl Ouellet - Boucherville, CA
Serge Plamondon - Ste-Catherine, CA
Roger Remillard - Napierville, CA
Margaret E. Sorenson - Meriden CT, US
Yasutsugu Ueda - Clinton CT, US
Michael A. Walker - Durham CT, US

Assignee:

Bristol-Myers Squibb Company - Princeton NJ

International Classification:

A61K 31/5365
A61K 38/16
A61K 35/76
A61K 31/5513
A61K 31/662
A61P 31/18
C07D 498/04

US Classification:

5142305, 514 12, 514220, 514117, 514 81, 544105

Abstract:

The invention encompasses a series of bicyclic pyrimidinone compounds of Formula I which inhibit HIV integrase and prevent viral integration into human DNA. This action makes the compounds useful for treating HIV infection and AIDS. The invention also encompasses pharmaceutical compositions and methods for treating those infected with HIV.

US Patent:

7745625, Jun 29, 2010

Filed:

Feb 25, 2005

Appl. No.:

11/066745

Inventors:

Yasutsugu Ueda - Clinton CT, US
Timothy P. Connolly - Portland CT, US
John F. Kadow - Wallingford CT, US
Nicholas A. Meanwell - East Hampton CT, US
Tao Wang - Middletown CT, US
Chung-Pin H. Chen - Madison CT, US
Kap-Sun Yeung - Madison CT, US
Zhongxing Zhang - Madison CT, US
David Kenneth Leahy - Somerset NJ, US
Shawn K. Pack - Plainsboro NJ, US
Nachimuthu Soundararajan - Kendall Park NJ, US
Pierre Sirard - St. Jean sur Richelieu, CA
Kathia Levesque - Ste-Catherine, CA
Dominique Thoraval - Candiac, CA

Assignee:

Bristol-Myers Squibb Company - Princeton NJ

International Classification:

C07D 401/00

US Classification:

544362

Abstract:

This invention provides for prodrug Compounds I, pharmaceutical compositions thereof, and their use in treating HIV infection. Also, this invention provides for intermediate Compounds II useful in making prodrug Compounds I.

US Patent:

8129398, Mar 6, 2012

Filed:

Mar 18, 2009

Appl. No.:

12/406268

Inventors:

Francis Beaulieu - Quebec, CA
Carl Ouellet - Boucherville, CA
B. Narasimhulu Naidu - Durham CT, US
Manoj Patel - Berlin CT, US
Yasutsugu Ueda - Clinton CT, US
Timothy P. Connolly - Portland CT, US
Jonathan R. Weiss - Boston MA, US
Michael A. Walker - Durham CT, US
Nicholas A. Meanwell - East Hampton CT, US
Kevin M. Peese - Haddam CT, US
Margaret E. Sorenson - Meriden CT, US
Chen Li - South Glastonbury CT, US

Assignee:

Bristol-Myers Squibb Company - Princeton NJ

International Classification:

A61K 31/505
C07D 487/12

US Classification:

514267, 544252

Abstract:

The disclosure generally relates to the novel compounds of formula I, including their salts, which inhibit HIV integrase and prevent viral integration into human DNA. This action makes the compounds useful for treating HIV infection and AIDS. The invention also encompasses pharmaceutical compositions and methods for treating those infected with HIV.