Timothy E Devine

US Patent:

7060287, Jun 13, 2006

Filed:

Jul 26, 2000

Appl. No.:

09/626326

Inventors:

William G. Hubbard - Burlington WI, US
Timothy R. Devine - Whitefish Bay WI, US

Assignee:

Bioform Inc. - San Mateo CA

International Classification:

A61F 2/00
A61F 2/02

US Classification:

424423, 424426, 523114, 523115, 623 1111

Abstract:

A permanent, biocompatible material for soft tissue augmentation. The biocompatible material comprises a matrix of smooth, round, finely divided, substantially spherical particles of a biocompatible ceramic material, close to or in contact with each other, which provide a scaffold or lattice for autogenous, three dimensional, randomly oriented, non-scar soft tissue growth at the augmentation site. The augmentation material can be homogeneously suspended in a biocompatible, resorbable lubricious gel carrier comprising a polysaccharide. This serves to improve the delivery of the augmentation material by injection to the tissue site where augmentation is desired. The augmentation material is especially suitable for urethral sphincter augmentation, for treatment of incontinence, for filling soft tissue voids, for creating soft tissue blebs, for the treatment of unilateral vocal cord paralysis, and for mammary implants. It can be injected intradermally, subcutaneously or can be implanted.

US Patent:

20020151466, Oct 17, 2002

Filed:

Feb 27, 2002

Appl. No.:

10/084035

Inventors:

William Hubbard - Burlington WI, US
Timothy Devine - Whitefish Bay WI, US

International Classification:

A61K038/18
A61K031/715

US Classification:

514/002000, 514/054000, 514/001000

Abstract:

A permanent, biocompatible material for soft tissue augmentation. The biocompatible material comprises a matrix of smooth, round, finely divided, substantially spherical particles of a biocompatible ceramic material, close to or in contact with each other, which provide a scaffold or lattice for autogenous, three dimensional, randomly oriented, non-scar soft tissue growth at the augmentation site. The augmentation material can be homogeneously suspended in a biocompatible, resorbable lubricious gel carrier comprising a polysaccharide. This serves to improve the delivery of the augmentation material by injection to the tissue site where augmentation is desired. The augmentation material is especially suitable for urethral sphincter augmentation, for treatment of incontinence, for filling soft tissue voids, for creating soft tissue blebs, for the treatment of unilateral vocal cord paralysis, and for mammary implants. It can be injected intradermally, subcutaneously or can be implanted.

US Patent:

20060173551, Aug 3, 2006

Filed:

Mar 14, 2006

Appl. No.:

11/375631

Inventors:

William Hubbard - Burlington WI, US
Timothy Devine - Whitefish Bay WI, US

International Classification:

A61F 2/02

US Classification:

623023720, 623023760, 435397000

Abstract:

A permanent, biocompatible material for soft tissue augmentation. The biocompatible material comprises a matrix of smooth, round, finely divided, substantially spherical particles of a biocompatible ceramic material, close to or in contact with each other, which provide a scaffold or lattice for autogenous, three dimensional, randomly oriented, non-scar soft tissue growth at the augmentation site. The augmentation material can be homogeneously suspended in a biocompatible, resorbable lubricious gel carrier comprising a polysaccharide. This serves to improve the delivery of the augmentation material by injection to the tissue site where augmentation is desired. The augmentation material is especially suitable for urethral sphincter augmentation, for treatment of incontinence, for filling soft tissue voids, for creating soft tissue blebs, for the treatment of unilateral vocal cord paralysis, and for mammary implants. It can be injected intradermally, subcutaneously or can be implanted.

US Patent:

20100240946, Sep 23, 2010

Filed:

May 28, 2010

Appl. No.:

12/790478

Inventors:

William G. Hubbard - Burlington WI, US
Timothy R. Devine - Whitefish Bay WI, US

Assignee:

BIOFORM MEDICAL, INC. - San Mateo, CA

International Classification:

A61F 2/00

US Classification:

600 29

Abstract:

A permanent, biocompatible material for soft tissue augmentation. The biocompatible material comprises a matrix of smooth, round, finely divided, substantially spherical particles of a biocompatible ceramic material, close to or in contact with each other, which provide a scaffold or lattice for autogenous, three dimensional, randomly oriented, non-scar soft tissue growth at the augmentation site. The augmentation material can be homogeneously suspended in a biocompatible, resorbable lubricious gel carrier comprising a polysaccharide. This serves to improve the delivery of the augmentation material by injection to the tissue site where augmentation is desired. The augmentation material is especially suitable for urethral sphincter augmentation, for treatment of incontinence, for filling soft tissue voids, for creating soft tissue blebs, for the treatment of unilateral vocal cord paralysis, and for mammary implants. It can be injected intradermally, subcutaneously or can be implanted.

US Patent:

20110125288, May 26, 2011

Filed:

Jan 27, 2011

Appl. No.:

13/015156

Inventors:

William G. Hubbard - Burlington WI, US
Timothy R. Devine - Whitefish Bay WI, US

Assignee:

MERZ AESTHETICS, INC. - San Mateo CA

International Classification:

A61F 2/02

US Classification:

623 2372

Abstract:

A permanent, biocompatible material for soft tissue augmentation. The biocompatible material comprises a matrix of smooth, round, finely divided, substantially spherical particles of a biocompatible ceramic material, close to or in contact with each other, which provide a scaffold or lattice for autogenous, three dimensional, randomly oriented, non-scar soft tissue growth at the augmentation site. The augmentation material can be homogeneously suspended in a biocompatible, resorbable lubricious gel carrier comprising a polysaccharide. This serves to improve the delivery of the augmentation material by injection to the tissue site where augmentation is desired. The augmentation material is especially suitable for urethral sphincter augmentation, for treatment of incontinence, for filling soft tissue voids, for creating soft tissue blebs, for the treatment of unilateral vocal cord paralysis, and for mammary implants. It can be injected intradermally, subcutaneously or can be implanted.

US Patent:

58075674, Sep 15, 1998

Filed:

Dec 11, 1996

Appl. No.:

8/763021

Inventors:

Donald A. Randolph - Wheaton IL
Jodi L. Negri - Wildwood IL
Timothy R. Devine - Whitefish Bay WI
Steven Gitelis - Mallard Oak Brook IL

Assignee:

Wright Medical Technology, Incorporated - Arlington TN

International Classification:

A61F 202
A61K 916
A61K 950

US Classification:

424426

Abstract:

This invention relates to the controlled release of calcium sulfate as well as to the controlled release of an additive to a calcium sulfate matrix such as medicaments or pesticides. The controlled release is achieved by a pellet comprising calcium sulfate. The pellet is prepared by the process comprising mixing powder consisting essentially of alpha-calcium sulfate hemihydrate, a solution comprising water, and, optionally, an additive and a powder consisting essentially of beta-calcium sulfate hemihydrate to form a mixture, and forming said mixture into a pellet, wherein said alpha-calcium sulfate hemihydrate and beta-calcium sulfate hemihydrate powders have specified properties such as BET surface areas, densities, mean particle sizes, and purities. The dissolution rate of the calcium sulfate pellet is controlled by varying the weight ratio of the beta-calcium sulfate hemihydrate powder to the alpha-calcium sulfate hemihydrate powder from 0 to about 3. The invention also provides a method of delivering medicament in vivo by implanting a pellet prepared with medicament into a human or an animal.

US Patent:

6030636, Feb 29, 2000

Filed:

Sep 2, 1998

Appl. No.:

9/145671

Inventors:

Donald A. Randolph - Wheaton IL
Jodi L. Negri - Lakevilla IL
Timothy R. Devine - Whitefish Bay WI
Steven Gitelis - Oak Brook IL

Assignee:

Wright Medical Technology Incorporated - Arlington TN

International Classification:

A61F 202
A61K 916
A61K 950

US Classification:

424426

Abstract:

This invention relates to the controlled release of calcium sulfate as well as to the controlled release of an additive to a calcium sulfate matrix such as medicaments or pesticides. The controlled release is achieved by a pellet comprising calcium sulfate. The pellet is prepared by the process comprising mixing powder consisting essentially of alpha-calcium sulfate hemihydrate, a solution comprising water, and, optionally, an additive and a powder consisting essentially of beta-calcium sulfate hemihydrate to form a mixture, and forming said mixture into a pellet, wherein said alpha-calcium sulfate hemihydrate and beta-calcium sulfate hemihydrate powders have specified properties such as BET surface areas, densities, mean particle sizes, and purities. The dissolution rate of the calcium sulfate pellet is controlled by varying the weight ratio of the beta-calcium sulfate hemihydrate powder to the alpha-calcium sulfate hemihydrate powder from 0 to about 3. The invention also provides a method of delivering medicament in vivo by implanting a pellet prepared with medicament into a human or an animal.

US Patent:

56142064, Mar 25, 1997

Filed:

Mar 7, 1995

Appl. No.:

8/399769

Inventors:

Donald A. Randolph - Wheaton IL
Jodi L. Negri - Lakevilla IL
Timothy R. Devine - Whitefish Bay WI
Steven Gitelis - Oakbrook IL

Assignee:

Wright Medical Technology, Inc. - Arlington TN

International Classification:

A61F 202
A61K 916
A61K 950

US Classification:

424426

Abstract:

This invention relates to the controlled release of calcium sulfate as well as to the controlled release of an additive to a calcium sulfate matrix such as medicaments or pesticides. The controlled release is achieved by a pellet comprising calcium sulfate. The pellet is prepared by the process comprising mixing powder consisting essentially of alpha-calcium sulfate hemihydrate, a solution comprising water, and, optionally, an additive and a powder consisting essentially of beta-calcium sulfate hemihydrate to form a mixture, and forming said mixture into a pellet, wherein said alpha-calcium sulfate hemihydrate and beta-calcium sulfate hemihydrate powders have specified properties such as BET surface areas, densities, mean particle sizes, and purifies. The dissolution rate of the calcium sulfate pellet is controlled by varying the weight ratio of the beta-calcium sulfate hemihydrate powder to the alpha-calcium sulfate hemihydrate powder from 0 to about 3. The invention also provides a method of delivering medicament in vivo by implanting a pellet prepared with medicament into a human or an animal.