Timothy C Jensen

US Patent:

20070174927, Jul 26, 2007

Filed:

Feb 26, 2005

Appl. No.:

10/591550

Inventors:

Hee-Sook Song - Raleigh NC, US
Christina Roche - Youngsville NC, US
Marc Morra - Bronx NY, US
Christian Dammann - Durham NC, US
Timothy Jensen - Cary NC, US
Alleson Dobson - Cary NC, US

Assignee:

BASF Plant Science GmbH - Ludwigshafen

International Classification:

A01H 1/00
C12N 15/82
C12N 5/04

US Classification:

800278000, 435468000, 435419000

Abstract:

The invention relates to transgenic expression constructs and vectors comprising plant promoters with a non-seed tissue, preferably vegetative plant tissue specific expression profile, and the use of these transgenic expression constructs or vectors for the transgenic expression of nucleic acid sequences in plants. More preferably, the promoters of the invention are the promoter of the ptxA gene, or the promoter of the extensin (SbHRGP3) gene, and functional equivalent fragments and functional equivalent homologs thereof, or their complements, having essentially the same promoter activity. The invention furthermore relates to transgenic plants and plant cells transformed with these expression constructs or vectors, to cultures, parts or propagation material derived therefrom, and to the use of same for the preparation of foodstuffs, animal feeds, seed, pharmaceuticals or fine chemicals, to improve plant biomass, yield, or provide desirable phenotypes.

US Patent:

20180059131, Mar 1, 2018

Filed:

Oct 25, 2017

Appl. No.:

15/792845

Inventors:

- Chapel Hill NC, US
David J. Sloan - Apex NC, US
Timothy C. Jensen - Cary NC, US
Maureen Kay Bunger - Morrisville NC, US

International Classification:

G01N 35/10
B01L 3/00
G01N 33/50

Abstract:

Disclosed are fluidics devices and assemblies allowing for fluid flow between a plurality of wells. The fluidics devices and assemblies that are provided mimic in vivo tissue environments by allowing for initially segregated tissue cultures that can then be linked through fluid flow to measure integrated tissue response. The fluidics devices and assemblies provide a pumpless system using surface tension, gravity, and channel geometries. By linking human tissue functional systems to better simulate in vivo feedback and response signals between the tissues, the need for testing in animals can be minimized.

US Patent:

20170102404, Apr 13, 2017

Filed:

Nov 26, 2016

Appl. No.:

15/361415

Inventors:

- Chapel Hill NC, US
David J. Sloan - Apex NC, US
Timothy C. Jensen - Cary NC, US
Maureen Kay Bunger - Morrisville NC, US

International Classification:

G01N 35/10
G01N 33/50
B01L 3/00

Abstract:

Disclosed are fluidics devices and assemblies allowing for fluid flow between a plurality of wells. The fluidics devices and assemblies that are provided mimic in vivo tissue environments by allowing for initially segregated tissue cultures that can then be linked through fluid flow to measure integrated tissue response. The fluidics devices and assemblies provide a pumpless system using surface tension, gravity, and channel geometries. By linking human tissue functional systems to better simulate in vivo feedback and response signals between the tissues, the need for testing in animals can be minimized.

US Patent:

20160334388, Nov 17, 2016

Filed:

Jun 15, 2016

Appl. No.:

15/183755

Inventors:

- Chapel Hill NC, US
David J. Sloan - Chapel Hill NC, US
Timothy C. Jensen - Chapel Hill NC, US

International Classification:

G01N 33/50
B01L 3/00

Abstract:

A basket for use with a fluidics device for simulating in vivo membrane permeation and response is provided. The basket includes an impermeable surface defining a bottom aperture for positioning within the host fluid of the dosing well of the fluidics device. Further, the basket further includes a permeable membrane positioned within the basket and covering the bottom aperture. Additionally, the basket includes a layer covering at least a portion of the membrane covering the bottom aperture for exposing a bottom side of the layer to the host fluid and for preventing an opposing top side of the layer from being exposed to the host fluid. A dose may be placed in contact with the layer for analyzing downstream permeations and responses.