- New York NY, US Carol Prives - New York NY, US Timothy Osborne - Merritt Island FL, US
Assignee:
THE TRUSTEES OF COLUMBIA UNIVERSITY IN THE CITY OF NEW YORK - NEW YORK NY
International Classification:
A61K 31/4439 C12Q 1/68 A61K 45/06
US Classification:
514342, 5462704, 435 614, 435 611, 435 612
Abstract:
Fatostatin, a recently described inhibitor of SREBP activation, significantly reduces the level of mutant p53 binding to the HMG-CoA reductase gene promoter. Further, fatostatin treatment had a dramatic effect on normalizing the abnormal 3D morphology of 3 strains of breast cancer cells: MDA-468 cells, MDA-231 cells, and SKBR3 cells. The results show a functional interaction with SREBPs as being critical for mutant p53-mediated upregulation of the mevalonate pathway genes. At a clinical level, inhibition of the mevalonate pathway, either alone or in combination with other therapies, offers a novel, safe and much needed therapeutic option for tumors bearing mutant p53.
News
Researchers discover mouse species with elephant genes
Suspecting they may have encountered a new species, the teamincluding research colleagues in Namibia, Timothy Osborne (California Academy of Sciences), Michael Griffin (Republic of Namibia Ministry of Environment and Tourism), and Seth Eiseb (National Museum of Namibia), all co-authors on the paper
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