Timothy Barry Robbins

US Patent:

56727062, Sep 30, 1997

Filed:

Apr 17, 1996

Appl. No.:

8/633605

Inventors:

Anthony R. Haight - Mundelein IL
Owen J. Goodmonson - Buffalo Grove IL
Shyamal I. Parekh - Gurnee IL
Timothy A. Robbins - Waukegan IL
Lou S. Seif - Buffalo Grove IL

Assignee:

Abbott Laboratories - Abbott Park IL

International Classification:

C07D20944
C07D22114
C07C21300
C07C20968

US Classification:

546 99

Abstract:

A process is disclosed for the preparation of the substantially pure compound of the formula: ##STR1## comprising catalytic hydrogenation of a compound of the formula: ##STR2## wherein R. sub. 6 and R. sub. 7 are independently selected from ##STR3## wherein R. sub. a and R. sub. b are independently selected from hydrogen, loweralkyl and phenyl and R. sub. c, R. sub. d and R. sub. e are independently selected from hydrogen, loweralkyl, trifluoromethyl, alkoxy, halo and phenyl; and ##STR4## wherein the naphthyl ring is unsubstituted or substituted with one, two or three substitutents independently selected from loweralkyl, trifluoromethyl, alkoxy and halo; or R. sub. 6 and R. sub. 7 taken together with the nitrogen atom to which they are bonded are ##STR5## wherein R. sub. f, R. sub. g, R. sub. h and R. sub. i are independently selected from hydrogen, loweralkyl, alkoxy, halogen and trifluoromethyl; or an acid addition salt thereof.