Timothy Michael Vaughan

US Patent:

59831316, Nov 9, 1999

Filed:

Aug 9, 1996

Appl. No.:

8/695032

Inventors:

James C. Weaver - Sudbury MA
Uwe Pliquett - Bielefeld-Grossdornberg, DE
Timothy Vaughan - Chestnut Hill MA

Assignee:

Massachusetts Institute of Technology - Cambridge MA

International Classification:

A61N 130

US Classification:

604 20

Abstract:

The present invention relates to an apparatus and method for localized electroporation of tissue. An apparatus includes a perforate electrically insulating layer, a first electrode at a first side of the perforate electrically insulating layer and a second electrode at a second side of the perforate electrically insulating layer. An electric field extending between the first and second electrodes will preferentially extend through perforations of the electrically insulating layer. The electric field thereby causes electroporation of tissue that is proximate to the first electrode and is partitioned from the electrically insulating layer and the second electrode by the first electrode. The apparatus controllably limits the depth of the electric field within a tissue, such as skin, thereby electroporating a surface layer, such as a stratum corneum layer of the skin, without stimulating submerged nerve endings within the skin. Sensation of the applied voltage and especially pain sensation can thereby be controlled by the invention.