Michael A. Walker - Durham CT, US Chen Li - Storrs CT, US John D. Matiskella - Wallingford CT, US B. Narasimhulu Naidu - Durham CT, US Jacques Banville - St-Hubert, CA Francis Beaulieu - Laprairie, CA Carl Ouellet - Boucherville, CA Annapurna Pendri - Glastonbury CT, US Roger Remillard - Napierville, CA Yasutsugu Ueda - Clinton CT, US Ting T. Yin - Hamden CT, US
The invention encompasses a series bicyclic pyrimidinone compounds of Formula I which inhibit HIV integrase and prevent viral integration into human DNA. This action makes the compounds useful for treating HIV infection and AIDS. The invention also encompasses pharmaceutical compositions and methods for treating those infected with HIV.