Ting Yong Zhang

US Patent:

20190233406, Aug 1, 2019

Filed:

Jan 11, 2019

Appl. No.:

16/246068

Inventors:

- Rahway NJ, US
James Mulhearn - Elkins Park PA, US
Junying Zheng - New Providence NJ, US
Ronald M. Kim - Summit NJ, US
Ting Zhang - Princeton Junction NJ, US
Anthony J. Roecker - Harleysville PA, US
Walter Won - Alpine NJ, US
Philippe Nantermet - Lansdale PA, US
Rajan Anand - Fanwood NJ, US
Gang Zhou - Bridgewater NJ, US
Deping Wang - Furlong PA, US
Liangqin Guo - Edison NJ, US

Assignee:

Merck Sharp & Dohme Corp. - Rahway NJ

International Classification:

C07D 417/12
A61K 31/426
A61K 31/433
A61K 31/427
A61K 31/551
C07D 277/52
C07D 285/08
A61K 45/06

Abstract:

Disclosed are compounds of Formula A, or a salt thereof:wherein R, R, and E are defined herein, which compounds have properties for inhibiting Na1.7 ion channels found in peripheral and sympathetic neurons. Also described are pharmaceutical formulations comprising the compounds of Formula A or their salts, and methods of treating pain disorders, cough, and itch using the same.

US Patent:

20190092738, Mar 28, 2019

Filed:

Mar 17, 2017

Appl. No.:

16/086654

Inventors:

- Kenilworth NJ, US
Mark E. Layton - Harleysville PA, US
Thomas J. Greshock - Collegeville PA, US
Joseph E. Pero - Harleysville PA, US
Ting Zhang - Princeton Junction NJ, US

Assignee:

Merck Sharp & Dohme Corp. - Kenilworth NJ

International Classification:

C07D 277/52
C07D 285/08
A61K 31/635
A61K 45/06

Abstract:

Disclosed are compounds of Formula A-1, or a salt thereof: Formula A-1, where J, K, Q and R1 are as defined herein, which compounds have properties for inhibiting sodium ion channels found in peripheral and sympathetic neurons. Also described are pharmaceutical formulations comprising the compounds of Formula A-1 or their salts, and methods of treating pain (e.g. chronic pain), or cough or itch disorders using the same.

US Patent:

20180030036, Feb 1, 2018

Filed:

Dec 7, 2015

Appl. No.:

15/534029

Inventors:

Ting ZHANG - Rahway NJ, US
Yi-Heng CHEN - Rahway NJ, US
Liangqin GUO - Rahway NJ, US
Alan HARUZA - Rahway NJ, US
Tianying JIAN - Rahway NJ, US
Bing LI - Rahway NJ, US
Dongfang MENG - Rahway NJ, US
Edward C. SHERER - Rahway NJ, US
Harold B. WOOD - Rahway NJ, US
Isao SAKURADA - Tokyo, JP
- Rahway NJ, US
- Tokyo, JP

Assignee:

MERCK SHARP & DOHME CORP. - Rahway NJ
MOCHIDA PHARMACEUTICAL CO., LTD - Tokyo

International Classification:

C07D 403/12
C07D 401/14
C07D 401/12
C07D 471/04

Abstract:

The present invention provides a compound of Formula I, and pharmaceutical compositions comprising one or more said compounds, and methods for using said compounds for treating or preventing unstable angina, refractory angina, myocardial infarction, transient ischemic attacks, atrial fibrillation, thrombotic stroke, embolic stroke, deep vein thrombosis, disseminated intravascular coagulation, ocular build up of fibrin, and reocclusion or restenosis of recanalized vessels. The compounds are selective Factor IXa inhibitors.

US Patent:

20180022747, Jan 25, 2018

Filed:

Feb 12, 2016

Appl. No.:

15/550862

Inventors:

Dongfang MENG - Rahway NJ, US
Hong LI - Rahway NJ, US
Meng YANG - Rahway NJ, US
Manuel de Lera RUIZ - West Point PA, US
Sunita V. DEWNANI - Secaucus NJ, US
Tianying JIAN - Rahway NJ, US
Ting ZHANG - Rahway NJ, US
Louis-Charles CAMPEAU - Rahway NJ, US
Bart HARPER - Rahway NJ, US
Harold B. WOOD - Rahway NJ, US
Jiayi XU - Rahway NJ, US
Richard BERGER - West Point PA, US
Jane Yang WU - Rahway NJ, US
Robert K. ORR - Rahway NJ, US
Shawn P. WALSH - Kenilworth NJ, US
- Rahway NJ, US

Assignee:

Merck Sharp & Dohme Corp. - Rahway NJ

International Classification:

C07D 471/04
C07D 403/12
C07D 498/04
C07D 417/14
C07D 513/04
C07D 471/14
C07D 413/14

Abstract:

The present invention provides a compound of Formula I and pharmaceutical compositions comprising one or more said compounds, and methods for using said compounds for treating or preventing unstable angina, refractory angina, myocardial infarction, transient ischemic attacks, atrial fibrillation, thrombotic stroke, embolic stroke, deep vein thrombosis, disseminated intravascular coagulation, ocular build up of fibrin, and reocclusion or restenosis of recanalized vessels. The compounds are selective Factor IXa inhibitors.

US Patent:

20170174674, Jun 22, 2017

Filed:

Dec 14, 2016

Appl. No.:

15/378465

Inventors:

- Rahway NJ, US
James Mulhearn - Elkins Park PA, US
Junying Zheng - New Providence NJ, US
Ronald M. Kim - Summit NJ, US
Ting Zhang - Princeton Junction NJ, US
Anthony J. Roecker - Harleysville PA, US
Walter Won - Alpine NJ, US
Philippe Nantermet - Lansdale PA, US
Rajan Anand - Fanwood NJ, US
Gang Zhou - Bridgewater NJ, US
Deping Wang - Furlong PA, US
Liangqin Guo - Edison NJ, US

Assignee:

Merck Sharp & Dohme Corp. - Rahway NJ

International Classification:

C07D 417/12
C07D 277/52
A61K 31/551
A61K 31/427
A61K 31/433
A61K 31/426
C07D 285/08
A61K 45/06

Abstract:

Disclosed are compounds of Formula A, or a salt thereof:wherein R, R, and E are defined herein, which compounds have properties for inhibiting Na1.7 ion channels found in peripheral and sympathetic neurons. Also described are pharmaceutical formulations comprising the compounds of Formula A or their salts, and methods of treating pain disorders, cough, and itch using the same.

US Patent:

20170129880, May 11, 2017

Filed:

Apr 10, 2015

Appl. No.:

15/303310

Inventors:

Isao Sakurada - Tokyo, JP
Tomokazu Hirabayashi - Tokyo, JP
Yoshitaka Maeda - Tokyo, JP
Hiroshi Nagasue - Tokyo, JP
Takashi Mizuno - Tokyo, JP
Jiayi Xu - Marlboro NJ, US
Ting Zhang - Princeton Junction NJ, US
Cameron Smith - Montgomery Village MD, US
Dann Parker - Cranford NJ, US

International Classification:

C07D 413/14
A61K 45/06
C07D 417/14
A61K 31/428
C07D 471/04
A61K 31/52
A61K 31/506
A61K 31/4439
C07D 519/00
A61K 31/497
A61K 31/501
A61K 31/423
A61K 31/437

Abstract:

In its many embodiments, the present invention provides a novel class of benzamide compounds represented by Formula (I) or pharmaceutically acceptable salts or solvates thereof, or pharmaceutical compositions comprising one or more said compounds or pharmaceutically acceptable salts or solvates thereof, and methods for using said compounds or pharmaceutically acceptable salts or solvates thereof for treating or preventing a thromboses, embolisms, hypercoagulability or fibrotic changes.

US Patent:

20170027916, Feb 2, 2017

Filed:

Apr 10, 2015

Appl. No.:

15/303322

Inventors:

- Rahway NJ, US
- Tokyo, JP
Yoshitaka Maeda - Gotemba City, JP
Hiroshi Nagasue - Gotemba City, JP
Takashi Mizuno - Gotemba City, JP
Jiayi Xu - Marlboro NJ, US
Ting Zhang - Princeton Junction NJ, US
Cameron Smith - Montgomery Village MD, US
Dann Parker - Cranford NJ, US

Assignee:

Merck Sharp & Dohme Corp. - Rahway NJ
Mochida Pharmaceutical Co., Ltd. - Tokyo

International Classification:

A61K 31/439
A61K 45/06
A61K 31/444
A61K 31/506
A61K 31/501
C07D 519/00
C07D 413/14
C07D 498/04

Abstract:

In its many embodiments, the present invention provides a novel class of benzamide compounds represented by Formula (I) or pharmaceutically acceptable salts or solvates thereof, or pharmaceutical compositions comprising one or more said compounds or pharmaceutically acceptable salts or solvates thereof, and methods for using said compounds or pharmaceutically acceptable salts or solvates thereof for treating or preventing a thromboses, embolisms, hypercoagulability or fibrotic changes.

US Patent:

20150329562, Nov 19, 2015

Filed:

Dec 16, 2013

Appl. No.:

14/652174

Inventors:

- Rahway NJ, US
John Qiang Tan - Westfield NJ, US
Ting Zhang - Princeton Junction NJ, US
James Balkovec - Martinsville NJ, US
William John Greenlee - Teaneck NJ, US
Liangqin Guo - Edison NJ, US
Yi-Heng Chen - Whippany NJ, US
Yili Chen - Hillsborough NJ, US
Samuel Chackalamannil - Califon NJ, US
Tomokazu Hirabayashi - Shizuoka Prefecture, JP
Mika Sekioka - Shizuoka Prefecture, JP

Assignee:

Merck Sharp & Dohme Corp. - Rahway NJ
Mochida Pharmaceutical Co., Ltd. - Tokyo

International Classification:

C07D 513/04
C07D 413/14

Abstract:

The present invention provides a compound of Formula (I)wherein