Todd A Guion

US Patent:

55715680, Nov 5, 1996

Filed:

Jun 7, 1995

Appl. No.:

8/474114

Inventors:

Hans O. Ribi - San Mateo CA
Todd Guion - Palo Alto CA
Paul T. Shafer - Burlingame CA

Assignee:

Biocircuits Corporation - Sunnyvale CA

International Classification:

B05D 302
B05D 306

US Classification:

427487

Abstract:

Bioelectronic sensors are provided employing a thin surfactant polymeric electrically conducting layer to which may be bound members of specific binding pairs. Binding of an analyte or a reagent to the specific binding pair member layer may change the electrical, optical, or structural properties of the layer for measurement of analyte. The change in the polymeric layer provides for a sensitive measurement.

US Patent:

58514880, Dec 22, 1998

Filed:

Feb 29, 1996

Appl. No.:

8/608693

Inventors:

Tom Saul - El Granada CA
Henry L. Schwartz - Menlo Park CA
Todd Guion - Felton CA
Hans O. Ribi - Hillsborough CA

Assignee:

Biocircuits Corporation - Sunnyvale CA

International Classification:

G01N 2164

US Classification:

422 67

Abstract:

An electro-optical instrument for measuring a quantitative physical parameter of a sample in a diagnostic cartridge is provided.

US Patent:

54279151, Jun 27, 1995

Filed:

Aug 9, 1993

Appl. No.:

8/104429

Inventors:

Hans O. Ribi - San Mateo CA
Todd A. Guion - Burlingame CA
Joseph R. Murdoch - Burlingame CA
John C. Scott - Los Gatos CA
Victor Pan - Burlingame CA
Glenda L. Choate - Belmont CA

Assignee:

Biocircuits Corporation - Sunnyvale CA

International Classification:

G01N 3353

US Classification:

435 792

Abstract:

Apparatus and methods are provided for the detection of analytes. A polyunsaturated polymerized lipid layer is employed, which is anisotropic, has a member of a specific binding pair bound to an end of the lipids, and whose optical characteristics are modified upon complex formation between the specific binding pair member and its complementary member. By providing for polarized light, linear and/or circular, one can detect the presence of complex formation by the change in the optical characteristics of the film. Polarizers, analyzers, and wave plates are employed for providing for a light signal which can be analyzed and related to the presence of an analyte in a sample.

US Patent:

54910978, Feb 13, 1996

Filed:

Feb 28, 1994

Appl. No.:

8/203846

Inventors:

Hans O. Ribi - Hillsborough CA
Todd Guion - San Mateo CA
Paul T. Shafer - Campbell CA

Assignee:

Biocircuits Corporation - Sunnyvale CA

International Classification:

G01N 3353

US Classification:

436518

Abstract:

Methods are provided for the detection of an analyte in a sample using a bioelectronic sensor comprising a thin surfactant polymeric electrically conducting layer to which members of specific binding pairs are bound. Specific binding of analyte or analyte competitor to the bound specific binding pair member results in a change in the conductivity of the polymer. The resultant change in conductivity is related to the presence of analyte in the sample.

US Patent:

52683052, Dec 7, 1993

Filed:

Dec 13, 1990

Appl. No.:

7/627027

Inventors:

Hans O. Ribi - San Mateo CA
Todd A. Guion - Burlingame CA
Joseph R. Murdoch - Burlingame CA
John C. Scott - Los Gatos CA
Victor Pan - Burlingame CA
Glenda L. Choate - Belmont CA

Assignee:

Biocircuits Corporation - Sunnyvale CA

International Classification:

G01N 3353
G01N 2101

US Classification:

436501

Abstract:

Apparatus and methods are provided for the detection of analytes. A polyunsaturated polymerized lipid layer is employed, which is anisotropic, has a member of a specific binding pair bound to an end of the lipids, and whose optical characteristics are modified upon complex formation between the specific binding pair member and its complementary member. By providing for polarized light, linear and/or circular, one can detect the presence of complex formation by the change in the optical characteristics of the film. Polarizers, analyzers, and wave plates are employed for providing for a light signal which can be analyzed and related to the presence of an analyte in a sample.