Todd D Palcic

US Patent:

20080053908, Mar 6, 2008

Filed:

Sep 4, 2007

Appl. No.:

11/899059

Inventors:

Lalit Chordia - Pittsburgh PA, US
Harbaksh Sidhu - Cranberry Township PA, US
Todd Palcic - Pittsburgh PA, US
John Whelan - Pittsburgh PA, US

International Classification:

B01D 15/08

US Classification:

210656, 2101982, 210 85

Abstract:

A method for separating a sample using high pressure flash chromatography is provided. The method comprises the steps of: i) providing a pressurized vessel containing an adsorption material; ii) pressurizing a compressible fluid, optionally containing a cosolvent, to create a mobile phase; iii) premixing the sample with the mobile phase or optionally placing the sample in the pressurized vessel; iv) eluting the mobile phase through the pressurized vessel, to obtain a separated sample; v) heating the mobile phase containing the separated sample after the mobile phase exits the pressurized vessel to remove the compressible fluid; and iv) collecting the separated sample. The pressurized vessel contains an adsorption material having a particle size of 10-100 microns, and the pressure of the adsorption vessel is held at 50-350 bar during elution. Also provided is an apparatus for carrying out the above method.

US Patent:

20110180481, Jul 28, 2011

Filed:

Jan 26, 2011

Appl. No.:

13/014204

Inventors:

Lalit Chordia - Pittsburgh PA, US
Harbaksh Sidhu - Allison Park PA, US
Todd Palcic - Pittsburgh PA, US
John Whelan - Mt. Lebanon PA, US

Assignee:

THAR INSTRUMENTS, INC. - Pittsburgh PA

International Classification:

B01D 15/08

US Classification:

210656

Abstract:

A method for separating a sample using high pressure flash chromatography is provided. The method comprises the steps of: i) providing a pressurized vessel containing an adsorption material; ii) pressurizing a compressible fluid, optionally containing a cosolvent, to create a mobile phase; iii) premixing the sample with the mobile phase or optionally placing the sample in the pressurized vessel; iv) eluting the mobile phase through the pressurized vessel, to obtain a separated sample; v) heating the mobile phase containing the separated sample after the mobile phase exits the pressurized vessel to remove the compressible fluid; and iv) collecting the separated sample. The pressurized vessel contains an adsorption material having a particle size of 10-100 microns, and the pressure of the adsorption vessel is held at 50-350 bar during elution. Also provided is an apparatus for carrying out the above method.