Tom C Yuan

US Patent:

20230002478, Jan 5, 2023

Filed:

Jun 22, 2022

Appl. No.:

17/847104

Inventors:

- South San Francisco CA, US
Qiang LIU - Palo Alto CA, US
Tom YUAN - San Francisco CA, US

International Classification:

C07K 16/10
A61P 31/14

Abstract:

Provided herein are methods and compositions relating to libraries of optimized antibodies having nucleic acids encoding for an antibody comprising modified sequences. Libraries described herein comprise nucleic acids encoding SARS-CoV-2 or ACE2 antibodies. Further described herein are protein libraries generated when the nucleic acid libraries are translated. Further described herein are cell libraries expressing variegated nucleic acid libraries described herein.

US Patent:

20210395344, Dec 23, 2021

Filed:

Apr 27, 2021

Appl. No.:

17/242179

Inventors:

- South San Francisco CA, US
Qiang LIU - Palo Alto CA, US
Tom YUAN - San Francisco CA, US

International Classification:

C07K 16/10
C07K 16/00

Abstract:

Provided herein are methods and compositions relating to libraries of optimized antibodies having nucleic acids encoding for an antibody comprising modified sequences. Libraries described herein comprise nucleic acids encoding SARS-CoV-2 or ACE2 antibodies. Further described herein are protein libraries generated when the nucleic acid libraries are translated. Further described herein are cell libraries expressing variegated nucleic acid libraries described herein.

US Patent:

20210380678, Dec 9, 2021

Filed:

Jul 9, 2019

Appl. No.:

17/257820

Inventors:

- South San Francisco CA, US
Yang LI - Mountain View CA, US
Wen-Chen YEH - Belmont CA, US
Tom Zhiye YUAN - Union City CA, US
Helene BARIBAULT - Redwood City CA, US

International Classification:

C07K 16/28
C07K 14/47
A61P 1/16

Abstract:

The present disclosure provides tissue-specific Wnt signal enhancing molecules, and related methods of using these molecules to increase Wnt signaling in liver tissues.

US Patent:

20210355194, Nov 18, 2021

Filed:

Apr 27, 2021

Appl. No.:

17/242170

Inventors:

- South San Francisco CA, US
Qiang LIU - Palo Alto CA, US
Tom YUAN - San Francisco CA, US

International Classification:

C07K 16/10

Abstract:

Provided herein are methods and compositions relating to libraries of optimized antibodies having nucleic acids encoding for an antibody comprising modified sequences. Libraries described herein comprise nucleic acids encoding SARS-CoV-2 or ACE2 antibodies. Further described herein are protein libraries generated when the nucleic acid libraries are translated. Further described herein are cell libraries expressing variegated nucleic acid libraries described herein.

US Patent:

20210102195, Apr 8, 2021

Filed:

Sep 23, 2020

Appl. No.:

17/030232

Inventors:

- South San Francisco CA, US
Pankaj GARG - Burlingame CA, US
Qiang LIU - Palo Alto CA, US
Tom YUAN - South San Francisco CA, US

International Classification:

C12N 15/10
C07K 16/28

Abstract:

Provided herein are methods and compositions relating to variant nucleic acid libraries encoding for antibodies including single domain antibodies. Libraries generated using methods described herein have improved characteristics including improved binding affinity. Libraries described herein include variegated libraries comprising nucleic acids each encoding for a predetermined variant of at least one predetermined reference nucleic acid sequence. Further described herein are protein libraries generated when the nucleic acid libraries are translated. Further described herein are cell libraries expressing variegated nucleic acid libraries described herein.

US Patent:

20210079089, Mar 18, 2021

Filed:

Dec 19, 2018

Appl. No.:

16/954483

Inventors:

- South San Francisco CA, US
Tom Zhiye YUAN - Union City CA, US
Aaron Ken SATO - Burlingame CA, US
Wen-Chen YEH - Belmont CA, US
Parthasarathy SAMPATHKUMAR - South San Francisco CA, US

International Classification:

C07K 16/28

Abstract:

The present invention provides anti-LRP5/6 monoclonal antibodies and related compositions, which may be used in any of a variety of therapeutic methods for treating diseases and disorders associated with Wnt pathway signaling.

US Patent:

20200308287, Oct 1, 2020

Filed:

Dec 19, 2018

Appl. No.:

16/954484

Inventors:

- South San Francisco CA, US
Tom Zhiye YUAN - Union City CA, US
Aaron Ken SATO - Burlingame CA, US
Wen-Chen YEH - Belmont CA, US
Claudia Yvonne JANDA - Palo Alto CA, US
Tristan William FOWLER - San Francisco CA, US
Helene BARIBAULT - Redwood City CA, US
Liqin XIE - South San Francisco CA, US
Randall J. BREZSKI - South San Francisco CA, US
Chenggang LU - South San Francisco CA, US

International Classification:

C07K 16/28
C07K 16/46

Abstract:

The present invention provides Wnt pathway agonists and related compositions, which may be used in any of a variety of therapeutic methods for the treatment of diseases.

US Patent:

20160355545, Dec 8, 2016

Filed:

Sep 3, 2014

Appl. No.:

14/913951

Inventors:

- Oakland CA, US
- Bedford Park, South Australia, AU
Tom Z. Yuan - Los Angeles CA, US
Callum Ormonde - Nedlands WA, US
Stephan Timothy Kudlacek - Irvine CA, US

Assignee:

THE REGENTS OF THE UNIVERSITY OF CALIFORNIA - Oakland CA
FLINDERS UNIVERSITY - Bedford Park, South Australia

International Classification:

C07K 1/113
C12N 9/36
C07K 1/14
C07K 14/47
C07K 14/005

Abstract:

A method of improving protein functionality includes obtaining a protein such as protein contained within exclusion bodies contained within bacteria or yeast used for the recombinant expression of the protein. The exclusion bodies are solubilized using a chaotropic agent such as guanidine or urea. The protein is then subject to denaturation conditions and optionally purified. A liquid containing the denatured protein is loaded into a vessel that is angled relative to horizontal. The vessel is then rotated in the angled configuration at a rate within that is less than 10,000 RPM for period of time. Refolded protein is formed by the high shear conditions formed in the thin film of fluid formed in the inner surface of the rotating vessel. Refolding can be performed in a batch mode or a continuous mode. The process may be scaled up for industrial applications by using multiple vessels.