Tony J Fleming

US Patent:

6423501, Jul 23, 2002

Filed:

Oct 20, 1997

Appl. No.:

08/954279

Inventors:

Tony Fleming - Newton MA
Jean-Pierre Kinet - Lexington MA

Assignee:

Beth Israel Deaconess Medical Center - Boston MA

International Classification:

G01N 3353

US Classification:

435 721, 435 71, 435 72, 435 78, 435 691, 435 724, 435174, 435 5, 530300, 530350, 530351, 4241431

Abstract:

Calcium independent CD81 inhibition of IgE-mediated degranulation in mast cells, particularly through the FcRIII and FC RI receptors, is described, as well as methods of inhibiting allergic processes.

US Patent:

7026283, Apr 11, 2006

Filed:

Dec 5, 2001

Appl. No.:

10/004562

Inventors:

Tony Fleming - Stow MA, US
Jean-Pierre Kinet - Lexington MA, US

Assignee:

Beth Israel Deaconess Medical Center, Inc. - Boston MA

International Classification:

A61K 39/395
A61K 39/00
C12N 15/00

US Classification:

514 2, 4241391, 435 71, 530300, 530350, 5303879, 5303881

Abstract:

Calcium independent CD81 inhibition of IgE-mediated degranulation in mast cells, particularly through the FcγRIII and FcεRI receptors, is described, as well as methods of inhibiting allergic processes.

US Patent:

7118872, Oct 10, 2006

Filed:

Aug 17, 2001

Appl. No.:

09/932322

Inventors:

James P. Beltzer - Carlisle MA, US
Marilou Potter, legal representative - Acton MA, US
Tony J. Fleming - Waltham MA, US
Robert Charles Ladner - Ijamsville MD, US

Assignee:

Dyax Corp. - Cambridge MA

International Classification:

G01N 33/53
A61K 38/00

US Classification:

435 71, 514 12, 514 13, 514 15

Abstract:

Binding polypeptides comprising specific amino acid sequences are disclosed that bind B Lymphocyte Stimulator (BLyS) protein or BLyS-like polypeptides. The binding polypeptides can be used in methods of the invention for detecting or isolating BLyS protein or BLyS-like polypeptides in solutions or mixtures, such as blood, tissue samples, or conditioned media.

US Patent:

8062906, Nov 22, 2011

Filed:

Feb 5, 2010

Appl. No.:

12/701301

Inventors:

James P. Beltzer - Carlisle MA, US
M. Daniel Potter - Acton MA, US
Tony J. Fleming - Waltham MA, US

Assignee:

Human Genome Sciences, Inc. - Rockville MD

International Classification:

G01N 33/566
A61K 38/00

US Classification:

436501, 530326

Abstract:

Binding polypeptides that specifically bind B lymphocyte stimulator protein or B lymphocyte stimulator-like polypeptides can be used in methods of the invention for detecting, diagnosing, or prognosing a disease or disorder associated with aberrant B lymphocyte stimulator or B lymphocyte stimulator receptor expression or inappropriate function of B lymphocyte stimulator or B lymphocyte stimulator receptor, comprising B lymphocyte stimulator binding polypeptides or fragments or variants thereof, that specifically bind to B lymphocyte stimulator. The present invention further relates to methods and compositions for preventing, treating or ameliorating a disease or disorder associated with aberrant B lymphocyte stimulator or B lymphocyte stimulator receptor expression or inappropriate B lymphocyte stimulator function or B lymphocyte stimulator receptor function, comprising administering to an animal, preferably a human, an effective amount of one or more B lymphocyte stimulator binding polypeptides or fragments or variants thereof, that specifically bind to B lymphocyte stimulator.

US Patent:

20030091565, May 15, 2003

Filed:

Aug 17, 2001

Appl. No.:

09/932613

Inventors:

James Beltzer - Carlisle MA, US
M. Potter - , US
Marilou Potter - Acton MA, US
Tony Fleming - Waltham MA, US
Craig Rosen - Laytonsville MD, US

International Classification:

A61K039/395

US Classification:

424/144100

Abstract:

Binding polypeptides that specifically bind BLyS protein or BLyS-like polypeptides can be used in methods of the invention for detecting, diagnosing, or prognosing a disease or disorder associated with aberrant BLyS or BLyS receptor expression or inappropriate function of BLyS or BLyS receptor, comprising BLyS binding polypeptides or fragments or variants thereof, that specifically bind to BLyS. The present invention further relates to methods and compositions for preventing, treating or ameliorating a disease or disorder associated with aberrant BLyS or BLyS receptor expression or inappropriate BLyS function or BLyS receptor function, comprising administering to an animal, preferably a human, an effective amount of one or more BLyS binding polypeptides or fragments or variants thereof, that specifically bind to BLyS.

US Patent:

20060084608, Apr 20, 2006

Filed:

Sep 20, 2005

Appl. No.:

11/232439

Inventors:

James Beltzer - Carlisle MA, US
M. Potter - Acton MA, US
Tony Fleming - Waltham MA, US
Craig Rosen - Laytonsville MD, US
Marilou Potter - Acton MA, US

International Classification:

A61K 38/10

US Classification:

514014000

Abstract:

Binding polypeptides that specifically bind BLyS protein or BLyS-like polypeptides can be used in methods of the invention for detecting, diagnosing, or prognosing a disease or disorder associated with aberrant BLyS or BLyS receptor expression or inappropriate function of BLyS or BLyS receptor, comprising BLyS binding polypeptides or fragments or variants thereof, that specifically bind to BLyS. The present invention further relates to methods and compositions for preventing, treating or ameliorating a disease or disorder associated with aberrant BLyS or BLyS receptor expression or inappropriate BLyS function or BLyS receptor function, comprising administering to an animal, preferably a human, an effective amount of one or more BLyS binding polypeptides or fragments or variants thereof, that specifically bind to BLyS.

US Patent:

20100233177, Sep 16, 2010

Filed:

Apr 11, 2008

Appl. No.:

12/595538

Inventors:

David Langdon Yowe - Cambridge MA, US
Dmitri Mikhailov - Cambridge MA, US
Tony Fleming - Cambridge MA, US

International Classification:

A61K 39/395
C07K 16/40
C12N 5/02
A61P 9/00

US Classification:

4241391, 5303879, 5303873, 435375, 530327, 530326, 530329

Abstract:

Epitopes of Proprotein convertase subtilisin/kexin type 9 (PCSK9), compositions that bind to PCSK9 and PCSK9 epitopes, and methods of using the compositions are described herein.

US Patent:

20120022006, Jan 26, 2012

Filed:

Sep 22, 2011

Appl. No.:

13/239604

Inventors:

James P. Beltzer - Carlisle MA, US
M. Daniel Potter - Acton MA, US
Marilou Potter - Acton MA, US
Tony J. Fleming - Waltham MA, US
Craig A. Rosen - Laytonsville MD, US

Assignee:

HUMAN GENOME SCIENCES, INC. - Rockville MD

International Classification:

A61K 38/10
C07K 7/08
A61P 37/00
C07K 16/00
C07K 1/14
G01N 33/566
C07K 14/00

US Classification:

514 214, 436501, 530326, 530350, 5303873, 530413

Abstract:

Binding polypeptides that specifically bind B lymphocyte stimulator protein or B lymphocyte stimulator-like polypeptides can be used in methods of the invention for detecting, diagnosing, or prognosing a disease or disorder associated with aberrant B lymphocyte stimulator or B lymphocyte stimulator receptor expression or inappropriate function of B lymphocyte stimulator or B lymphocyte stimulator receptor, comprising B lymphocyte stimulator binding polypeptides or fragments or variants thereof, that specifically bind to B lymphocyte stimulator. The present invention further relates to methods and compositions for preventing, treating or ameliorating a disease or disorder associated with aberrant B lymphocyte stimulator or B lymphocyte stimulator receptor expression or inappropriate B lymphocyte stimulator function or B lymphocyte stimulator receptor function, comprising administering to an animal, preferably a human, an effective amount of one or more B lymphocyte stimulator binding polypeptides or fragments or variants thereof, that specifically bind to B lymphocyte stimulator.