Tracy J Hamilton

US Patent:

53824687, Jan 17, 1995

Filed:

Dec 22, 1992

Appl. No.:

7/995070

Inventors:

Mark S. Chagnon - Pelham NH
John R. Ferris - Newburyport MA
Barry L. Fiore - Auburn AL
Michelle J. Carter - Derry NH
Tracy J. Hamilton - Hudson NH

Assignee:

Molecular Bioquest, Inc. - Atkinson NH

International Classification:

B32B 2702

US Classification:

428328

Abstract:

Subdomain metal or metal oxide particles covalently coupled to chemically reactive organic moieties and subsequently reacted together to form biodegradable magnetic microclusters are disclosed. The magnetic microcluster can be used as contrast agents in NMR imaging for the production of images suitable for use in diagnosis, for in vivo delivery and targeting of drugs, as in vivo, biodegradable agents for the sequestering of free metal ions in the treatment of metal driven disease.

US Patent:

52252825, Jul 6, 1993

Filed:

Dec 13, 1991

Appl. No.:

7/806478

Inventors:

Mark S. Chagnon - Pelham NH
John R. Ferris - Newburyport MA
Barry L. Fiore - Auburn AL
Michelle J. Carter - Derry NH
Tracy J. Hamilton - Hudson NH

Assignee:

Molecular BioQuest, Inc. - Atkinson NH

International Classification:

B32B 2700

US Classification:

428407

Abstract:

Subdomain metal or metal oxide particles covalently coupled to chemically reactive organic moieties and subsequently reacted together to form biodegradable magnetic microclusters are disclosed. The magnetic microcluster can be used as contrast agents in NMR imaging for the production of images suitable for use in diagnosis, for in vivo delivery and targeting of drugs, as in vivo, biodegradable agents for the sequestering of free metal ions in the treatment of metal driven disease.

US Patent:

53893778, Feb 14, 1995

Filed:

Oct 7, 1992

Appl. No.:

7/958646

Inventors:

Mark S. Chagnon - Pelham NH
John R. Ferris - Newburyport MA
Tracy J. Hamilton - Salem NH
Edwin A. Rudd - Salem NH
Michelle J. Carter - Derry NH

Assignee:

Molecular Bioquest, Inc. - Atkinson NH

International Classification:

A61K 9127

US Classification:

424450

Abstract:

A liposome composition which comprises a substantially uniform sized inorganic core coated with an amphipathic organic compound and further coated with a second amphipathic vesicle forming lipid. Also disclosed are novel phenyl lipid compounds which serve as the amphipathic vesicle forming lipid and methods are described for delivering a drug for slow release into the blood stream, and for targeting a selected tissue or cells with the inorganic core liposome compositions.

US Patent:

59358661, Aug 10, 1999

Filed:

Jun 8, 1992

Appl. No.:

7/894260

Inventors:

Mark S. Chagnon - Pelham NH
John R. Ferris - Newburyport MA
Michelle J. Carter - Derry NH
Tracy J. Hamilton - Hudson NH
Maria A. Gray - Derry NH

Assignee:

Binax NH, Inc. - Atkinson NH

International Classification:

G01N 33553
C12Q 168
C07F 728
C01G 4908

US Classification:

436526

Abstract:

Inorganic oxides of substantially uniform particle size distribution are prepared by contacting aqueous solutions of an inorganic salt and an inorganic base across a porous membrane wherein the membrane contains a plurality of pores which allows for precipitation of a substantially mono-disbursed size inorganic oxide particles on one side of the membrane and precipitation of a salt of the corresponding base on a second side of the membrane.

US Patent:

50710761, Dec 10, 1991

Filed:

Aug 10, 1990

Appl. No.:

7/565801

Inventors:

Mark S. Chagnon - Pelham NH
Tracy Hamilton - Lowell MA
John R. Ferris - Newburyport MA

Assignee:

Omni Quest Corporation - Atkinston NH

International Classification:

B02C 1912

US Classification:

241 21

Abstract:

A novel method for producing magnetic microparticles from metallocenes is disclosed. The method involves combining an aqueous slurry of the metallocene and an aqueous slurry of a metal hydroxide and milling the slurries together. Fine magnetic particles are produced using the present method.

US Patent:

55476821, Aug 20, 1996

Filed:

Jul 20, 1994

Appl. No.:

8/277655

Inventors:

Mark S. Chagnon - Pelham NH
Stephen E. Burkle - Andover MA
Michelle J. Carter - Derry NH
Tracy J. Hamilton - Plaistow NH
John Havelick - Wakefield MA
Deborah A. Kaplan - Derry NH
Kristin L. Marzloff - Auburn NH

Assignee:

BioQuest, Incorporated - Atkinson NH

International Classification:

A61K 916
A61K 950

US Classification:

424497

Abstract:

Novel N-RES agents for use in vitro and in vivo medical and biological applications, such as, for example MRI and/or intravenous administration of pharmaceutical agents are described. The novel N-RES agents are prepared by coating inorganic core particles with a poly(acrylic acid)--poly(alkylene ether) graft copolymer. The resulting polymer-coated inorganic particle cores are useful as imaging agents, therapeutic agents or carriers having increased circulation time due to decrease uptake or recognition by the RES.