Tracy M Handel

US Patent:

20070004906, Jan 4, 2007

Filed:

Apr 9, 2003

Appl. No.:

10/510658

Inventors:

Amanda Proudfoot - Chens Sur Leman, FR
Marie Kosco-Vilbois - Minzier, FR
Tracy Handel - Oakland CA, US

International Classification:

A61K 38/19
C07K 14/52

US Classification:

530351000, 424085100

Abstract:

Novel antagonists of MCP proteins, in particular of MCP-1 protein, can be obtained by generating MCP mutants whose GAG binding site, located at the N-terminal of MCP proteins, is eliminated following non-conservative substitutions. Compounds prepared in accordance with the present invention can be used in the treatment or prevention of diseases related to an undesirable activity of MCP proteins such, such as inflammatory disease, autoimmune diseases, vascular diseases, and cancer.