Trang T Le

US Patent:

20020049233, Apr 25, 2002

Filed:

Aug 17, 2001

Appl. No.:

09/932500

Inventors:

Tugrul Kararli - Skokie IL, US
Mark Kontny - Libertyville IL, US
Trang Le - Mundelein IL, US

International Classification:

A61K031/4439
A61K031/42
A61K031/415
A61K031/18
A61K031/34
B27N003/00

US Classification:

514/332000, 514/340000, 514/341000, 514/407000, 514/379000, 514/471000, 514/602000, 264/109000

Abstract:

A process is provided for preparing an oral fast-melt composition of a selective cyclooxygenase-2 inhibitory drug comprising (a) a step of wet granulating the selective cyclooxygenase-2 inhibitory drug together with a binding agent selected from gums, polypeptides, natural and modified starches, cellulosic materials, alginic acid and salts thereof, polyethylene glycol, polyvinylpyrrolidone, polymethacrylates, silicate salts and bentonites, and (b) a step of blending with the drug a saccharide of low moldability, wherein the above steps (a) and (b) occur in any order or simultaneously to result in formation of granules. Optionally the process further comprises (c) a step of blending the granules with at least one of a lubricant, a sweetening agent and a flavoring agent to form a tableting blend, and (d) a step of compressing the tableting blend to form oral fast-melt tablets. Also provided is a composition prepared by such a process.

US Patent:

20020071857, Jun 13, 2002

Filed:

Aug 17, 2001

Appl. No.:

09/932537

Inventors:

Tugrul Kararli - Skokie IL, US
Mark Kontny - Libertyville IL, US
Trang Le - Mundelein IL, US

International Classification:

A61K031/415
A61K031/353
A61K031/12

US Classification:

424/435000, 514/406000, 514/456000, 514/690000

Abstract:

A molded article such as a tablet is provided for administration to an oral cavity of a subject to treat or prevent a cyclooxygenase-2 mediated condition, disorder or disease. The molded article comprises a moldable blend of a therapeutically effective amount of a selective cyclooxygenase-2 inhibitory drug with a pharmaceutically acceptable excipient carrier system consisting predominantly of one or more carbohydrates, wherein ingredients and amounts thereof in the molded article and a process for preparing the molded article are selected such that the molded article exhibits rapid disintegration in the oral cavity, and wherein the moldable blend is prepared by a process step not requiring wet granulation.

US Patent:

20020119193, Aug 29, 2002

Filed:

Aug 17, 2001

Appl. No.:

09/932494

Inventors:

Trang Le - Mundelein IL, US
Tugrul Kararli - Skokie IL, US
Mark Kontny - Libertyville IL, US
Srikonda Sastry - Sunnyvale CA, US
Janaki Nyshadham - Fremont CA, US
Arthur Pagliero - Vacaville CA, US

International Classification:

A61K009/20
A61K031/435

US Classification:

424/465000, 514/406000, 514/378000, 514/277000, 514/473000

Abstract:

A process is provided for preparing an oral fast-melt composition of a selective cyclooxygenase-2 inhibitory drug, the process comprising (a) a step of wet granulating the drug together with a binding agent comprising a saccharide of high moldability, and (b) a step of blending with the drug a saccharide of low moldability, wherein the above steps (a) and (b) occur in any order or simultaneously to result in formation of granules. The process optionally incorporates means to inhibit agglomeration of the drug, for example addition of a wetting agent. Optionally the process further comprises (c) a step of blending the granules with at least one of a lubricant, a sweetening agent and a flavoring agent to form a tableting blend, and (d) a step of compressing the tableting blend to form oral fast-melt tablets. Also provided is a composition prepared by such a process.

US Patent:

20030181501, Sep 25, 2003

Filed:

Sep 23, 2002

Appl. No.:

10/252222

Inventors:

Trang Le - Vernon Hills IL, US
Blake Ludwig - Gurnee IL, US
Joseph Reo - Kalamazoo MI, US
Uday Shah - Hoffman Estates IL, US
Ken Yamamoto - Portage MI, US

International Classification:

A61K031/415
A61K009/20

US Classification:

514/406000, 424/465000

Abstract:

Orally disintegrating valdecoxib fast-melt tablets and processes for preparing such dosage forms are provided. The compositions are useful in treatment or prophylaxis of cyclooxygenase-2 mediated conditions and disorders