Usha R Patel

US Patent:

6506747, Jan 14, 2003

Filed:

Jun 3, 1999

Appl. No.:

09/324933

Inventors:

Rajashekhar Betageri - Bethel CT
Charles L. Cywin - Bethel CT
Karl Hargrave - Brookfield CT
Mary Ann Hoermann - Holmes NY
Thomas M. Kirrane - Danbury CT
Thomas M. Parks - San Mateo CA
Usha R. Patel - Brookfield CT
John R. Proudfoot - Newtown CT
Rajiv Sharma - Ridgefield CT
Sanxing Sun - Danbury CT
Xiao-Jun Wang - Danbury CT

Assignee:

Boehringer Ingelheim Pharmaceuticals, Inc. - Ridgefield CT

International Classification:

A61K 31535

US Classification:

5142288, 514307, 514300, 514340, 548235, 544353, 544 60, 544132

Abstract:

1-(4-aminophenyl)pyrazoles optionally substituted on the 3- and 5-positions of the pyrazole ring and on the amino group at the 4-position of the phenyl ring are disclosed and described, which pyrazoles inhibit IL-2 production in T-lymphocytes.

US Patent:

6506769, Jan 14, 2003

Filed:

Aug 2, 2001

Appl. No.:

09/921509

Inventors:

Roger John Snow - Danbury CT
Mario Cardozo - Brookfield CT
Daniel Goldberg - Redding CT
Abdelhakim Hammach - Danbury CT
Tina Morwick - New Milford CT
Neil Moss - Ridgefield CT
Usha R. Patel - Brookfield CT
Hidenori Takahashi - LaGrangeville NY
Matt Aaron Tschantz - Newtown CT
Xiao-Jun Wang - Danbury CT

Assignee:

Boehringer Ingelheim Pharmaceuticals, Inc. - Ridgefield CT

International Classification:

A61K 314745

US Classification:

514293, 514290, 514393, 514397, 546 82, 546141, 546148, 5462731

Abstract:

Disclosed are novel compounds of formula (I): wherein Ar , R , R , R , X and Y are defined below, which are useful as inhibitors of certain protein tyrosine kinases and are thus useful for treating diseases associated with such kinases, for example, diseases resulting from inappropriate cell proliferation, which include autoimmune diseases, chronic inflammatory diseases, allergic diseases, transplant rejection and cancer, as well as conditions resulting from cerebral ischemia, such as stroke. Also disclosed are processes for preparing these compounds, novel intermediates useful in these processes and compositions comprising compounds of the formula (I).

US Patent:

6525052, Feb 25, 2003

Filed:

Mar 14, 2001

Appl. No.:

09/808439

Inventors:

Younes Bekkali - Danbury CT
Eugene R. Hickey - Danbury CT
Weimin Liu - Shelton CT
Usha R. Patel - Brookfield CT
Denice M. Spero - West Redding CT
Sanxing Sun - Danbury CT
David S. Thomson - Ridgefield CT
Yancey D. Ward - Sandy Hook CT
Erick R. R. Young - Danbury CT

Assignee:

Boehringer Ingelheim Pharmaceuticals, Inc. - Ridgefield CT

International Classification:

A61K 31335

US Classification:

5142372, 514326, 544119, 544121, 544124, 544129, 546208

Abstract:

Disclosed are novel cathepsin S, K, F, L and B reversible inhibitory compounds of the formula (Ia) and (Ib) where R , R , R , R , R , R , R , Het and X are defined herein. The compounds are useful for treating autoimmune and other diseases. Also disclosed are processes for making such novel compounds.

US Patent:

6660732, Dec 9, 2003

Filed:

Sep 25, 2001

Appl. No.:

09/962709

Inventors:

Rajashehar Betageri - Bethel CT
Steffen Breitfelder - Danbury CT
Pier F. Cirillo - Woodbury CT
Thomas A. Gilmore - Middlebury CT
Eugene R. Hickey - Danbury CT
Thomas M. Kirrane - Danbury CT
Monica H. Moriak - Danbury CT
Neil Moss - Ridgefield CT
Usha R. Patel - Brookfield CT
John R. Proudfoot - Newtown CT
John R. Regan - Larchmont NY
Rajiv Sharma - Ridgefield CT
Sanxing Sun - Danbury CT
Alan D. Swinamer - Danbury CT
Hidenori Takahashi - LaGrangeville NY

Assignee:

Boehringer Ingelheim Pharmaceuticals, Inc. - Ridgefield CT

International Classification:

A61K 315377

US Classification:

5142278, 5142365, 5142368, 51425405, 51425505, 514318, 514333, 514341, 514371, 514377, 514398, 514404, 514406, 514426, 514447, 514472, 544 582, 544 586, 544122, 544131, 544140, 544371, 544405, 546193, 546256, 5462754, 548196, 548223, 5483315, 5483321, 5483641, 5483657, 5483717, 548557, 548558, 549 69, 549480

Abstract:

Disclosed are novel aromatic compounds which are useful for treating diseases or pathological conditions involving inflammation such as chronic inflammatory diseases. Also disclosed are pharmaceutical compositions containing and processes of making such compounds.

US Patent:

6770639, Aug 3, 2004

Filed:

Nov 12, 2002

Appl. No.:

10/292026

Inventors:

Roger John Snow - Danbury CT
Mario Cardozo - Brookfield CT
Daniel Goldberg - Redding CT
Abdelhakim Hammach - Danbury CT
Tina Morwick - New Milford CT
Neil Moss - Ridgefield CT
Usha R. Patel - Brookfield CT
Hidenori Takahashi - LaGrangeville NY
Matt Aaron Tschantz - Newtown CT
Xiao-Jun Wang - Danbury CT

Assignee:

Boehringer Ingelheim Pharmaceuticals, Inc. - Ridgefield CT

International Classification:

A61K 3133

US Classification:

514183, 514293, 514290, 514393, 514397, 546 82, 546141, 546148, 5462731

Abstract:

Disclosed are novel compounds of formula (I): wherein Ar , R , R , R , X and Y are defined below, which are useful as inhibitors of certain protein tyrosine kinases and are thus useful for treating diseases associated with such kinases, for example, diseases resulting from inappropriate cell proliferation, which include autoimmune diseases, chronic inflammatory diseases, allergic diseases, transplant rejection and cancer, as well as conditions resulting from cerebral ischemia, such as stroke. Also disclosed are processes for preparing these compounds, novel intermediates useful in these processes and compositions comprising compounds of the formula (I).

US Patent:

6787540, Sep 7, 2004

Filed:

Oct 1, 2002

Appl. No.:

10/261994

Inventors:

Younes Bekkali - Danbury CT
Eugene R. Hickey - Danbury CT
Weimin Liu - Shelton CT
Usha R. Patel - Brookfield CT
Denice M. Spero - West Redding CT
Sanxing Sun - Danbury CT
David S. Thomson - Ridgefield CT
Yancey D. Ward - Sandy Hook CT
Erick R. R. Young - Danbury CT

Assignee:

Boehringer Ingelheim Pharmaceuticals, Inc. - Ridgefield CT

International Classification:

A61K 31535

US Classification:

5142305, 544 92

Abstract:

Disclosed are novel cathepsin S, K, F, L and B reversible inhibitory compounds of the formula (Ia) and (Ib) where R , R , R , R , R , R , R , Het and X are defined herein. The compounds are useful for treating autoimmune and other diseases. Also disclosed are processes for making such novel compounds.

US Patent:

6858623, Feb 22, 2005

Filed:

May 29, 2003

Appl. No.:

10/448698

Inventors:

Younes Bekkali - Danbury CT, US
Eugene R. Hickey - Danbury CT, US
Weimin Liu - Sandy Hook CT, US
Usha R. Patel - Brookfield CT, US
Denice M. Spero - West Redding CT, US
Sanxing Sun - Danbury CT, US
David S. Thomson - Ridgefield CT, US
Yancey D. Ward - Sandy Hook CT, US
Erick R. R. Young - Danbury CT, US

Assignee:

Boehringer Ingelheim Pharmaceuticals, Inc. - Ridgefield CT

International Classification:

A61K031/445
A61K031/404
A61K031/428
A61K031/4468
A61K031/4523
A61K031/536
A61K031/55
C07D223/06
C07D265/28
C07D263/54
C07D277/62
C07D401/12
C07D451/02
C07D239/80

US Classification:

514304, 51421703, 5142292, 5142305, 5142312, 514259, 514317, 514358, 514373, 514418, 514426, 546125, 546207, 546208, 546209, 546215, 546347, 544 67, 544 90, 544111, 544253, 544359, 540524, 548207, 548486, 548566

Abstract:

Disclosed are novel cathepsin S, K, F, L and B reversible inhibitory compounds of the formula (Ia) and (Ib) where R, R, R, R, R, R, R, Het and X are defined herein. The compounds are useful for treating autoimmune and other diseases. Also disclosed are processes for making such novel compounds.

US Patent:

6936606, Aug 30, 2005

Filed:

Sep 27, 2002

Appl. No.:

10/256512

Inventors:

Younes Bekkali - Danbury CT, US
Denice Mary Spero - West Redding CT, US
Sanxing Sun - Danbury CT, US
David S. Thomson - Ridgefield CT, US
Yancey D. Ward - Sandy Hook CT, US
Erick R. R. Young - Danbury CT, US
Eugene R. Hickey - Danbury CT, US
Weimin Liu - Sandy Hook CT, US
Usha R. Patel - Brookfield CT, US

Assignee:

Boehringer Ingelheim Pharmaceuticals, Inc. - Ridgefield CT

International Classification:

C07D239/95
C07D265/24
C07D401/12
A61K031/517
A61K031/536

US Classification:

5142268, 5142298, 5142305, 5142663, 514267, 514373, 514416, 544 54, 544 89, 544 91, 544 92, 544250, 544286, 548212, 548472

Abstract:

Disclosed are novel cathepsin S, K, F, L and B reversible inhibitory compounds of the formulas (Ia) and (Ib) where R, R, R, R, R, R, R, Rand X are defined herein. The compounds are useful for treating autoimmune and other diseases. Also disclosed are processes for making such novel compounds.