Usha N Patel

US Patent:

49422340, Jul 17, 1990

Filed:

Feb 28, 1989

Appl. No.:

7/316888

Inventors:

Magid A. Abou-Gharbia - Wilmington DE
Guy A. Schiehser - Malvern PA
Usha R. Patel - Audubon PA

Assignee:

American Home Products Corporation - New York NY

International Classification:

C07D52100

US Classification:

544332

Abstract:

There are disclosed compounds of the formula ##STR1## wherein R. sup. 1 and R. sup. 2 are each, independently, hydrogen, lower alkyl, aryl or halo, or R. sup. 1 and R. sup. 2 taken together represent ##STR2## where the dotted lines represent optional double bonds; R. sup. 3, R. sup. 4 and R. sup. 5 are each, independently, hydrogen, lower alkyl, aryl or halo; R. sup. 6 is 2-pyridinyl, 2-pyrazinyl, 2-quinolyl, 2-quinoxalinyl or any of the foregoing R. sup. 6 moieties substituted by lower alkyl, lower alkoxy, trifluoromethyl, cyano, nitro or halo; or ##STR3## wherein R. sup. 7 is phenyl, 2-pyridinyl, 2-pyrimidinyl, 3-pyridazinyl or 2-pyrazinyl or any of the foregoing R. sup. 7 moieties substituted by lower alkyl, lower alkoxy, halo, cyano, trifluoromethyl or nitro; Z is ##STR4## X is lower alkylene, vinylene, O or NH; m is 1-5; n is 0-4; p is 1-4; q is 1-2; and the pharmaceutically acceptable salts thereof, and their use as antipsychotic/anxiolytic agents having a low liability for extrapyramidal side effects.

US Patent:

47662158, Aug 23, 1988

Filed:

Feb 27, 1987

Appl. No.:

7/019730

Inventors:

Magid A. Abou-Gharbia - Wilmington DE
Usha R. Patel - Audubon PA

Assignee:

American Home Products Corporation - New York NY

International Classification:

C07D40304
C07D40112
A61K 31495

US Classification:

544357

Abstract:

The compounds of the following formula are histamine H. sub. 1 -receptor antagonists: ##STR1## where R. sup. 3 and R. sup. 4 are, independently, hydrogen, halo, alkoxy of 1 to 3 carbon atoms or alkyl of 1 to 3 carbon atoms; R. sup. 2 is hydrogen or halo; n is one of the integers 0, 1 or 2; p is one of the integers 0 or 1; Y is --N. dbd. or --CH. dbd. , with the proviso that when Y is --N. dbd. , p is zero, and when Y is --CH. dbd. , p is one; and one of X. sub. 1 and X. sub. 2 is nitrogen and the other is --CH. dbd. ; or a pharmaceutically acceptable salt thereof.

US Patent:

49279343, May 22, 1990

Filed:

May 5, 1989

Appl. No.:

7/348332

Inventors:

Magid A. Abou-Gharbia - Wilmington DE
Usha R. Patel - Audubon PA

Assignee:

American Home Products Corporation - New York NY

International Classification:

C07D21506
C07D40106
C07D48708

US Classification:

546152

Abstract:

There are disclosed compounds of the formula ##STR1## wherein R represents ##STR2## where X is lower alkylene, vinylene or O; Y is lower alkylene or vinylene; the dotted line represents an optional double bond; m is 1-3; n is 2-4; A is phenyl, benzoyl, pyridinyl, quinolinyl or quinoxalinyl, or any of the foregoing substituted with lower alkyl, lower alkoxy, halo, cyano, nitro or trifluoromethyl; or when m is>1, A represents the grouping ##STR3## where B is phenyl, pyrimidinyl, pyridinyl or pyrazinyl, or any of the foregoing substituted with lower alkyl, lower alkoxy, halo, cyano, nitro or trifluoromethyl, with the proviso that were R is ##STR4## A is other than unsubstituted or substituted benzoyl or pyridinyl; and the pharmacologically acceptable salts thereof and their use as antipsychotic/anxiolytic and antidepressant agents and in the treatment of sexual dysfunction and having a low liability for extrapyramidal side effects.

US Patent:

46721177, Jun 9, 1987

Filed:

Sep 16, 1985

Appl. No.:

6/776349

Inventors:

Magid A. Abou-Gharbia - Brandywood DE
Usha R. Patel - King of Prussia PA
Reinhardt P. Stein - Audubon PA

Assignee:

American Home Products Corporation - New York NY

International Classification:

C07D40106
C07D47104
C07D24136

US Classification:

544405

Abstract:

The compounds: ##STR1## in which R. sup. 1 is hydrogen, halogen, hydroxy, or alkyl; R. sup. 2 is substituted or unsubstituted pyridinyl, pyrazinyl, quinolinyl or quinoxalinyl and said substituents are alkyl, alkoxy, alkoxycarbonyl, halogen, cyano or nitro; R. sup. 5 and R. sup. 6 are, independently, hydrogen, alkyl, phenyl, halophenyl, methylphenyl, trifluoromethylphenyl, cyanophenyl or nitrophenyl; with the proviso that one of R. sup. 5 and R. sup. 6 is other than hydrogen; and n is an integer from 1 to 7; or a pharmaceutically acceptable salt thereof, are antipsychotic and anxiolytic agents.

US Patent:

49373471, Jun 26, 1990

Filed:

May 5, 1989

Appl. No.:

7/348323

Inventors:

Magid A. Abou-Gharbia - Wilmington DE
Usha R. Patel - Audubon PA

Assignee:

American Home Products Corporation - New York NY

International Classification:

C07D40106
C07D40514

US Classification:

546272

Abstract:

These are disclosed compounds of the formula ##STR1## wherein R represents ##STR2## where X is lower alkylene, vinylene or O; Y is lower alkylene or vinylene; the dotted line represents an optional double bond; m is 1-3; n is 2-4; A is phenyl, benzoyl, pyridinyl, quinolinyl or quinoxalinyl, or any of the foregoing substituted with lower alkyl, lower alkoxy, halo, cyano, nitro or trifluoromethyl; or when m is >1, A represents the grouping ##STR3## where B is phenyl, pyrimidinyl, pyridinyl or pyrazinyl, or any of the foregoing substituted with lower alkyl, lower alkoxy, halo, cyano, nitro or trifluoromethyl, with the proviso that where R is ##STR4## A is other than unsubstituted or substituted benzoyl or pyridinyl; and the pharmacologically acceptable salts thereof and their use as antipsychotic/anxiolytic and antidepressant agents and in the treatment of sexual dysfunction and having a low liability for extrapyramidal side effects.

US Patent:

48332496, May 23, 1989

Filed:

Mar 5, 1987

Appl. No.:

7/022197

Inventors:

Magid A. Abou-Gharbia - Wilmington DE
Guy A. Schiehser - Malvern PA
Usha R. Patel - Audubon PA

Assignee:

American Home Products Corporation - New York NY

International Classification:

C07D41716
C07D52100

US Classification:

546270

Abstract:

There are disclosed compounds of the formula ##STR1## wherein R. sup. 1 and R. sup. 2 are each, independently, hydrogen, lower alkyl, aryl or halo, or R. sup. 1 and R. sup. 2 taken together represent ##STR2## where the dotted lines represent optional double bonds; R. sup. 3, R. sup. 4 and R. sup. 5 are each, independently, hydrogen, lower alkyl, aryl or halo; R. sup. 6 is 2-pyridinyl, 2-pyrazinyl, 2-quinolyl, 2-quinoxalinyl or any of the foregoing R. sup. 6 moieties substituted by lower alkyl, lower alkoxy, trifluoromethyl, cyano, nitro or halo; or R. sup. 6 is ##STR3## wherein R. sup. 7 is phenyl, 2-pyridinyl, 2-pyrimidinyl, 3-pyridazinyl or 2-pyrazinyl or any of the foregoing R. sup. 7 moieties substituted by lower alkyl, lower alkoxy, halo, cyano, trifluoromethyl or nitro; Z is --(CH. sub. 2). sub. n --, --O--, or ##STR4## X is lower alkylene, vinylene, O or NH; m is 1-5; n is 0-4; p is 1-4; q is 1-2; and the pharmaceutically acceptable salts thereof, and their use as antipsychotic/anxiolytic agents having a low liability for extrapyramidal side effects.

US Patent:

48554308, Aug 8, 1989

Filed:

Nov 12, 1987

Appl. No.:

7/119530

Inventors:

Magid A. Abou-Gharbia - Wilmington DE
Usha R. Patel - Audubon PA

Assignee:

American Home Products Corporation - New York NY

International Classification:

C07D40300
C07D40100

US Classification:

544373

Abstract:

There are disclosed compounds of the formula ##STR1## wherein R represents ##STR2## where X is lower alkylene, vinylene or O; Y is lower alkylene or vinylene; the dotted line represents an optional double bond; m is 1-3; n is 2-4; A is phenyl, benzoyl, pyridinyl, quinolinyl or quinoxalinyl, or any of the foregoing substituted with lower alkyl, lower alkoxy, halo, cyano, nitro or trifluoromethyl; or when m is>1, A represents the grouping ##STR3## where B is phenyl, pyrimidinyl, pyridinyl or pyrazinyl, or any of the foregoing substituted with lower alkyl, lower alkoxy, halo, cyano, nitro or trifluoromethyl, with the proviso that where R is ##STR4## A is other than unsubstituted or substituted benzoyl or pyridinyl; and the pharmacologically acceptable salts thereof and their use as antipsychotic/anxiolytic and antidepressant agents and in the treatment of sexual dysfunction and having a low liability for extrapyramidal side effects.