Val J Krukonis

US Patent:

7186796, Mar 6, 2007

Filed:

Feb 25, 2003

Appl. No.:

10/373542

Inventors:

Val Krukonis - Lexington MA, US
Kara T. Williams - Saugus MA, US
Anthony Gudinas - Atkinson NH, US
Hans Schonemann - Newburyport MA, US
Paula Wetmore - Chelmsford MA, US

Assignee:

Phasex Corporation - Lawrence MA

International Classification:

A61K 38/28
A61K 9/14
A61K 9/127
G01N 33/00

US Classification:

530303, 430350, 430399, 424 45, 424 46, 424450, 424491, 424499, 422 681, 422 81, 422101

Abstract:

Provided is a method of isolating a bio-molecule from a water-borne mixture, the method comprising: contacting the water-borne mixture with dimethyl ether to form solid particles of the bio-molecule.

US Patent:

7329789, Feb 12, 2008

Filed:

Oct 25, 2002

Appl. No.:

10/281335

Inventors:

Hans Schonemann - Newburyport MA, US
Anthony Gudinas - Atkinson NH, US
Kara Williams - Saugus MA, US
Paula Wetmore - Chelmsford MA, US
Val Krukonis - Lexington MA, US

Assignee:

Phasex Corporation - Lawrence MA

International Classification:

C07C 13/00
C07C 403/24
B01D 11/04

US Classification:

585351, 585 1, 585 20, 210634, 424425

Abstract:

Carotenoids are extracted and/or enriched from a mixture containing such compounds. The extraction/enrichment process involves the use of liquefied or supercritical solvents to extract lipids and carotenoids from carotenoid-containing substrates. The extraction process can also be performed in two steps in which lipids and carotenoids are first removed from a carotenoid-containing substrate with a liquefied or supercritical solvent, and subsequently a liquefied or supercritical gas is used to separate the lipids from the carotenoids. The two step process can be reversed to first extract lipids with the liquefied or supercritical gas, and subsequently use the solvent to extract the carotenoids. The process is also applicable to yield an organic solvent-free product from a carotenoid-containing source that was first extracted using an organic solvent.

US Patent:

7696396, Apr 13, 2010

Filed:

Jan 9, 2008

Appl. No.:

11/971532

Inventors:

Hans Schonemann - Newburyport MA, US
Anthony Gudinas - Atkinson NH, US
Kara Williams - Saugus MA, US
Paula Wetmore - Chelmsford MA, US
Val Krukonis - Lexington MA, US

Assignee:

Phasex Corporation - Lawrence MA

International Classification:

C07C 45/00
C07C 403/00
C07C 7/00

US Classification:

585351, 585360, 585803, 585833, 585866, 568366

Abstract:

Carotenoids are extracted and/or enriched from a mixture containing such compounds. The extraction/enrichment process involves the use of liquefied or supercritical solvents to extract lipids and carotenoids from carotenoid-containing substrates. The extraction process can also be performed in two steps in which lipids and carotenoids are first removed from a carotenoid-containing substrate with a liquefied or supercritical solvent, and subsequently a liquefied or supercritical gas is used to separate the lipids from the carotenoids. The two step process can be reversed to first extract lipids with the liquefied or supercritical gas, and subsequently use the solvent to extract the carotenoids. The process is also applicable to yield an organic solvent-free product from a carotenoid-containing source that was first extracted using an organic solvent.

US Patent:

7798151, Sep 21, 2010

Filed:

Jul 18, 2003

Appl. No.:

10/623006

Inventors:

Val Krukonis - Lexington MA, US
Hans Schonemann - Newburyport MA, US
Anthony Gudinas - Atkinson NH, US
Paula M. Wetmore - Chelmsford MA, US
Kara Williams - Saugus MA, US
Carl H. Midgett - Ashland City TN, US
Clifford Brown Bennett - Brentwood TN, US
Harry Y. Zheng - Smyrna TN, US
Kathleen S. Johnston - Nashville TN, US

Assignee:

US Smokeless Tobacco Co. - Greenwich CT
Phasex Corporation - Lawrence MA

International Classification:

A24B 3/18

US Classification:

131296, 131298

Abstract:

Methods of selectively reducing constituents in tobacco as well as the tobacco obtained by such methods are disclosed. Subcritical fluids, e. g. , liquid carbon dioxide, serve as the reduction media.

US Patent:

8071656, Dec 6, 2011

Filed:

Mar 3, 2009

Appl. No.:

12/397048

Inventors:

Brian J. Waibel - Kennett Square PA, US
Hans Schonemann - Newburyport MA, US
Val Krukonis - Lexington MA, US
David J. Lawrence - Newark DE, US
Joseph N. Caulfield - Aston PA, US

Assignee:

DynaSep LLC - Newark DE

International Classification:

C08J 11/04

US Classification:

521 498, 521 40, 521 49, 521 495, 528494, 528495, 528502 R, 528310, 528328, 528338, 528350, 528367, 523332, 523343

Abstract:

The present invention provides energetically and economically efficient methods for separating polyamide polymer(s) from commingled materials. The methods generally involve precipitating a polyamide polymer dissolved in a solvent (e. g. , formic acid) using dimethyl ether (DME) as an antisolvent. The methods comprise dissolving the polyamide polymer in a solvent that (i) selectively dissolves the polyamide polymer relative to the other materials and (ii) has a higher solubility for DME relative to the polyamide polymer; and then contacting the mixture of the solvent with the dissolved polyamide polymer with DME, thereby precipitating the polyamide polymer.

US Patent:

8263814, Sep 11, 2012

Filed:

May 15, 2008

Appl. No.:

12/300694

Inventors:

Brian J. J. Waibel - Kennett Square PA, US
Val J. Krukonis - Lexington MA, US

Assignee:

DynaSep Inc. - Wilmington DE

International Classification:

C07C 29/74
F25J 3/00

US Classification:

568913, 62617

Abstract:

The present invention provides methods and systems for extracting ethanol from an ethanol-water solution comprising (1) extracting ethanol from an ethanol-water solution with a first solvent comprising an esterified fatty acid, wherein the esterified fatty acid comprises a hydroxylated fatty acid component and an alcohol component such that the alcohol component is a Calcohol, such that the distribution coefficient for ethanol in the mixture of the ethanol-water solution and the first solvent is at least 0. 02 favoring the transfer of ethanol from the ethanol-water solution to the first solvent, thereby extracting the ethanol from the ethanol-water solution into the first solvent, and (2) extracting the ethanol-enriched first solvent with carbon dioxide, such that the carbon dioxide is at a liquid or near supercritical phase, wherein the distribution coefficient for ethanol in a mixture of the first solvent and the carbon dioxide is at least 0. 1 favoring the transfer of ethanol from the first solvent to the carbon dioxide.

US Patent:

8555895, Oct 15, 2013

Filed:

Sep 15, 2010

Appl. No.:

12/882783

Inventors:

Val Krukonis - Lexington MA, US
Hans Schonemann - Newburyport MA, US
Anthony Gudinas - Atkinson NH, US
Paula M. Wetmore - Chelmsford MA, US
Kara Williams - Saugus MA, US
Carl H. Midgett - Ashland City TN, US
Clifford Brown Bennett - Brentwood TN, US
Harry Y. Zheng - Smyrna TN, US
Kathleen S. Johnston - Nashville TN, US

Assignee:

U.S. Smokeless Tobacco Company LLC - Richmond VA
Phasex Corporation - Lawrence MA

International Classification:

A24B 15/24

US Classification:

131297, 131298, 131300

Abstract:

Methods of selectively reducing constituents in tobacco as well as the tobacco obtained by such methods are disclosed. Subcritical fluids, e. g. , liquid carbon dioxide, serve as the reduction media.

US Patent:

20050112215, May 26, 2005

Filed:

Oct 8, 2004

Appl. No.:

10/961421

Inventors:

Valerie Otto - New York NY, US
Dinesh Patel - Tuscon AZ, US
Val Krukonis - Lawrence MA, US

International Classification:

A61K035/78

US Classification:

424725000

Abstract:

In cramp bark preparations or tinctures currently available, there are no such preparations that have been standardized to a marker compound. In this type of standardization, one compound serves as a marker to indicate the presence of an identified active ingredient as well as the presence of other constituents that give the herb its therapeutic properties. The invention identifies a compound and a process by which to standardize preparations of cramp bark () and related species such as black haw, of the Genus of the Caprifoliaceae family (herein cramp bark). Verbenalin is an iridoid glycoside, and an alkaloid as well. The extraction process enriches or fortifies the yield of aglycon alkaloids and alkaloid glycosides in the botanical material of the Genus family, including cramp bark. Alkaloid glycosides include, without limitation, verbenalin, hastatoside, and verbacoside.