Valentina Z Petukhova

US Patent:

7094791, Aug 22, 2006

Filed:

Jul 31, 2003

Appl. No.:

10/631887

Inventors:

Wieslaw M. Cholody - Frederick MD, US
Valentina Petukhova - Rockville MD, US
Sean O'Brien - Gaithersburg MD, US
Norman Ohler - New Market MD, US
Stanislaw Pikul - Germantown MD, US

Assignee:

Avalon Pharmaceuticals, Inc. - Germantown MD

International Classification:

A61K 31/445
C07D 207/00

US Classification:

514326, 514343, 514423, 514422, 548530, 548518, 546208, 5462784

Abstract:

Chemical agents of the general formula (I) and (II), such as derivatives of 3-hydroxy-pyrrole containing hydroxamic acid, and including salts thereof, that modulate levels of gene expression in cellular systems, including cancer cells, are disclosed, along with methods for preparing such agents, as well as pharmaceutical compositions containing such agents as active ingredients and methods of using these as therapeutic agents.