Frederick R. Blattner - Madison WI Valerie Burland - Cross Plains WI Debra J. Rose - Fond du Lac WI George F. Mayhew - Madison WI Nicole Perna - Madison WI Robert D Perry - Lexington KY Susan C Straley - Lexington KY Jacqueline D. Fetherston - Lexington KY Luther E. Lindler - Wheaton MD Gregory V. Plano - Miami FL
Assignee:
Wisconsin Alumni Research Foundation - Madison WI
International Classification:
C12N 1563
US Classification:
4353201, 4352523, 536 231
Abstract:
The complete DNA sequence of three plasmids from the bacterium , the causative agent for bubonic plague, have been determined and are set forth. The open reading frames, or protein coding regions, of the plasmids have been determined. The DNA sequence and ORF information is useful for the creation of diagnostic, prophylactic and therapeutic tools for combating the disease caused by this agent.
Frederick R. Blattner - Madison WI, US Valerie Burland - Cross Plains WI, US Nicole T. Perna - Madison WI, US Guy Plunkett - Madison WI, US Rod Welch - Madison WI, US
Assignee:
Wisconsin Alumni Research Foundation - Madison WI
International Classification:
C12Q001/68 C07H021/02
US Classification:
536 231, 536 243, 435 6
Abstract:
The entire genome of pathogenic strain 0157:H7 has been sequenced. All of the genomic DNA sequences present in 0157 and absent in the previously sequenced laboratory strain K12 are presented here.
Frederick Blattner - Madison WI, US Rodney Welch - Madison WI, US Valerie Burland - Cross Plains WI, US
International Classification:
C12Q001/68 C07H021/04 C12N001/21
US Classification:
435/006000, 435/252330, 536/023700
Abstract:
The entire genome of pathogenic strain CFT073 has been sequenced. Nearly all of the genomic DNA sequences present in CFT073 and absent in the previously sequenced laboratory strain K-12 are presented here.
Compositions Comprising Reduced Genome Bacteria For Use In Treatment Of Sepsis
Methods for prophylaxis or treatment of sepsis in a subject are provided comprising administering to the subject a therapeutically effective dose of multiple deletion strain bacteria.
Frederick R. Blattner - Madison WI Valerie Burland - Cross Plains WI Nicole T. Perna - Madison WI Guy Plunkett - Madison WI Rod Welch - Madison WI
Assignee:
Wisconsin Alumni Research Foundation - Madison WI
International Classification:
C07H 2102
US Classification:
536 231, 536 243, 536 2431, 536 2432, 536 2433
Abstract:
The entire genome of pathogenic strain O157:H7 has been sequenced. All of the genomic DNA sequences present in O157 and absent in the previously sequenced laboratory strain K12 are presented here.