Valerie H Odegard

US Patent:

20110217302, Sep 8, 2011

Filed:

Oct 9, 2009

Appl. No.:

13/123509

Inventors:

Valerie Odegard - Seattle WA, US
Catherine J. McMahan - Seattle WA, US
Peter Robert Baum - Seattle WA, US
Peter Armstrong Thompson - Bellevue WA, US
Philip Tan - Edmonds WA, US
John W. Blankenship - Seattle WA, US
Sateesh Kumar Natarajan - Redmond WA, US

Assignee:

Emergent Product Development Seattle, LLC - Seattle WA

International Classification:

A61K 39/395
C12N 15/63
G01N 33/566
C07K 19/00
C07H 21/00
C07K 16/46
A61P 37/06
A61P 11/06
A61P 3/10
A61P 19/02

US Classification:

4241341, 4353201, 435 724, 5303873, 536 234

Abstract:

Single chain fusion proteins that specifically bind to a TCR complex or a component thereof, such as TCRα, TCRβ, or CD3ε, along with compositions and methods of use thereof are provided.

US Patent:

20220249685, Aug 11, 2022

Filed:

Jun 18, 2020

Appl. No.:

17/618857

Inventors:

- Seattle WA, US
Peter Robert BAUM - Seattle WA, US
Robert DUBOSE - Seattle WA, US
Valerie ODEGARD - Seattle WA, US

International Classification:

A61K 47/68
A61P 35/00
C07K 16/28
C07K 16/30

Abstract:

Anti-mesothelin antibodies and conjugates comprising such antibodies are disclosed herein as well as the use of such conjugates in the treatment of disease, such as cancer.

US Patent:

20230062712, Mar 2, 2023

Filed:

Dec 9, 2021

Appl. No.:

17/547034

Inventors:

- Seattle WA, US
Robert Dubose - Seattle WA, US
Valerie Odegard - Seattle WA, US
Philip Tan - Seattle WA, US
Peter A. Thompson - Seattle WA, US
Sean W. Smith - Seattle WA, US
Brenda Stevens - Seattle WA, US

International Classification:

A61K 47/68
A61P 31/20
A61K 31/55
A61K 45/06
C07K 16/28
A61K 47/65

Abstract:

The disclosure provides conjugates of anti-ASGR1 antibodies or antigen binding fragments thereof to a myeloid cell agonist, compositions comprising the conjugates, and methods of treating liver viral infections with the conjugates. The disclosure also provides for anti-ASGR1 antibodies or antigen binding fragments thereof and methods for using the antibodies or antigen binding fragments thereof in treating liver viral infections.

US Patent:

20210275683, Sep 9, 2021

Filed:

Feb 19, 2021

Appl. No.:

17/180110

Inventors:

- Seattle WA, US
Robert Dubose - Seattle WA, US
Valerie Odegard - Seattle WA, US
Brenda Stevens - Seattle WA, US
Philip Tan - Seattle WA, US

International Classification:

A61K 47/68
C07K 16/28
A61K 31/55
A61K 47/65
A61P 35/00

Abstract:

The present disclosure provides conjugates of anti-Nectin-4 antibodies or antigen binding fragments thereof to a myeloid cell agonist, compositions comprising the conjugates, and methods of treating cancer with the conjugates. The present disclosure also provides for anti-Nectin-4 antibodies or antigen binding fragments thereof and method for using the antibodies or antigen binding fragments thereof in treating cancer.

US Patent:

20210154317, May 27, 2021

Filed:

Jun 24, 2020

Appl. No.:

16/911358

Inventors:

- Seattle WA, US
Valerie Odegard - Seattle WA, US
Robert Finley Dubose - Seattle WA, US
Sean Wesley Smith - Seattle WA, US
Craig Alan Coburn - Seattle WA, US

International Classification:

A61K 47/68
C07K 16/28
A61P 1/16
A61P 31/20
A61P 31/14
C07D 401/12
C07D 223/16
C07D 403/12
C07D 401/14
C07F 5/02
C07D 471/04

Abstract:

Various compositions are disclosed for the treatment of viral infections. The compositions of conjugates comprise antibody constructs attached to myeloid cell agonists via a linker are also provided. Additionally provided are the methods of preparation and use of the conjugates. This includes methods for treating viral infections, such as viral liver diseases.

US Patent:

20210130473, May 6, 2021

Filed:

Oct 9, 2020

Appl. No.:

17/066897

Inventors:

- Seattle WA, US
Robert DUBOSE - Seattle WA, US
Valerie ODEGARD - Seattle WA, US
Philip TAN - Seattle WA, US
Peter A. THOMPSON - Seattle WA, US
Sean W. SMITH - Seattle WA, US
Brenda STEVENS - Seattle WA, US

International Classification:

C07K 16/28
A61K 31/444
A61K 31/4709
A61K 47/68

Abstract:

Various conjugates and compositions thereof are disclosed for use in the treatment of a liver disease, such as liver cancer and liver fibrosis. The compositions comprise conjugates, wherein the conjugates are comprised of an antibody or antibody construct specific for ASGR1 or ASGR2 attached to a TGFβR1 inhibitor via a linker. Additionally provided are the methods of preparation of the conjugates and compositions thereof.

US Patent:

20210115109, Apr 22, 2021

Filed:

Apr 23, 2020

Appl. No.:

16/856689

Inventors:

- Seattle WA, US
Robert Finley Dubose - Seattle WA, US
Peter Robert Baum - Seattle WA, US
Valerie Odegard - Seattle WA, US

International Classification:

C07K 14/735
C07K 16/00

Abstract:

Various compositions are disclosed. The compositions of conjugates comprising immune-modulatory agents are also provided. Additionally provided are the methods of preparation and use of the conjugates. This includes methods for treating disorders, such as cancer and fibrosis.

US Patent:

20200199247, Jun 25, 2020

Filed:

Jun 7, 2018

Appl. No.:

16/620429

Inventors:

- Seattle WA, US
Badreddin EDRIS - Seattle WA, US
Craig Alan COBURN - Seattle WA, US
Peter Robert BAUM - Seattle WA, US
Valerie ODEGARD - Seattle WA, US

International Classification:

C07K 16/32
C07K 16/28
C07K 16/30
A61K 47/68
A61P 35/00

Abstract:

Antibody conjugates of immune-modulatory compounds and pharmaceutical compositions for use in the treatment of disease, such as fibrotic diseases, autoimmune, or autoinflammatory diseases, are disclosed herein. The disclosed conjugates are useful, among other things, in treating fibrotic diseases, autoimmune diseases, or autoinflammatory diseases, such as by modulating TGFβR1, TGFβR2, TNKS, TNIK, or mTOR.