John C. Reed - Rancho Santa Fe CA, US Frederick F. Pio - Vancouver, CA Adam Godzik - San Diego CA, US Christian Stehlik - San Diego CA, US Jason S. Damiano - La Jolla CA, US Sug Hyung Lee - San Diego CA, US Vasco A. Oliveira - San Diego CA, US Hideki Hayashi - Nagasaki, JP Kryzysztof Pawlowski - Malmo, SE
Assignee:
Burnham Institute for Medical Research - La Jolla CA
International Classification:
C07K 14/00
US Classification:
530350
Abstract:
The invention provides caspase recruitment domain (CARD)-containing polypeptides, CARD, NB-ARC, ANGIO-R, LRR and SAM domains therefrom, as well as encoding nucleic acid molecules and specific antibodies. The invention also provides related screening, diagnostic and therapeutic methods.
Card Domain Containing Polypeptides, Encoding Nucleic Acids, And Methods Of Use
John Reed - Rancho Santa Fe CA, US Frederick Pio - Vancouver, CA Adam Godzik - San Diego CA, US Christian Stehlik - San Diego CA, US Jason Damiano - La Jolla CA, US Sug Lee - San Diego CA, US Vasco Oliveira - San Diego CA, US Hideki Hayashi - Nagasaki City, JP Krzysztof Pawlowski - Malmo, SE
The invention provides caspase recruitment domain (CARD)-containing polypeptides, CARD, NB-ARC, ANGIO-R, LRR and SAM domains therefrom, as well as encoding nucleic acid molecules and specific antibodies. The invention also provides related screening, diagnostic and therapeutic methods.
Card3X-2 Polypeptides, Encoding Nucleic Acids, And Methods Of Use
John Reed - Rancho Santa Fe CA, US Frederick Pio - British Columbia, CA Adam Godzik - San Diego CA, US Christian Stehlik - Morgantown WV, US Jason Damiano - San Diego CA, US Sug Lee - Seoul, KR Vasco Oliveira - San Diego CA, US Hideki Hayashi - Nagasaki City, JP Kryzysztof Pawlowski - Malmo, SE
The invention provides a polypeptide corresponding to a newly identified splice variant of the CARD3X gene, termed CARD3X-2. Also provided by the invention is an encoding nucleic acid molecule, as well as a CARD3X-2 specific antibody. The invention further provides related screening, diagnostic and therapeutic methods.