Vernon Earl Walker

US Patent:

20130040291, Feb 14, 2013

Filed:

Oct 12, 2012

Appl. No.:

13/651371

Inventors:

Dale M. WALKER - Jericho VT, US
Vernon E. WALKER - Jericho VT, US

International Classification:

C12Q 1/18
C12Q 1/68
C12Q 1/02

US Classification:

435 61, 435 32, 435 29

Abstract:

The assessment methods disclosed herein involve exposing cells to two stresses. The first stress (analogous to existing direct screening methods) involves exposing metazoan cells to an external stimulus of interest, such as exposing human cells to ionizing radiation, a chemical, or a set of physical conditions. The cells exposed to the first stress are thereafter exposed to a second stress which, importantly, is calibrated such that non-stressed cells of the same type will exhibit a predictable response to the second stress. By comparing the response to the second stress of i) cells that were exposed to the first stress and ii) cells that were not exposed to the first stress, an observer can assess whether exposure to the first stress caused or induced any change to the cells that affected the cells' ability to respond to the second stress.

US Patent:

20130337046, Dec 19, 2013

Filed:

Jun 14, 2013

Appl. No.:

13/917931

Inventors:

Dale M. WALKER - Jericho VT, US
Vernon E. WALKER - Jericho VT, US

International Classification:

A61K 31/145
A61K 31/661

US Classification:

424450, 514114, 514665

Abstract:

The disclosure relates to methods of improving safety, efficacy, or both, of pharmaceutically active aminothiol compounds by delivering them in a thiol-protected form and, preferably intracellularly.

US Patent:

20110053894, Mar 3, 2011

Filed:

Apr 17, 2007

Appl. No.:

11/736471

Inventors:

Dale M. Walker - Albuquerque NM, US
Adriana Elisa Kajon - Albuquerque NM, US
Vernon E. Walker - Albuquerque NM, US

Assignee:

LOVELACE RESPIRATORY RESEARCH INSTITUTE - Albuquerque NM

International Classification:

A61K 31/661
A61K 31/13
A61P 31/12
A61P 31/20
A61P 31/14
A61K 31/66

US Classification:

514114, 514665

Abstract:

A method for the prevention or treatment of Influenza virus infection or Adenovirus infection by administering an effective amount of a compound of Formula (I), Formula (II), or similar compound to an individual in need is provided.

US Patent:

20220273802, Sep 1, 2022

Filed:

Jan 13, 2022

Appl. No.:

17/574885

Inventors:

- Jericho VT, US
Vernon E. WALKER - Jericho VT, US

International Classification:

A61K 47/54
A61K 31/145
A61K 31/661
A61K 9/00

Abstract:

The disclosure relates to methods of improving safety, efficacy, or both, of pharmaceutically active aminothiol compounds by delivering them in a thiol-protected form and, preferably intracellularly.

US Patent:

20210023229, Jan 28, 2021

Filed:

Aug 7, 2020

Appl. No.:

16/988239

Inventors:

- Jericho VT, US
Vernon E. WALKER - Jericho VT, US
Tsvetelina I. LAZAROVA - Brookline MA, US
Steven W. RIESINGER - Boston MA, US

International Classification:

A61K 47/60
A61K 31/145
A61P 31/14
A61P 35/02
A61P 35/00

Abstract:

In one aspect, the present application relates to an aminothiol-conjugate of formula (I):wherein , , R, R, R, m, n, and p are as described above. The present invention also relates to a method of treating a subject in need of aminothiol therapy using an aminothiol-conjugate of formula (I).

US Patent:

20200093841, Mar 26, 2020

Filed:

Apr 30, 2019

Appl. No.:

16/399186

Inventors:

- Jericho VT, US
Adriana Elisa Kajon - Albuquerque NM, US
Vernon E. Walker - Jericho VT, US

International Classification:

A61K 31/661
A61K 31/66
A61K 31/13
A61K 45/06

Abstract:

A method for the prevention or treatment of Influenza virus infection or Adenovirus infection by administering an effective amount of a compound of Formula (I), Formula (II), or similar compound to an individual in need is provided.

US Patent:

20190083630, Mar 21, 2019

Filed:

Nov 16, 2018

Appl. No.:

16/193168

Inventors:

- Jericho VT, US
Vernon E. WALKER - Jericho VT, US

International Classification:

A61K 47/54
A61K 9/00
A61K 31/661
A61K 31/145

Abstract:

The disclosure relates to methods of improving safety, efficacy, or both, of pharmaceutically active aminothiol compounds by delivering them in a thiol-protected form and, preferably intracellularly.

US Patent:

20180369398, Dec 27, 2018

Filed:

Nov 17, 2016

Appl. No.:

15/776674

Inventors:

- Jericho VT, US
Vernon E. WALKER - Jericho VT, US
Tsvetelina I. LAZAROVA - Brookline MA, US
Steven W. RIESINGER - Boston MA, US

International Classification:

A61K 47/60
A61P 35/00
A61P 35/02
A61P 31/14
A61K 31/145

Abstract:

In one aspect, the present application relates to an aminothiol-conjugate of formula (I), wherein Core Linker R, R, R, m, n, and p are as described above. The present invention also relates to a method of treating a subject in need of aminothiol therapy using an aminothiol-conjugate of formula (I).