The present disclosure relates to CTLA4 proteins and uses of such proteins, for example to treat diseases associated with the dysregulation of immune responses.
The present disclosure relates to CTLA4 proteins and uses of such proteins, for example to treat diseases associated with the dysregulation of immune responses.
Anti-Pd-1/Lag3/Tigit Trispecific Antibodies And Anti-Pd-1/Lag3 Bicpecific Antibodies
Veronica JUAN - South San Francisco CA, US Robert A. KASTELEIN - Porta Valley CA, US - Rahway NJ, US
Assignee:
Merck Sharp & Dohme Corp. - Rahway NJ
International Classification:
C07K 16/28 A61K 45/06 A61P 35/00
Abstract:
Provided herein are treatments of conditions ameliorated by counteracting tumor mediated immune suppression. More specifically, provided herein are anti-PD-1/LAG-3/TIGIT trispecific antibodies, anti-PD-1/LAG3 bispecific antibodies, anti-LAG3 antibodies and antigen-binding fragments. Also provided here are methods and uses of these antibodies and antigen-binding fragments in the treatment of cancer or infectious disease.
Veronica Juan - Palo Alto CA, US Shireen Khan - Castro Valley CA, US Shaopeng Huang - Shanghai, CN Hua Ying - Shanghai, CN - Rahway NJ, US
Assignee:
Merck Sharp & Dohme Corp. - Rahway NJ
International Classification:
C07K 16/28 A61K 39/395 A61K 45/06
Abstract:
The present invention relates to anti-PD-1 antibodies and antigen-binding fragments, and use of these antibodies and antigen-binding fragments in the treatment of cancer or infectious disease.
- Rahway NJ, US Wolfgang Seghezzi - Mountain View CA, US Linda Liang - Mountain View CA, US Veronica Juan - Redwood City CA, US
Assignee:
Merck Sharp & Dohme Corp. - Rahway NJ
International Classification:
C07K 16/28 A61P 31/00 A61K 39/395
Abstract:
The present invention relates to anti-TIGIT antibodies, as well as use of these antibodies in the treatment of diseases such as cancer and infectious disease.
Novel Anti-B7H3 Binding Compounds And Uses Thereof
- Belmont CA, US Veronica Juan - Redwood City CA, US
International Classification:
C07K 16/28
Abstract:
The invention is directed to novel antibody binding compounds specific for the human B7H3 and uses of such compounds for diagnostic and therapeutic purposes.
- Rahway NJ, US - Haarlem, NL Veronica Juan - Redwood City CA, US Svetlana Sadekova - Mountain View CA, US Jerelyn Wong - San Jose CA, US Hans van Eenennaam - Nijmegen, NL Andrea van Elsas - Oss, NL Lars Guelen - Nijmegen, NL Thierry Olivier Fischmann - Scotch Plains NJ, US Winifred W. Prosise - Ramsey NJ, US
- Rahway NJ, US Wolfgang Seghezzi - Mountain View CA, US Linda Liang - Mountain View CA, US Veronica Juan - Redwood City CA, US
Assignee:
Merck Sharp & Dohme Corp. - Rahway NJ
International Classification:
C07K 16/28 A61K 39/395 A61P 31/00
Abstract:
The present invention relates to anti-TIGIT antibodies, as well as use of these antibodies in the treatment of diseases such as cancer and infectious disease.
Veronica Juan (1996-2000), Valeria Lopez (1991-1995), Irvin Tejas (2000-2004), Juan Macias (1983-1987), Ray Jones (1960-1963), Larissa Payan (1989-1992)