Nigel Jenkins - Lausanne, GB Derrick Witcher - Fishers IN, US Victor Wroblewski - Carmel IN, US
International Classification:
A61K038/17
US Classification:
514/008000
Abstract:
The present invention provides FLINT isoforms having an average sialic acid content of 0.5, 1.0, 1.5, 2.0, 2.5, 3.0, 3.5, 4.0 or greater than 4.0 per molecule of FLINT. Also provided are mixtures of said isoforms, and methods for making said isoforms.
Gerald Wayne Becker - Fishers IN, US Fredric Jay Cohen - Newtown PA, US John Edward Hale - Fishers IN, US Radmila Micanovic - Indianapolis IN, US Christy Michelle Newton - Indianapolis IN, US Timothy Wayne Noblitt - Fishers IN, US Radhakrishnan Rathnachalam - Carmel IN, US Sheng-Hung Rainbow Tschang - Carmel IN, US Derrick Ryan Witcher - Fishers IN, US Victor John Wroblewski - Carmel IN, US
Assignee:
Eli Lilly and Company - Indianapolis IN
International Classification:
C07K014/705 C07H021/04
US Classification:
530350, 536 235
Abstract:
Disclosed are polypeptide analogs of FLINT, polydeoxynucleotides encoding FLINT analogs, and methods of using FLINT analogs and polydeoxynucleotides. The FLINT analogs of the invention include polypeptides having the amino acid sequence of FLINT, modified at one or more positions with amino acid substitutions, and include fragments thereof, as well as Fc fusions comprising FLINT and FLINT analogs.
Resumes
Research Fellow At Eli Lilly And Company Research Fellow At Eli Lilly And Company
Eli Lilly and Company (Public Company; 10,001 or more employees; LLY; Pharmaceuticals industry): Research Fellow, (-) Eli Lilly and Company (Public Company; 10,001 or more employees; LLY; Pharmaceuticals industry): Research Fellow, (-)