Vipul R Shah

US Patent:

6926823, Aug 9, 2005

Filed:

Sep 23, 2002

Appl. No.:

10/252276

Inventors:

Krishna M. R. Kallury - Torrance CA, US
David C. Jones - Long Beach CA, US
Vipul J. Shah - West Covina CA, US

Assignee:

Varian, Inc. - Palo Alto CA

International Classification:

B01J019/00
B01J020/26

US Classification:

2101982, 2105021, 210635, 210656, 210659, 210634, 536 231, 536 254, 502402

Abstract:

A polymeric sorbent that can be employed in the extraction and purification of polar and nonpolar molecules from a complex media (e. g. pharmaceuticals from biological matrices) by solid phase extraction (SPE). The sorbent exhibits a strong capacity for the retention of polar molecules and can facilitate the recovery of compounds possessing a range of polarities while furnishing clean extracts showing low ion suppression. The polymer is wettable and remains wetted over long periods of time.

US Patent:

7056858, Jun 6, 2006

Filed:

Jun 16, 2005

Appl. No.:

11/154214

Inventors:

Krishna M. R. Kallury - Torrance CA, US
David C. Jones - Long Beach CA, US
Vipul J. Shah - West Covina CA, US

Assignee:

Varian, Inc. - Palo Alto CA

International Classification:

B01J 20/26

US Classification:

502402

Abstract:

A polymeric sorbent that can be employed in the extraction and purification of polar and nonpolar molecules from a complex media (e. g. pharmaceuticals from biological matrices) by solid phase extraction (SPE). The sorbent exhibits a strong capacity for the retention of polar molecules and can facilitate the recovery of compounds possessing a range of polarities while furnishing clean extracts showing low ion suppression. The polymer is wettable and remains wetted over long periods of time.

US Patent:

7125945, Oct 24, 2006

Filed:

Sep 19, 2003

Appl. No.:

10/664617

Inventors:

Vipul J. Shah - West Covina CA, US

Assignee:

Varian, Inc. - Palo Alto CA

International Classification:

C08F 12/08
B01D 15/08

US Classification:

526346, 526242, 526296, 210635, 210634, 210679, 435803

Abstract:

Halogenated polymers of vinyl aromatic monomers comprising styrene and divinylbenzene are provided for use in a chromatographic separation method of analytes, wherein said polymer further comprises a hydrocarbyl or halocarbyl substituent comprising from 1 to 1,000,000 carbon atoms, or combinations thereof. Methods of using the halogenated polymers are also provided. The polymers and methods are particularly useful in the separation of nucleic acids labeled with hydrophobic labels such as protecting groups, fluorophores, and the like.

US Patent:

7311825, Dec 25, 2007

Filed:

May 2, 2005

Appl. No.:

11/120003

Inventors:

Vipul J. Shah - West Covina CA, US

Assignee:

Varian, Inc. - Palo Alto CA

International Classification:

B01D 15/08

US Classification:

2101982, 2105021, 210635, 210656

Abstract:

A polymer modified porous substrate for solid phase extraction or chromatography, comprising a porous substrate and a polymeric monolith formed thereon, wherein the polymeric monolith comprises Cmonocyclic or bicyclic aryl or heteroaryl, optionally substituted with -L-Q-R; where q is 0-3, p is 0-5, Q is —NRC(O)—, —C(O)NR—, —OC(O)NR—, —OC(O)R—, —NRC(O)O—, —NRC(O)NR—, —NCO, —CHOHCHOH—, CHOCHCHO—, —(CHCHO)—, —(CHCHCHO)—, —C(O)—, —C(O)O—, —CHC(O)CH—, —S—, —SS—, —CHOH—, —O—, —SO—, —SO—, —SO—, —OSO, —SONR—, —NR—, and —NR—, —CN, —NC, —CHOCH—, —NHC(NH)NH—, —NO, —NO, —OPO—, —OH; and R is hydrogen, Cmonocyclic or bicyclic aryl or heteroaryl, Cbranched, unbranched, or cyclic hydrocarbyl; L is a bond or a Cbranched, unbranched, or cyclic hydrocarbyl. Methods of preparing and using the polymer modified porous substrates are disclosed.

US Patent:

7927486, Apr 19, 2011

Filed:

Oct 9, 2007

Appl. No.:

11/973537

Inventors:

Vipul J. Shah - West Covina CA, US

Assignee:

Agilent Technologies, Inc - Santa Clara CA

International Classification:

B01D 15/08

US Classification:

2101982, 210635, 210656, 2105021

Abstract:

A polymer modified porous substrate for solid phase extraction or chromatography, comprising a porous substrate and a polymeric monolith formed thereon, wherein the polymeric monolith comprises Cmonocyclic or bicyclic aryl or heteroaryl, optionally substituted with -L-Q-R; where q is 0-3, p is 0-5, Q is —NRC(O)—, —C(O)NR—, —OC(O)NR—, —OC(O)R—, —NRC(O)O—, —NRC(O)NR—, —NCO, —CHOHCHOH—, CHOCHCHO—, —(CHCHO)—, —(CHCHCHO)—, —C(O)—, —C(O)O—, —CHC(O)CH—, —S—, —SS—, —CHOH—, —O—, —SO—, —SO—, —SO—, —OSO, —SONR—, —NR—, and —NR—, —CN, —NC, —CHOCH—, —NHC(NH)NH—, —NO, —NO, —OPO—, —OH; and R is hydrogen, Cmonocyclic or bicyclic aryl or heteroaryl, Cbranched, unbranched, or cyclic hydrocarbyl; L is a bond or a Cbranched, unbranched, or cyclic hydrocarbyl. Methods of preparing and using the polymer modified porous substrates are disclosed.

US Patent:

20060247361, Nov 2, 2006

Filed:

May 2, 2005

Appl. No.:

11/119840

Inventors:

Vipul Shah - West Covina CA, US

International Classification:

C08K 3/40

US Classification:

524494000, 524555000

Abstract:

A polar functionalized polymer modified porous substrate for solid phase extraction or chromatography, comprising a porous substrate and a polar functionalized polymeric monolith formed thereon, wherein the polymeric monolith comprises L-A-Pand L-Q-R—Pand optional L-A-L-Q-R units, wherein A is a Cmonocyclic or bicyclic aryl or heteroaryl, and Q is —NRC(O)—, —C(O)NR—, —OC(O)NR—, —OC(O)R—, —NRC(O)O—, —NRC(O)NR—, —NCO, —CHOHCHOH—, CHOCHCHO—, —(CHCHO)—, —(CHCHCHO)—, —C(O)—, —C(O)O—, —CHC(O)CH—, —S—, —SS—, —CHOH—, —O—, —SO—, —SO—, —SO—, —OSO, —SONR—, —NR—, and —NR—, —CN, —NC, —CHOCH—, —NHC(NH)NH—, —NO, —NO, —OPO—, —OH; r is 0 or 1; and R is hydrogen, Cmonocyclic or bicyclic aryl or heteroaryl, Cbranched, unbranched, or cyclic hydrocarbyl; L is a bond or a Cbranched, unbranched, or cyclic hydrocarbyl. Methods of preparing and using the polymer modified porous substrates are disclosed.