Virginia Johns Lee

US Patent:

6358681, Mar 19, 2002

Filed:

Oct 30, 1998

Appl. No.:

09/183636

Inventors:

Stephen Ginsberg - Philadelphia PA
John Q. Trojanowski - Philadelphia PA
Virginia M.-Y. Lee - Philadelphia PA
James Eberwine - Philadelphia PA

Assignee:

The Trustees of the University of Pennsylvania - Philadelphia PA

International Classification:

C12Q 168

US Classification:

435 6, 435 911, 435 912

Abstract:

Methods of detecting RNA in brain tissue of patients with Alzheimers disease are provided. Methods of diagnosing Alzheimers disease by detection of these RNAs are also provided.

US Patent:

7011827, Mar 14, 2006

Filed:

May 22, 2001

Appl. No.:

09/862204

Inventors:

Virginia M.-Y. Lee - Philadelphia PA, US
John Q. Trojanowski - Philadelphia PA, US

Assignee:

Trustees of the University of Pennsylvania - Philadelphia PA

International Classification:

A61K 35/00

US Classification:

424 931, 435325

Abstract:

Methods of treating individuals suspected of suffering from diseases, conditions or disorders of the Central Nervous System including nerve damage are provided wherein stable, homogeneous post-mitotic human neurons are into the individual's brain or at or near a site of nerve damage. Pharmaceutical compositions of stable, homogeneous post-mitotic human neurons and a pharmaceutically acceptable medium are also disclosed. Methods of generating non-human animal models of human CNS diseases, conditions or disorders by implanting stable, homogeneous post-mitotic human neurons into the brain of a non-human animal are disclosed. Non-human animals eith stable, homogeneous post-mitotic human neurons implanted in their brain are also disclosed.

US Patent:

7378111, May 27, 2008

Filed:

Feb 19, 2003

Appl. No.:

10/368769

Inventors:

Christopher J. Phiel - Royersford PA, US
Christina A. Wilson - Lansdowne PA, US
Virginia M-Y. Lee - Philadelphia PA, US
Peter S. Klein - Wynnewood PA, US

Assignee:

The Trustees of the University of Pennsylvania - Philadelphia PA

International Classification:

A61K 33/14
A61K 33/00
A61P 25/28

US Classification:

424677, 424722, 514879

Abstract:

Provided is a novel use of therapeutic concentrations of an inhibitor of glycogen synthase kinase-3 (GSK-3), including lithium or any other GSK-3 inhibitor, to block, reduce or inhibit processing of amyloid precursor proteins to beta-amyloid (Aβ) peptides, which are now believed to be the principal cause of Alzheimer's disease, thereby providing methods useful for the prevention, inhibition or reversal of the disease. Also provided are methods of using agents that specifically target the α isoform of GSK-3, which is responsible for APP processing, making such selective GSK-3α-specific inhibitors especially useful in the treatment, prevention, and possible reversal of Alzheimer's disease. Further provided are kits and screening methods associated with the present methods.

US Patent:

20020102594, Aug 1, 2002

Filed:

Jan 16, 2002

Appl. No.:

10/050229

Inventors:

Stephen Ginsberg - Philadelphia PA, US
John Trojanowski - Philadelphia PA, US
Virginia Lee - Philadelphia PA, US
James Eberwine - Philadelphia PA, US

International Classification:

C12Q001/68
C12P019/34

US Classification:

435/006000, 435/091200

Abstract:

Methods of detecting RNA in brain tissue of patients with Alzheimer's disease are provided. Methods of diagnosing Alzheimer's disease by detection of these RNAs are also provided.

US Patent:

20030186315, Oct 2, 2003

Filed:

Jun 28, 1999

Appl. No.:

09/297877

Inventors:

VIRGINIA M.-Y. LEE - PHILADELPHIA PA, US
ROBERT W. DOMS - BERWYN PA, US

International Classification:

G01N033/53

US Classification:

435/007100

Abstract:

secretase pathways which process amyloid precursor protein into the amyloid peptides of neuritic plaques and vascular deposits that accumulate in the brains of patients with Alzheimer's disease have been identified in the endoplasmic reticulum of neuronal cells. Methods of identifying compounds which increase or decrease processing of amyloid precursor protein via these pathways which may be useful in the treatment of Alzheimer's disease and in identifying causative agents of this disease are provided.

US Patent:

20030217370, Nov 20, 2003

Filed:

May 16, 2002

Appl. No.:

10/150043

Inventors:

Benoit Giasson - Lansdowne PA, US
John Trojanowski - Philadelphia PA, US
Virginia Lee - Philadelphia PA, US

International Classification:

A01K067/00

US Classification:

800/003000, 800/008000

Abstract:

The present invention relates to transgenic animals expressing A53T -Syn protein which are models for neurodegenerative disease progression. These animals may be used for screening candidate drug compounds effective against neurodegenerative diseases and other diseases involving -synucleinopathy.

US Patent:

20060029575, Feb 9, 2006

Filed:

Sep 29, 2005

Appl. No.:

11/242114

Inventors:

Virginia Lee - Philadelphia PA, US
John Trojanowski - Philadelphia PA, US

International Classification:

A61K 45/00
C12N 5/08

US Classification:

424093100, 435368000

Abstract:

Methods of treating individuals suspected of suffering from diseases, conditions or disorders of the Central Nervous System which comprise implanting stable, homogeneous post-mitotic human neurons into the individual's brain are disclosed. Methods of treating individuals suspected of suffering from injuries, diseases, conditions or disorders characterized by nerve damage which comprise implanting stable, homogeneous post-mitotic human neurons at or near a site of said nerve damage. Pharmaceutical compositions comprising stable, homogeneous post-mitotic human neurons and a pharmaceutically acceptable medium are disclosed. Methods of generating non-human animal models of human CNS diseases, conditions or disorders which comprise implanting stable, homogeneous post-mitotic human neurons into the brain of a non-human animal are disclosed. Non-human animals comprising stable, homogeneous post-mitotic human neurons implanted in their brain are disclosed.

US Patent:

20090263824, Oct 22, 2009

Filed:

Mar 26, 2009

Appl. No.:

12/412015

Inventors:

Virginia M.Y. Lee - Philadelphia PA, US
John Q. Trojanowski - Philadelphia PA, US

Assignee:

THE TRUSTEES OF THE UNIVERSITY OF PENNSYLVANIA - Philadelphia PA

International Classification:

G01N 33/53
C07K 16/00

US Classification:

435 71, 5303871

Abstract:

Provided are methods of assessing the absence or presence of a neurodegenerative disease in a subject comprising characterizing TDP-43 in a tissue sample of the subject. Also disclosed are methods for diagnosing a neurodegenerative disease in a subject, and methods for determining the efficacy of a drug against a neurodegenerative disease. Novel antibodies that bind to TDP-43 are also provided.