Walter W Jernigan

US Patent:

8180423, May 15, 2012

Filed:

Mar 29, 2006

Appl. No.:

11/392134

Inventors:

Andre Mang - Grenzach-Whylen, DE
Michael D. Garrison - Sparta NJ, US
Walter Jernigan - Indianapolis IN, US

Assignee:

Roche Diagnostics Operations, Inc. - Indianapolis IN

International Classification:

A61B 5/05

US Classification:

600345

Abstract:

Sensors and methods for producing them are disclosed. A cavity is created and filled with a reagent that includes a conductive matrix, enzyme, catalyst, and binding agent, in a preferred embodiment. The cavity is substantially enclosed, leaving enough of an opening to allow the sample to enter. A portion of the material surrounding the cavity is preferably permeable to a substance useful for measuring reaction, but not to the reagent or the sample. Cavities that have the shape of a cone, conical frustum, pyramidal frustum, and right circular cylinder are given as examples. Other systems include a membrane that contains the sensor's active area and defines an internal volume of fluid, where the membrane or internal volume has a particular geometric relationship to the active area.

US Patent:

8527024, Sep 3, 2013

Filed:

Dec 19, 2008

Appl. No.:

12/339945

Inventors:

Arnulf Staib - Heppenheim, DE
Reinhold Mischler - Ludwigshafen, DE
Martin Hajnsek - Graz, AT
Harvey Buck - Indianapolis IN, US
Walter Jernigan - Carmel IN, US

Assignee:

Roche Diagnostics Operations, Inc. - Indianapolis IN

International Classification:

G01N 33/487
G01N 27/49
G01N 27/26

US Classification:

600345, 2044031, 20440311, 20440313

Abstract:

An in vivo amperometric sensor is provided for measuring the concentration of an analyte in a body fluid. The sensor comprises a counter electrode and a working electrode, and the working electrode comprises a sensing layer which is generally water permeable and arranged on a support member adjacent to a contact pad. The sensing layer comprises an immobilized enzyme capable of acting catalytically in the presence of the analyte to cause an electrical signal. The sensing layer has an upper surface facing the body fluid and a lower surface facing away from the body fluid, and the immobilized enzyme is distributed within the sensing layer in such a way that the enzyme concentration in the middle between the upper and lower surfaces is at least as high as on the upper surface of the sensing layer.

US Patent:

20120209097, Aug 16, 2012

Filed:

Apr 26, 2012

Appl. No.:

13/456730

Inventors:

Andre MANG - Wachenheim, DE
Harvey B. BUCK - Indianapolis IN, US
Walter JERNIGAN - Carmel IN, US
Michael D. Garrison - Sparta NJ, US

International Classification:

A61B 5/1473

US Classification:

600345

Abstract:

Sensors and methods for producing them are disclosed. A cavity is created and filled with a reagent that includes a conductive matrix, enzyme, catalyst, and binding agent, in a preferred embodiment. The cavity is substantially enclosed, leaving enough of an opening to allow the sample to enter. A portion of the material surrounding the cavity is preferably permeable to a substance useful for measuring reaction, but not to the reagent or the sample. Cavities that have the shape of a cone, conical frustum, pyramidal frustum, and right circular cylinder are given as examples. Other systems include a membrane that contains the sensor's active area and defines an internal volume of fluid, where the membrane or internal volume has a particular geometric relationship to the active area.

US Patent:

58467025, Dec 8, 1998

Filed:

Dec 20, 1996

Appl. No.:

8/770975

Inventors:

Zhi David Deng - Carmel IN
Gerald F. Sigler - Carmel IN
Nigel A. Surridge - Indianapolis IN
Christopher D. Wilsey - Carmel IN
Robert J. McEnroe - Noblesville IN
Walter W. Jernigan - Indianapolis IN
Rebecca W. Muddiman - Indianapolis IN

Assignee:

Boehringer Mannheim Corporation - Indianapolis IN

International Classification:

C12Q 100
C12Q 154
C12Q 126

US Classification:

435 4

Abstract:

A new group of Os(II) and Os(III) compounds useful as redox mediators in electrochemical biosensors. These compounds have 1) low oxidation potential, 2) fast reaction kinetics between the electroactive center of an enzyme and the compound, 3) slow oxidation of osmium by oxygen, and 4) excellent solubility in aqueous medium. These mediators are particularly useful as a component of a reagent used in an electrochemical biosensor, wherein the biosensor is useful for measuring analytes from a biological fluid, such as blood.

US Patent:

56396317, Jun 17, 1997

Filed:

Jun 22, 1995

Appl. No.:

8/493727

Inventors:

Kenneth J. Dean - Carmel IN
Walter W. Jernigan - Indianapolis IN
William R. Carr - Indianapolis IN

Assignee:

Boehringer Mannheim Corporation - Indianapolis IN

International Classification:

C12Q 128
C12Q 154
C12Q 100
C12N 904

US Classification:

435 28

Abstract:

The invention is a stable reagent used in assay systems that form a colored ferric ion complex, such as Prussian Blue. Such reagents are useful for the detection or measurement of an analyte from a fluid sample. Surprisingly, it has been found that the inclusion of certain ferric ion chelating agents, such as 3-sulfobenzoic acid, will inhibit formation of the blank reaction in the reagent.

US Patent:

54340551, Jul 18, 1995

Filed:

May 6, 1994

Appl. No.:

8/239025

Inventors:

Walter Jernigan - Indianapolis IN

Assignee:

Boehringer Mannheim Corporation - Indianapolis IN

International Classification:

C12Q 160
C12Q 154
C12Q 126
C12Q 100

US Classification:

435 11

Abstract:

The invention describes a composition useful in determining sample analytes, where the determination is carried out anaerobically. The compositions include an analyte oxidizing agent, an electron transfer agent, ferric ions, and two chelators. The first chelator complexes to ferric ions, but does not have good affinity for ferrous ions. The second chelator does chelate ferrous ions, and forms a colored complex with the ion. It is the colored complex which serves as the indicator for the analyte. Different formulations of the composition are described.

US Patent:

55893260, Dec 31, 1996

Filed:

Dec 30, 1993

Appl. No.:

8/180492

Inventors:

Zhi D. Deng - Carmel IN
Gerald F. Sigler - Carmel IN
Nigel A. Surridge - Indianapolis IN
Christopher D. Wilsey - Carmel IN
Robert J. McEnroe - Noblesville IN
Walter W. Jernigan - Indianapolis IN
Rebecca W. Muddiman - Indianapolis IN

Assignee:

Boehringer Mannheim Corporation - Indianapolis IN

International Classification:

C12Q 100
C12Q 137
C12Q 126

US Classification:

435 4

Abstract:

A new group of Os(II) and Os(III) compounds useful as redox mediators in electrochemical biosensors. These compounds have 1) low oxidation potential, 2) fast reaction kinetics between the electroactive center of an enzyme and the compound, 3) slow oxidation of osmium by oxygen, and 4) excellent solubility in aqueous medium. These mediators are particularly useful as a component of a reagent used in an electrochemical biosensor, wherein the biosensor is useful for measuring analytes from a biological fluid, such as blood.

US Patent:

20190376922, Dec 12, 2019

Filed:

Aug 22, 2019

Appl. No.:

16/548361

Inventors:

- Indianapolis IN, US
Walter Jernigan - Carmel IN, US

International Classification:

G01N 27/327

Abstract:

A method is provided for verifying test element integrity includes providing a biosensor having an electrode-support substrate. A first electrode is provided on the substrate that includes a first body and a neck extending from the first body. A second electrode is provided on the substrate that includes a second body and an opposite pair of necks. Each of the necks extends from a respective end of the second body. A spacer is positioned on the substrate and has an edge defining a boundary of a capillary channel formed between a cover and the substrate. The method also includes applying a signal across the necks of the second electrode to verify continuity along the second electrode. The second body of the second electrode and the pair of connective necks surround the first electrode in the capillary channel forming a loop circuit around the first electrode.