Walter T Klimecki

US Patent:

20060069074, Mar 30, 2006

Filed:

Jul 7, 2005

Appl. No.:

11/176026

Inventors:

Robert Lemanske - Madison WI, US
Christine Sorkness - Madison WI, US
Vernon Chinchilli - Elizabethtown PA, US
Wenlei Liu - Palmyra PA, US
Brenda Phillips - Elizabethtown PA, US
Robert Zeiger - San Diego CA, US
Gregory Heldt - , US
Fernando Martinez - Tucson AZ, US
Walter Klimecki - Vail AZ, US
Theresa Guilbert - Tucson AZ, US
Wayne Morgan - Tucson AZ, US
Stanley Szefler - Aurora CO, US
Gary Larsen - Littleton CO, US
Lynn Taussig - Greenwood Village CO, US
Joseph Spahn - Denver CO, US
Robert Strunk - St. Louis MO, US
Leonard Bacharier - Town & Country MO, US
Gordon Bloomberg - St. Louis MO, US

International Classification:

A61K 31/56
A61K 31/47

US Classification:

514171000, 514311000

Abstract:

The present invention relates to methods for determining and predicting the efficacy of therapeutics for the treatment of an individual with asthma based on that individual's β-adrenergic receptor. The invention finds particular applicability to the treatment of an individual with asthma with an inhaled corticosteroid or a leukotriene receptor antagonist who is homozygous for arginine at position 16 of the β-adrenergic receptor.