Walter Jeffrey Shakespeare

US Patent:

6835004, Dec 28, 2004

Filed:

Aug 26, 2002

Appl. No.:

10/228650

Inventors:

Jason T. Iceman - Allentown PA
Walter Jeffery Shakespeare - Macungie PA
John Kai Andersen - Emmaus PA

Assignee:

T-Networks, Inc. - Allentown PA

International Classification:

G02B 636

US Classification:

385 92, 385 14, 361704, 361707, 361715, 257694, 257678, 257704, 257706, 257731, 257676, 257728, 174 5052, 174 521

Abstract:

An opto-electronic package is provided for mounting on a module base. The package comprises a generally rectangular package. An optical connector extends from a first side of the package body along an optical axis, generally parallel to the module base. A radio frequency connector extends from a second side of the package body along a RF axis, generally parallel to the module base. A plurality of electronic leads and mounting tabs each extend from at least one of the second side and a third side of the package body. A fourth side of the package body is adjacent the first side and free of connectors, leads, and mounting tabs for mounting the package in a corner of the module formed by first and second module walls. The fourth wall of the package body is positioned adjacent the first module wall and the optical connector extends through the second module wall.

US Patent:

7254429, Aug 7, 2007

Filed:

Aug 11, 2004

Appl. No.:

10/916236

Inventors:

Matthew J. Schurman - Somerset NJ, US
Walter J. Shakespeare - Macungie PA, US

Assignee:

GlucoLight Corporation - Bethlehem PA

International Classification:

A61B 5/00

US Classification:

600316

Abstract:

In accordance with the invention, a low coherence interferometer is used to non-invasively monitor the concentration of glucose in blood by shining a light over a surface area of human or animal tissue, continuously scanning the light over a two dimensional area of the surface, collecting the reflected light from within the tissue and constructively interfering this reflected light with light reflected along a reference path to scan the tissue in depth. Since the reflection spectrum is sensitive to glucose concentration at particular wavelengths, measurement and analysis of the reflected light provides a measure of the level of glucose in the blood. The measurement of glucose is taken from multiple depths within blood-profused tissue, and sensitivity is preferably enhanced by the use of multiple wavelengths. Noise or speckle associated with this technique is minimized by continuously scanning the illuminated tissue in area and depth.

US Patent:

7510849, Mar 31, 2009

Filed:

Jan 21, 2005

Appl. No.:

11/040388

Inventors:

Matthew J. Schurman - Somerset NJ, US
Walter Jeffrey Shakespeare - Macungie PA, US

Assignee:

GlucoLight Corporation - Bethlehem PA

International Classification:

C12Q 1/54

US Classification:

435 14, 424 91

Abstract:

This invention relates to a method of diagnosing or treating a biological subject, such as a person or animal, comprising the steps of subjecting at least a microsample of the subject's tissue to a physiological perturbation and measuring the response of the microsample to the perturbation using optical coherence tomography (OCT). In an exemplary embodiment, the concentration of glucose in the microsample is perturbed, as by providing the subject with a high glucose drink, and subsequently monitoring at a high sample rate in a microsample by OCT. Pathology, such as diabetes, can be diagnosed by deviation of the concentration vs. time response over several cells (micro-oscillation) from the micro-oscillation in the cells of a healthy subject. Other applications include diagnosing or treating de-hydration and diseases that cause changes in the osmolyte concentrations and thus the osmotic pressure in the cells in tissue.

US Patent:

7822452, Oct 26, 2010

Filed:

Apr 13, 2006

Appl. No.:

11/403635

Inventors:

Matthew J. Schurman - Somerset NJ, US
Walter J. Shakespeare - Macungie PA, US
William Henry Bennett - Bethlehem PA, US

Assignee:

GLT Acquisition Corp. - Irvine CA

International Classification:

A61B 5/1455

US Classification:

600316

Abstract:

The present invention relates to a method for estimating blood glucose levels using a noninvasive optical coherence tomography- (OCT-) based blood glucose monitor. An algorithm correlates OCT-based estimated blood glucose data with actual blood glucose data determined by invasive methods. OCT-based data is fit to the obtained blood glucose measurements to achieve the best correlation. Once the algorithm has generated sets of estimated blood glucose levels, it may refine the number of sets by applying one or more mathematical filters. The OCT-based blood glucose monitor is calibrated using an Intensity Difference plot or the Pearson Product Moment Correlation method.

US Patent:

8036727, Oct 11, 2011

Filed:

Jun 2, 2006

Appl. No.:

11/445631

Inventors:

Matthew J. Schurman - Somerset PA, US
Walter J. Shakespeare - Macungie PA, US
William Henry Bennett - Bethlehem PA, US

Assignee:

GLT Acquisition Corp. - Irvine CA

International Classification:

A61B 5/1455

US Classification:

600328, 600322, 600473

Abstract:

A method for noninvasively measuring analytes such as blood glucose levels includes using a non-imaging OCT-based system to scan a two-dimensional area of biological tissue and gather data continuously during the scanning. Structures within the tissue where measured-analyte-induced changes to the OCT data dominate over changes induced by other analytes are identified by focusing on highly localized regions of the data curve produced from the OCT scan which correspond to discontinuities in the OCT data curve. The data from these localized regions then can be related to measured analyte levels.

US Patent:

8049364, Nov 1, 2011

Filed:

Jun 4, 2008

Appl. No.:

12/133048

Inventors:

Walter Jeffrey Shakespeare - Macungie PA, US
Clarence William Crompton - Macungie PA, US

Assignee:

Electrikus, Inc. - Bethlehem PA

International Classification:

H02J 9/00

US Classification:

307 64

Abstract:

A substantially uninterruptible backup power system to provide power to common household appliances comprises a rechargeable battery, a trickle-charging circuit to keep the battery fully charged at all times from the receptacle power, a DC to AC inverter to supply standard AC line voltage from the battery to the lamp, a relay switch, controlled by main power voltage, to switch to the backup system when main power fails, and a timing circuit to optimize a voltage output of the system based on current battery voltage and a desired time period for the voltage output. The system can be set to operate only when the appliance is turned on, which optimizes the current and power required to provide backup power to the appliance for a maximum period of time.

US Patent:

8204566, Jun 19, 2012

Filed:

Aug 2, 2007

Appl. No.:

11/832721

Inventors:

Matthew J. Schurman - Somerset PA, US
Walter J. Shakespeare - Macungie PA, US

Assignee:

GLT Acquisition Corp. - Irvine CA

International Classification:

A61B 5/1455

US Classification:

600322, 600310, 600316

Abstract:

In accordance with the invention, a low coherence interferometer is used to non-invasively monitor the concentration of glucose in blood by shining a light over a surface area of human or animal tissue, continuously scanning the light over a two dimensional area of the surface, collecting the reflected light from within the tissue and constructively interfering this reflected light with light reflected along a reference path to scan the tissue in depth. Since the reflection spectrum is sensitive to glucose concentration at particular wavelengths, measurement and analysis of the reflected light provides a measure of the level of glucose in the blood. The measurement of glucose is taken from multiple depths within blood-profused tissue, and sensitivity is preferably enhanced by the use of multiple wavelengths. Noise or speckle associated with this technique is minimized by continuously scanning the illuminated tissue in area and depth.

US Patent:

8219172, Jul 10, 2012

Filed:

Mar 17, 2006

Appl. No.:

11/378538

Inventors:

Matthew J. Schurman - Somerset PA, US
Phillip William Wallace - Bernardsville NJ, US
Walter J. Shakespeare - Macungie PA, US
Howard P. Apple - Winter Park FL, US
William Henry Bennett - Bethlehem PA, US

Assignee:

GLT Acquisition Corp. - Irvine CA

International Classification:

A61B 5/1455

US Classification:

600344, 600310, 600316

Abstract:

A system and a method for creating a stable and reproducible interface of an optical sensor system for measuring blood glucose levels in biological tissue include a dual wedge prism sensor attached to a disposable optic that comprises a focusing lens and an optical window. The disposable optic adheres to the skin to allow a patient to take multiple readings or scans at the same location. The disposable optic includes a Petzval surface placed flush against the skin to maintain the focal point of the optical beam on the surface of the skin. Additionally, the integrity of the sensor signal is maximized by varying the rotation rates of the dual wedge prisms over time in relation to the depth scan rate of the sensor. Optimally, a medium may be injected between the disposable and the skin to match the respective refractive indices and optimize the signal collection of the sensor.