Wei H He

US Patent:

6826483, Nov 30, 2004

Filed:

Oct 13, 2000

Appl. No.:

09/687813

Inventors:

Roger N. Anderson - Palisades NY
Albert Boulanger - Palisades NY
Wei He - Palisades NY
Jody Winston - Palisades NY
Liquing Xu - Palisades NY
Ulisses Mello - Yorktown Heights NY
Wendell Wiggins - Houston TX

Assignee:

The Trustees of Columbia University in the City of New York - New York NY

International Classification:

G01V 128

US Classification:

702 13, 702 14

Abstract:

A single intranet, internet, or World Wide Web-accessible interface is provided for, initiation of, interactive adjustments to, and access to the outputs of an integrated workflow of a plurality of analytical computer applications for characterization and analysis of traits and optimal management of the extraction of oil, gas, and water from a subsurface reservoir. By combining disparate analytical application tools in a seamless and remotely accessible, package, incompatibility problems caused by the disparate nature of petroleum analysis methods is reduced. The assumptions, analytic processes, and input data used for one analysis may be readily retrieved and re-evaluated for that reservoir or for future evaluations of the same or other reservoirs. Thus a flexible database of analysis tools and data may be implemented for access, input, and output of workflow and analytical data in the field, in conjunction with standard main computer servers, software and plug-ins, and portable remote computers.

US Patent:

8309299, Nov 13, 2012

Filed:

May 2, 2011

Appl. No.:

13/098527

Inventors:

John Frederick Boylan - Bedminster NJ, US
Wei He - New York NY, US

Assignee:

Hoffmann-La Roche Inc. - Nutley NJ

International Classification:

C12Q 1/68
G01N 33/53
G01N 33/68

US Classification:

435 4, 435 61, 435 617, 435 71

Abstract:

The present invention relates to a method for determining a subject's resistance to treatment with 2,2-dimethyl-N-((S)-6-oxo-6,7-dihydro-5H-dibenzo[b,d]azepin-7-yl)-N′-(2,2,3,3,3-pentafluoro-propyl)-malonamide by measuring the levels a biomarker or biomarkers present in a biological sample obtained from the subject, the biomarker being IL6 and/or IL8. The present invention also relates to a combination therapy for a patient suffering from a proliferative disorder comprising administering to the patient 2,2-Dimethyl-N-((S)-6-oxo-6,7-dihydro-5H-dibenzo[b,d]azepin-7-yl)-N′-(2,2,3,3,3-pentafluoro-propyl)-malonamide and an anti-IL6 and/or an anti-IL8 agent.

US Patent:

8318565, Nov 27, 2012

Filed:

Mar 11, 2010

Appl. No.:

12/721608

Inventors:

Huiming Bu - Millwood NY, US
Michael P. Chudzik - Danbury CT, US
Wei He - Fishkill NY, US
William K. Henson - Beacon NY, US
Siddarth A. Krishnan - Hopewell Junction NY, US
Unoh Kwon - Fishkill NY, US
Naim Moumen - Walden NY, US
Wesley C. Natzle - New Paltz NY, US

Assignee:

International Business Machines Corporation - Armonk NY

International Classification:

H01L 21/336

US Classification:

438287, 438591, 257E21192

Abstract:

Methods for fabricating gate electrode/high-k dielectric gate structures having an improved resistance to the growth of silicon dioxide (oxide) at the dielectric/silicon-based substrate interface. In an embodiment, a method of forming a transistor gate structure comprises: incorporating nitrogen into a silicon-based substrate proximate a surface of the substrate; depositing a high-k gate dielectric across the silicon-based substrate; and depositing a gate electrode across the high-k dielectric to form the gate structure. In one embodiment, the gate electrode comprises titanium nitride rich in titanium for inhibiting diffusion of oxygen.

US Patent:

8440652, May 14, 2013

Filed:

Mar 2, 2012

Appl. No.:

13/410407

Inventors:

David John Augeri - Princeton NJ, US
Jeffrey Thomas Bagdanoff - Martinez CA, US
Simon David Peter Baugh - Ringoes NJ, US
Marianne Carlsen - Yardley PA, US
Kenneth Gordon Carson - Princeton NJ, US
John Anthony Gilleran - Bridgewater NJ, US
Wei He - Lawrenceville NJ, US
Tamas Oravecz - The Woodlands TX, US
Leonard Sung - Hopewell NJ, US

Assignee:

Lexicon Pharmaceuticals, Inc. - The Woodlands TX

International Classification:

C07D 401/14
C07D 495/04
A61K 31/4418
A61K 31/444

US Classification:

51421105, 514309, 514352, 514334, 51425505, 514333, 514221, 514301, 51421207, 544405, 546141, 546309, 546257, 546256, 546114, 540504, 540490

Abstract:

Compounds for the inhibition of mammalian Ste20-like kinase 1 (MST1) are disclosed, along with compositions comprising them and methods of their use in the treatment, management or prevention of an inflammatory or autoimmune diseases or disorders. Particular compounds are of the formula:.

US Patent:

8560476, Oct 15, 2013

Filed:

Jan 24, 2008

Appl. No.:

12/019347

Inventors:

Roger N. Anderson - New York NY, US
Albert Boulanger - New York NY, US
Wei He - Tappan NY, US
Ulisses Mello - Yorktown Heights NY, US
Liqing Xu - Tenafly NJ, US

Assignee:

The Trustees of Columbia University in the City of New York - New York NY

International Classification:

G06F 17/00
G06N 5/00
G06G 7/48

US Classification:

706 45, 703 10

Abstract:

A computer-aided lean management (CALM) controller system recommends actions and manages production in an oil and gas reservoir/field as its properties and conditions change with time. The reservoir/field is characterized and represented as an electronic-field (“e-field”). A plurality of system applications describe dynamic and static e-field properties and conditions. The application workflows are integrated and combined in a feedback loop between actions taken in the field and metrics that score the success or failure of those actions. A controller/optimizer operates on the combination of the application workflows to compute production strategies and actions. The controller/optimizer is configured to generate a best action sequence for production, which is economically “always-in-the-money. ”.

US Patent:

8575709, Nov 5, 2013

Filed:

Jul 24, 2012

Appl. No.:

13/556795

Inventors:

Huiming Bu - Millwood NY, US
Michael P. Chudzik - Danbury CT, US
Wei He - Fishkill NY, US
William K. Henson - Beacon NY, US
Siddarth A. Krishnan - Hopewell Junction NY, US
Unoh Kwon - Fishkill NY, US
Naim Moumen - Walden NY, US
Wesley C. Natzle - New Paltz NY, US

Assignee:

International Business Machines Corporation - Armonk NY

International Classification:

H01L 29/78

US Classification:

257411, 257412, 257E2916

Abstract:

Methods for fabricating gate electrode/high-k dielectric gate structures having an improved resistance to the growth of silicon dioxide (oxide) at the dielectric/silicon-based substrate interface. In an embodiment, a method of forming a transistor gate structure comprises: incorporating nitrogen into a silicon-based substrate proximate a surface of the substrate; depositing a high-k gate dielectric across the silicon-based substrate; and depositing a gate electrode across the high-k dielectric to form the gate structure. In one embodiment, the gate electrode comprises titanium nitride rich in titanium for inhibiting diffusion of oxygen.

US Patent:

20110112176, May 12, 2011

Filed:

Nov 5, 2010

Appl. No.:

12/940083

Inventors:

John Frederick Boylan - Bedminster NJ, US
Birgit Bramlage - Kulmbach, DE
Wei He - New York NY, US
Markus Hossbach - Kulmbach, DE
Ingo Roehl - Memmelsdorf, DE

International Classification:

A61K 31/713
C07H 21/02
C12N 15/63
C12N 5/10
A61P 35/00

US Classification:

514 44 R, 536 231, 4353201, 435365

Abstract:

The invention relates to a double-stranded ribonucleic acid (dsRNA) for inhibiting the expression of a KIF10 gene. The invention also relates to a pharmaceutical composition comprising the dsRNA or nucleic acid molecules or vectors encoding the same together with a pharmaceutically acceptable carrier; methods for treating diseases caused by the expression of a KIF10 gene using said pharmaceutical composition; and methods for inhibiting the expression of KIF10 in a cell.

US Patent:

20130072543, Mar 21, 2013

Filed:

Jul 5, 2012

Appl. No.:

13/541891

Inventors:

John Frederick Boylan - Bedminster NJ, US
Wei He - Livingston NJ, US

Assignee:

ARROWHEAD RESEARCH CORPORATION - Pasadena CA

International Classification:

A61K 47/22

US Classification:

514 44 A, 977773

Abstract:

The invention relates to compositions containing compounds of formula I:and pharmaceutically acceptable salts thereof, wherein R, R, R, R, and n are defined in the detailed description and claims. In addition, the present invention relates to novel formulations containing compounds of formula I for improved delivery of nucleic acids such as siRNA to the cytoplasm of target cells. In particular embodiments these formulations comprise compounds of formula I, phospholipids, cholesterol, and pegylated lipids. The present invention also relates to methods of manufacturing and using such compounds and compositions.