Wei H He

US Patent:

6482834, Nov 19, 2002

Filed:

Apr 6, 2001

Appl. No.:

09/828633

Inventors:

Alfred P. Spada - Lansdale PA
Wei He - Collegeville PA
Michael R. Myers - Reading PA

Assignee:

Aventis Pharmaceuticals Inc. - Bridgewater NJ

International Classification:

A61K 3147

US Classification:

514311, 514312, 514313, 514314, 546153, 546159, 546171, 546178, 546179

Abstract:

This invention is directed to quinoline/quinoxaline compounds which inhibit platelet-derived growth factor or p56 tyrosine kinase activity, to pharmaceutical compositions comprising these compounds, and to the use of these compounds for treating a patient suffering from or subject to disorders/conditions involving cellular differentiation, proliferation, extracellular matrix production or mediator release and/or T cell activation and proliferation.

US Patent:

7041681, May 9, 2006

Filed:

Mar 26, 2003

Appl. No.:

10/400006

Inventors:

Henry J. Breslin - Lansdale PA, US
Wei He - Audubon PA, US
Robert W. Kavash - Glenside PA, US

Assignee:

Janssen Pharmaceutica N.V. - Beerse

International Classification:

A61K 31/454
A61K 31/4725
C07D 401/04
C07D 401/14

US Classification:

514326, 546210, 546187, 546146, 544 60, 544128, 544129, 544360, 544363, 514316, 514307, 514252, 5142355, 5142278

Abstract:

This invention is directed towards novel compounds as opioid receptor modulators, antagonists, and agonists useful for the treatment of opioid modulated disorders such as pain and gastrointestinal disorders.

US Patent:

7202381, Apr 10, 2007

Filed:

Mar 14, 2005

Appl. No.:

11/079573

Inventors:

Henry J. Breslin - Lansdale PA, US
Wei He - Audubon PA, US
Robert W. Kavash - Glenside PA, US

Assignee:

Janssen Pharmaceutica, NV

International Classification:

C07C 53/134
C07D 213/24

US Classification:

562496, 546314, 562443, 562448, 560 38, 564182

Abstract:

This invention is directed towards novel compounds as opioid receptor modulators, antagonists, and agonists useful for the treatment of opioid modulated disorders such as pain and gastrointestinal disorders.

US Patent:

7629488, Dec 8, 2009

Filed:

Mar 6, 2006

Appl. No.:

11/368564

Inventors:

Chaozhong Cai - North Wales PA, US
Wei He - Audubon PA, US

Assignee:

Janssen Pharmaceutica N.V. - Beerse

International Classification:

C07C 51/10

US Classification:

562406, 562400, 562405

Abstract:

The present invention is directed to novel processes for the preparation of opioid modulators (agonists and antagonists) and intermediates in their synthesis. The opioid modulators are useful for the treatment and prevention of as pain and gastrointestinal disorders.

US Patent:

7659402, Feb 9, 2010

Filed:

Oct 4, 2005

Appl. No.:

11/242763

Inventors:

Henry J. Breslin - Lansdale PA, US
Wei He - Audubon PA, US
Robert W. Kavash - Glenside PA, US

Assignee:

Janssen Pharmaceutica, NV

International Classification:

C07D 217/00

US Classification:

546146

Abstract:

This invention is directed towards novel compounds as opioid receptor modulators, antagonists, and agonists useful for the treatment of opioid modulated disorders such as pain and gastrointestinal disorders.

US Patent:

7741356, Jun 22, 2010

Filed:

Mar 14, 2005

Appl. No.:

11/079647

Inventors:

Henry J. Breslin - Lansdale PA, US
Chaozhong Cai - N. Wales PA, US
Wei He - Audubon PA, US
Robert W. Kavash - Glenside PA, US

Assignee:

Janssen Pharmaceutica N.V. - Beerse

International Classification:

A61K 31/4174
A61K 31/4178
C07D 233/64

US Classification:

514396, 514397, 5483355

Abstract:

The present invention is directed to novel opioid receptor modulators of Formula (I). The invention further relates to methods for preparing such compounds, pharmaceutical compositions containing them, and their use in the treatment of disorders that may be ameliorated or treated by the modulation of opioid receptors.

US Patent:

8344011, Jan 1, 2013

Filed:

Jul 19, 2010

Appl. No.:

12/838825

Inventors:

Henry J. Breslin - Lansdale PA, US
Chaozhong Cai - North Wales PA, US
Wei He - Audubon PA, US
Robert W. Kavash - Glenside PA, US

Assignee:

Janssen Pharmaceutica, N.V. - Beerse

International Classification:

A61K 31/4174
A61K 31/4178
C07D 233/64

US Classification:

514396, 514397, 5483355

Abstract:

The present invention is directed to novel opioid receptor modulators of Formula (I). The invention further relates to methods for preparing such compounds, pharmaceutical compositions containing them, and their use in the treatment of disorders that may be ameliorated or treated by the modulation of opioid receptors.

US Patent:

8383629, Feb 26, 2013

Filed:

Feb 26, 2009

Appl. No.:

12/919370

Inventors:

David A. Claremon - Maple Glen PA, US
Colin M. Tice - Ambler PA, US
Yuanjie Ye - Ambler PA, US
Suresh B. Singh - Kendall Park NJ, US
Wei He - Audubon PA, US
Wei Zhao - Eagleville PA, US
Robert D. Simpson - Wilmington DE, US

Assignee:

Vitae Pharmaceuticals, Inc. - Fort Washington PA

International Classification:

A61K 31/497
A61K 31/44
C07D 241/04
C07D 401/04

US Classification:

51425303, 514278, 544230, 546 17, 546 18

Abstract:

This invention relates to novel compounds of the Formulae I or II and pharmaceutically acceptable salts thereof, and pharmaceutical compositions thereof which are useful for the therapeutic treatment of diseases associated with the modulation or inhibition of 11 β-HSD 1 in mammals. Formula (I).