Wei He

US Patent:

6482834, Nov 19, 2002

Filed:

Apr 6, 2001

Appl. No.:

09/828633

Inventors:

Alfred P. Spada - Lansdale PA
Wei He - Collegeville PA
Michael R. Myers - Reading PA

Assignee:

Aventis Pharmaceuticals Inc. - Bridgewater NJ

International Classification:

A61K 3147

US Classification:

514311, 514312, 514313, 514314, 546153, 546159, 546171, 546178, 546179

Abstract:

This invention is directed to quinoline/quinoxaline compounds which inhibit platelet-derived growth factor or p56 tyrosine kinase activity, to pharmaceutical compositions comprising these compounds, and to the use of these compounds for treating a patient suffering from or subject to disorders/conditions involving cellular differentiation, proliferation, extracellular matrix production or mediator release and/or T cell activation and proliferation.

US Patent:

7041681, May 9, 2006

Filed:

Mar 26, 2003

Appl. No.:

10/400006

Inventors:

Henry J. Breslin - Lansdale PA, US
Wei He - Audubon PA, US
Robert W. Kavash - Glenside PA, US

Assignee:

Janssen Pharmaceutica N.V. - Beerse

International Classification:

A61K 31/454
A61K 31/4725
C07D 401/04
C07D 401/14

US Classification:

514326, 546210, 546187, 546146, 544 60, 544128, 544129, 544360, 544363, 514316, 514307, 514252, 5142355, 5142278

Abstract:

This invention is directed towards novel compounds as opioid receptor modulators, antagonists, and agonists useful for the treatment of opioid modulated disorders such as pain and gastrointestinal disorders.

US Patent:

7202381, Apr 10, 2007

Filed:

Mar 14, 2005

Appl. No.:

11/079573

Inventors:

Henry J. Breslin - Lansdale PA, US
Wei He - Audubon PA, US
Robert W. Kavash - Glenside PA, US

Assignee:

Janssen Pharmaceutica, NV

International Classification:

C07C 53/134
C07D 213/24

US Classification:

562496, 546314, 562443, 562448, 560 38, 564182

Abstract:

This invention is directed towards novel compounds as opioid receptor modulators, antagonists, and agonists useful for the treatment of opioid modulated disorders such as pain and gastrointestinal disorders.

US Patent:

7629488, Dec 8, 2009

Filed:

Mar 6, 2006

Appl. No.:

11/368564

Inventors:

Chaozhong Cai - North Wales PA, US
Wei He - Audubon PA, US

Assignee:

Janssen Pharmaceutica N.V. - Beerse

International Classification:

C07C 51/10

US Classification:

562406, 562400, 562405

Abstract:

The present invention is directed to novel processes for the preparation of opioid modulators (agonists and antagonists) and intermediates in their synthesis. The opioid modulators are useful for the treatment and prevention of as pain and gastrointestinal disorders.

US Patent:

7659402, Feb 9, 2010

Filed:

Oct 4, 2005

Appl. No.:

11/242763

Inventors:

Henry J. Breslin - Lansdale PA, US
Wei He - Audubon PA, US
Robert W. Kavash - Glenside PA, US

Assignee:

Janssen Pharmaceutica, NV

International Classification:

C07D 217/00

US Classification:

546146

Abstract:

This invention is directed towards novel compounds as opioid receptor modulators, antagonists, and agonists useful for the treatment of opioid modulated disorders such as pain and gastrointestinal disorders.

US Patent:

7741356, Jun 22, 2010

Filed:

Mar 14, 2005

Appl. No.:

11/079647

Inventors:

Henry J. Breslin - Lansdale PA, US
Chaozhong Cai - N. Wales PA, US
Wei He - Audubon PA, US
Robert W. Kavash - Glenside PA, US

Assignee:

Janssen Pharmaceutica N.V. - Beerse

International Classification:

A61K 31/4174
A61K 31/4178
C07D 233/64

US Classification:

514396, 514397, 5483355

Abstract:

The present invention is directed to novel opioid receptor modulators of Formula (I). The invention further relates to methods for preparing such compounds, pharmaceutical compositions containing them, and their use in the treatment of disorders that may be ameliorated or treated by the modulation of opioid receptors.

US Patent:

7902358, Mar 8, 2011

Filed:

Dec 28, 2006

Appl. No.:

11/647091

Inventors:

Steven J. Coats - McDonough GA, US
Alexey B. Dyatkin - Maple Glen PA, US
Wei He - Audubon PA, US
Joseph Lisko - Glenmoore PA, US
Tamara Miskowski - Chalfont PA, US
Janet L. Ralbovsky - Yorktown Heights NY, US
Mark Schulz - Skippack PA, US

Assignee:

Janssen Pharmaceutica NV - Beerse

International Classification:

C07D 401/06
C07D 401/12
C07D 401/14
C07D 403/06
C07D 403/12
C07D 403/14
A61K 31/506
A61P 1/00
A61P 1/06

US Classification:

544223, 514245, 514241, 544220

Abstract:

The present invention relates to certain novel compounds of Formula (I):.

US Patent:

7968710, Jun 28, 2011

Filed:

Mar 14, 2006

Appl. No.:

11/375407

Inventors:

Steven J. Coats - Quakertown PA, US
Alexey B. Dyatkin - Maple Glen PA, US
Wei He - Audubon PA, US
Joseph Lisko - Collegeville PA, US
Tamara A. Miskowski - Chalfont PA, US
Janet L. Ralbovsky - North Wales PA, US
Mark J. Schulz - Skippack PA, US

Assignee:

Janssen Pharmaceutica NV - Beerse

International Classification:

C07D 251/30
C07D 401/06
C07D 401/14
C07D 403/06
C07D 403/14
C07D 401/12
C07D 403/12
A61K 31/53
A61P 1/12
A61P 1/06
A61P 1/00

US Classification:

544223, 544220, 514245, 514241

Abstract:

The present invention relates to certain novel compounds of Formula (I):.