Wei Li Zhang

US Patent:

7257563, Aug 14, 2007

Filed:

Jan 30, 2003

Appl. No.:

10/354907

Inventors:

Ilya Shmulevich - Houston TX, US
Edward R. Dougherty - College Station TX, US
Wei Zhang - Houston TX, US

Assignee:

The Board of Regents of The University of Texas - Austin TX
The Texas A&M University System - College Station TX

International Classification:

G06E 1/00
G06E 3/00
G06F 15/18
G06G 7/00
G06N 3/02

US Classification:

706 15

Abstract:

Embodiments of the invention encompass methods for modeling of complex systems, which include, but are not limited to gene regulatory networks, biological systems, and the like. Other embodiments of the invention include the development of computational tools for the identification and discovery of potential targets for therapeutic intervention in diseases such as cancer. The embodiments discussed utilize methods that model the potential effect of individual genes on the global dynamical network behavior, both from the view of random gene mutation as well as intervention in order to elicit desired network behavior.

US Patent:

7341552, Mar 11, 2008

Filed:

Mar 17, 2003

Appl. No.:

10/390343

Inventors:

Wei Zhang - Houston TX, US
Greg Fuller - Houston TX, US
Ed Dougherty - College Station TX, US
Kenneth Hess - Houston TX, US

Assignee:

The University of Texas System Board of Regents - Austin TX
The Texas A & M University System - College Station TX

International Classification:

C40B 30/00

US Classification:

506 7, 435 6

Abstract:

The present invention provides a number of gene markers whose expression is altered in various gliomas. In particular, by examining the expression these markers, one can accurately classify a glioma as glioblastoma multiforme (GM), anaplastic astrocytoma (AA), anaplastic oligodendroglioma (AO) or oligodendroglioma (OL). The diagnosis may be performed on nucleic acids, for example, using a DNA microarray, or on protein, for example, using immunologic means. Also disclosed are methods of therapy.

US Patent:

20030108920, Jun 12, 2003

Filed:

Sep 9, 2002

Appl. No.:

10/237566

Inventors:

Wei Zhang - Houston TX, US
Wei Song - Houston TX, US
Greg Fuller - Houston TX, US

International Classification:

A61K048/00
A61K038/17
A01K067/027
C12Q001/68
G01N033/574
C12P021/02
C12N005/06
C07K014/47

US Classification:

435/006000, 435/007230, 435/069100, 435/320100, 435/325000, 514/044000, 514/012000, 530/350000, 536/023200, 800/018000

Abstract:

The present invention provides the identification of a tumor suppressor protein that binds to IGFBP2. This 388 amino acid protein, designated 86, contains an ICE-p20 domain, and is expressed in a number of normal tissues, include spleen, placenta, stomach, brain (including cerebellum) and liver. It also is expressed, ocassionally with a splice variant lacking a single exon, in various cancer cells including gliomas. Thus, methods for diagnosing and treating cancers having defects in the 86 gene are disclosed, as are methods for screening compounds for their ability to modulate 86 expression and function.

US Patent:

20030175724, Sep 18, 2003

Filed:

Apr 25, 2002

Appl. No.:

10/132660

Inventors:

Wei Zhang - Houston TX, US
Limei Hu - Pearland TX, US
Stanley Hamilton - Bellaire TX, US

International Classification:

C12Q001/68
G01N033/53
C07H021/04
C12P019/34

US Classification:

435/006000, 435/007100, 435/091200, 536/024300

Abstract:

The present invention provides methods for the identification of promoters and transcription initiation sites. More particularly, the invention provides for the production of a promoter library, and uses of the library in the identification of transcription factors that interact with previously unidentified promoter elements.

US Patent:

20120167692, Jul 5, 2012

Filed:

Jul 30, 2009

Appl. No.:

13/386338

Inventors:

Christopher M. Jones - Houston TX, US
Michael T. Pelletier - Houston TX, US
Robert Atkinson - Richmond TX, US
Wei Zhang - Houston TX, US
Li Gao - Katy TX, US

Assignee:

Haliburton Energy Services Inc. - Houston TX

International Classification:

G01H 17/00
G01R 19/00
G01J 1/04
G01N 23/06
G01J 1/02
G01T 3/00

US Classification:

73646, 250216, 25039001, 250577, 25022711, 250311, 324 7611

Abstract:

Apparatus, systems, and methods may operate to receive incident energy within a chamber defining a first part of an interaction volume that attenuates the incident energy as a function of path length to provide attenuated energy. Additional activity may include simultaneously transforming the attenuated energy characterized by a substantially exponential intensity function into resultant energy characterized by a substantially polynomial intensity function. The transformation may be accomplished using an interacted energy transformation element that defines a second part of the interaction volume, the transformation element operating to intercept the attenuated energy along a plurality of path lengths. Other activity may include transmitting the resultant energy to a receiver. Additional apparatus, systems, and methods are disclosed.

US Patent:

20120211650, Aug 23, 2012

Filed:

Nov 18, 2010

Appl. No.:

13/502805

Inventors:

Christopher M. Jones - Houston TX, US
Stephen A. Zannoni - Houston TX, US
Michael T. Pelletier - Houston TX, US
Raj Pai - Houston TX, US
Wei Zhang - Houston TX, US
Marina L. Morys - Downingtown PA, US

Assignee:

Halliburton Energy Services ,Inc. - Houston TX

International Classification:

G01V 8/02

US Classification:

2502691

Abstract:

Various methods and tools optically analyze downhole fluid properties in situ. Some disclosed downhole optical radiometry tools include a tool body having a sample cell for fluid flow. A light beam passes through the sample cell and a spectral operation unit (SOU) such as a prism, filter, interferometer, or multivariate optical element (MOE). The resulting light provides a signal indicative of one or more properties of the fluid. A sensor configuration using electrically balanced thermopiles offers a high sensitivity over a wide temperature range. Further sensitivity is achieved by modulating the light beam and/or by providing a reference light beam that does not interact with the fluid flow. To provide a wide spectral range, some embodiments include multiple filaments in the light source, each filament having a different emission spectrum. Moreover, some embodiments include a second light source, sample cell, SOU, and detector to provide increased range, flexibility, and reliability.

US Patent:

20130046473, Feb 21, 2013

Filed:

Aug 19, 2011

Appl. No.:

13/213195

Inventors:

Wei Zhang - Houston TX, US
Christopher M. Jones - Houston TX, US
Michael T. Pelletier - Houston TX, US
Robert S. Atkinson - Richmond TX, US
Stephen A. Zannoni - Houston TX, US

Assignee:

HALLIBURTON ENERGY SERVICES INC. - Houston TX

International Classification:

G06F 19/00

US Classification:

702 6

Abstract:

A processor accepts sensor data about a geological formation from a sensor. The sensor data is such that processing the sensor data using a processing technique to estimate a parameter of the geological formation without a constraint, whose value is not yet known, produces a plurality of non-unique estimates of the parameter. The processor accepts more than two time-displaced images of fluid sampled from the geological formation. The time displacements between the images are substantially defined by a mathematical series. The processor processes the images to determine the constraint. The processor processes the sensor data using the processing technique constrained by the constraint to estimate the parameter of the geological formation. The processor uses the estimated parameter to affect the drilling of a well through the geological formation.

US Patent:

20140070083, Mar 13, 2014

Filed:

May 24, 2011

Appl. No.:

14/117542

Inventors:

Wei Zhang - Houston TX, US
Robert Atkinson - Richmond TX, US
Michael T. Pelletier - Houston TX, US
Christopher M. Jones - Houston TX, US

Assignee:

HALLIBURTON ENERGY SERVICES, INC. - Houston TX

International Classification:

G01N 21/25
G02B 26/00
G01V 8/00

US Classification:

250256, 359891

Abstract:

Downhole spectrometer tools are provided with two ways to increase the number of filters on an optical path. A first approach employs multiple filter wheels that rotate alternately in a common plane to intersect the optical path. Portions of the wheels are cut out to avoid mechanical interference between the wheels. A second approach drives the one or more filter wheels with a wobble that causes the filters to trace one or more hypocycloidal curves that each intersect the optical path.