Weixin Lu

US Patent:

6342216, Jan 29, 2002

Filed:

Mar 17, 1999

Appl. No.:

09/271013

Inventors:

Isaiah J. Fidler - Houston TX
Zhongyun Dhong - Sugarland TX
Weixin Lu - Houston TX

Assignee:

The Board of Regents, The University of Texas System - Austin TX

International Classification:

A61K 4800

US Classification:

424 9321, 424 931, 424 932, 424 691, 424 695, 424 6951, 424 6952, 4353201, 435455, 435456, 435325, 435348, 536 231, 536 235, 536 2352

Abstract:

Provided are compositions and methods of use for insect cells comprising baculovirus encoding non-surface expressed proteins and peptides. The claimed invention particularly relates to compositions comprising insect cells containing baculovirus that express cytokines. Such compositions may be administered by, for example, direct intratumoral injection into tumors in mammals, resulting in tumor reduction or recission. Another aspect of the claimed invention concerns methods of promoting resistance to the reoccurence of tumors in mammals who have undergone such tumor recission. In a specific aspect of the claimed invention, the mammals are human subjects presenting with various forms of cancer.

US Patent:

6872385, Mar 29, 2005

Filed:

May 31, 2001

Appl. No.:

09/872162

Inventors:

Isaiah J. Fidler - Houston TX, US
Zhongyun Dong - Sugar Land TX, US
Weixin Lu - Houston TX, US

Assignee:

Board of Regents, The University of Texas System - Austin TX

International Classification:

A61K038/21
A61K048/00
A61K045/00
A01N063/00
C12N015/63

US Classification:

424 856, 424 9321, 424 933, 4242781, 4353201, 435455

Abstract:

Disclosed are methods and compositions useful in the recruitment, activation and initiation of proliferation of immune cells. The instant invention relates to the discovery that specific insect cells and insect cell compositions exhibit adjuvant properties. The added benefit of this system is that the insect cells utilized may be transformed with an expression system and thus proteins may be introduced into the composition through direct protein expression by the cells. The claimed compositions and methods are particularly relevant in anti-tumor and cancer therapy. Of specific interest is the ability of the compositions of the invention to elicit a response that controls not only the primary tumor but also any metastatic cells or metastatic tumors which subsequently arise.

US Patent:

20050232906, Oct 20, 2005

Filed:

Mar 29, 2005

Appl. No.:

11/093269

Inventors:

Isaiah Fidler - Houston TX, US
Zhongyun Dong - Sugar Land TX, US
Weixin Lu - Houston TX, US

International Classification:

A61K048/00
A61K038/21
A61K038/20
C12N015/86
C12N005/08

US Classification:

424093210, 435366000, 435455000, 424085200, 424085700

Abstract:

Disclosed are methods and compositions useful in the recruitment, activation and initiation of proliferation of immune cells. The instant invention relates to the discovery that specific insect cells and insect cell compositions exhibit adjuvant properties. The added benefit of this system is that the insect cells utilized may be transformed with an expression system and thus proteins may be introduced into the composition through direct protein expression by the cells. The claimed compositions and methods are particularly relevant in anti-tumor and cancer therapy. Of specific interest is the ability of the compositions of the invention to elicit a response that controls not only the primary tumor but also any metastatic cells or metastatic tumors which subsequently arise.

US Patent:

20060228326, Oct 12, 2006

Filed:

Oct 21, 2003

Appl. No.:

10/532551

Inventors:

Isaiah Fidler - Houston TX, US
Zhongyun Dong - Sugar Land TX, US
Weixin Lu - Houston TX, US

International Classification:

A61K 38/21
A61K 38/20
A61K 38/19
C12P 21/02
C12N 5/06

US Classification:

424085100, 424085200, 424085500, 424085600, 424085700, 435069500, 435348000

Abstract:

The present invention provides for the treatment of a subject with occult brain metastasis. The treatment relies on administering to the subject a composition comprising an immunomodulatory polypeptide and a baculovirus-insect cell preparation. This composition has a unique ability to generate an anti-tumor immune response that is able to cross the blood-brain barrier.