Wenbin X Dang

US Patent:

6350464, Feb 26, 2002

Filed:

Jan 11, 1999

Appl. No.:

09/227852

Inventors:

Wenbin Dang - Ellicott City MD

Assignee:

Guilford Pharmaceuticals, Inc. - Baltimore MD

International Classification:

A61F 202

US Classification:

424426, 5147723

Abstract:

Biodegradable polymer compositions suitable for intraperitoneal administration to treat a mammalian subject having ovarian cancer are described, wherein the polymer compositions provide extended release of the antineoplastic agent into the peritoneum of the subject. The subject compositions can increase the median survival rate from the cancer by at least about 10%, as compared with the median survival rate obtained by administration of a composition comprising the same dosage of the antineoplastic agent without the biodegradable polymer. Solid articles and methods for treating ovarian cancer are also described.

US Patent:

6403675, Jun 11, 2002

Filed:

Apr 30, 1998

Appl. No.:

09/070204

Inventors:

Wenbin Dang - Ellicott City MD
Hai-quan Mao - Towson MD
Irina Kadiyala - Baltimore MD
Kam W. Leong - Ellicott City MD
Zhong Zhao - Ellicott City MD
James P. English - Chelsea AL

Assignee:

Guilford Pharmaceuticals, Inc. - Baltimore MD
Johns Hopkins University - Baltimore MD

International Classification:

A61K 3180

US Classification:

523113, 523111, 523124, 524610, 528359, 528356, 528400, 424486, 424 7808, 623 1

Abstract:

Biodegradable, flowable or flexible polymer compositions are described comprising a polymer having the recurring monomeric units shown in formula I: wherein: each of R and Râ is independently straight or branched alkylene, either unsubstituted or substituted with one or more non-interfering substituents; L is a divalent cycloaliphatic group; Râ is selected from the group consisting of H, alkyl, alkoxy, aryl, aryloxy, heterocyclic or heterocycloxy; and n is 5 to 1,000, wherein said biodegradable polymer is biocompatible before and upon biodegradation. In one embodiment, one or more of R, Râ or Râ is a biologically active substance. Amorphous compositions containing a biologically active substance, in addition to the polymer, and methods for controllably releasing biologically active substances using the compositions, are also described.

US Patent:

6479067, Nov 12, 2002

Filed:

Mar 28, 2001

Appl. No.:

09/819376

Inventors:

Wenbin Dang - Ellicott City MD

Assignee:

Guilford Pharmaceuticals, Inc. - Baltimore MD

International Classification:

A61F 202

US Classification:

424426, 424422, 424486, 424423, 5147723

Abstract:

Biodegradeable polymer compositions suitable for intraperitoneal administration to treat a mammalian subject having ovarian cancer are described, wherein the polymer compositions provide extended release of the antineoplastic agent into the peritoneum of the subject. The subject compositions can increase the median survival rate from the cancer by at least about 10%, as compared with the median survival rate obtained by administration of a composition comprising the same dosage of the antineoplastic agent without the biodegradeable polymer. Solid articles and methods for treating ovarian cancer are also described.

US Patent:

6485737, Nov 26, 2002

Filed:

Nov 27, 2000

Appl. No.:

09/722848

Inventors:

Hai-quan Mao - Towson MD
Kam W. Leong - Ellicott City MD
Zhong Zhao - Ellicott City MD
Wenbin Dang - Ellicott City MD
James P. English - Chelsea AL
David P. Nowotnik - Kingsville MD

Assignee:

Guilford Pharmaceuticals, Inc. - Baltimore MD

International Classification:

A61F 202

US Classification:

424426, 424501, 5147723, 428402

Abstract:

A medical device is described comprising a biodegradable terephthalate copolymer comprising the recurring monomeric units shown in formula I: wherein R is a divalent organic moiety; Râ is an aliphatic, aromatic or heterocyclic residue; x is 1; and n is 3-7, 500, where the biodegradable polymer is sufficiently pure to be biocompatible and is capable of forming biocompatible residues upon biodegradation. Compositions containing the copolymers and biologically active substances, articles useful for implantation or injection into the body fabricated from the compositions, and methods for controllably releasing biologically active substances using the copolymers, are also described.

US Patent:

6600010, Jul 29, 2003

Filed:

Aug 2, 2001

Appl. No.:

09/921297

Inventors:

Hai-Quan Mao - Towson MD
Kam W. Leong - Ellicott City MD
Wenbin Dang - Baltimore MD
Hungnan Lo - Shaker Heights OH
Zhong Zhao - Baltimore MD
David P. Nowotnik - Kingsville MD
James P. English - Chelsea AL

Assignee:

Guilford Pharmaceuticals, Inc. - Baltimore MD
John Hopkins University - Baltimore MD

International Classification:

C08G 7902

US Classification:

528400, 528398, 606278, 523115, 442248, 428378, 424271, 424426

Abstract:

Biodegradable terephthalate polymers are described comprising the recurring monomeric units shown in formula I: wherein R is a divalent organic moiety; Râ is an aliphatic, aromatic or heterocyclic residue; x is 1; and n is 0-5,000, wherein the biodegradable polymer is biocompatible before and upon biodegradation. Processes for preparing the polymers, compositions containing the polymers and biologically active substances, articles useful for implantation or injection into the body fabricated from the compositions, and methods for controllably releasing biologically active substances using the polymers, are also described.

US Patent:

6641833, Nov 4, 2003

Filed:

Oct 4, 2002

Appl. No.:

10/264793

Inventors:

Wenbin Dang - Belle Mead NJ

Assignee:

Guilford Pharmaceuticals, Inc. - Baltimore MD

International Classification:

A61F 202

US Classification:

424426, 424422, 424486, 424423, 5147723

Abstract:

Biodegradable polymer compositions suitable for intraperitoneal administration to treat a mammalian subject having ovarian cancer are described, wherein the polymer compositions provide extended release of the antineoplastic agent into the peritoneum of the subject. The subject compositions can increase the median survival rate from the cancer by at least about 10%, as compared with the median survival rate obtained by administration of a composition comprising the same dosage of the antineoplastic agent without the biodegradable polymer. Solid articles and methods for treating ovarian cancer are also described.

US Patent:

6800672, Oct 5, 2004

Filed:

Dec 4, 2001

Appl. No.:

10/011570

Inventors:

Wenbin Dang - Ellicott City MD
Irina Kadiyala - Baltimore MD
Zhong Zhao - Ellicott City MD
James P. English - Chelsea AL
Hai-quan Mao - Towson MD
Kam W. Leong - Ellicott City MD

Assignee:

Guilford Pharmaceuticals, Inc. - Baltimore MD
Johns Hopkins University School of Medicine - Baltimore MD

International Classification:

A61K 3180

US Classification:

523113, 523111, 523124, 524610, 528356, 528359, 528400, 623 1, 424 7808, 424486

Abstract:

Biodegradable, flowable or flexible polymer compositions are described comprising a polymer having the recurring monomeric units shown in formula I: wherein: each of R and Râ is independently straight or branched alkylene, either unsubstituted or substituted with one or more non-interfering substituents; L is a divalent cycloaliphatic group; Râ is selected from the group consisting of H, alkyl, alkoxy, aryl, aryloxy, heterocyclic or heterocycloxy; and n is 5 to 1,000, wherein said biodegradable polymer is biocompatible before and upon biodegradation. In one embodiment, one or more of R, Râ or Râ is a biologically active substance. Amorphous compositions containing a biologically active substance, in addition to the polymer, and methods for controllably releasing biologically active substances using the compositions, are also described.

US Patent:

7101568, Sep 5, 2006

Filed:

Feb 3, 2003

Appl. No.:

10/357292

Inventors:

Wenbin Dang - Belle Mead NJ, US
Robert Garver, Jr. - Hoover AL, US

Assignee:

Guilford Pharmaceuticals, Inc. - Baltimore MD

International Classification:

A61F 2/02
A61F 9/50
A61F 47/30

US Classification:

424426, 424501, 424502, 5147723

Abstract:

A biodegradable polymer composition comprising:.