Songzhu An - San Carlos CA, Jin-Long Chen - San Mateo CA, Hui Tian - Foster City CA, Wendy Wen Zhong - Daly City CA,
Amgen, Inc. - Thousand Oaks CA
435 721, 436501
The invention provides natural ligands of TGR183 receptors and methods of identifying modulators of various TGR183 receptors using the ligands. Methods of using the modulators to treat diseases or disorders associated with dysfunction of the TGR183 receptor are also provided.