Wenhui Hu from 224 Europa Ct, Cherry Hill, NJ 08003, age 61, Phone: (856)8571668

Use Of Nibp Polypeptides
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US Patent:

20120258539, Oct 11, 2012
Filed:

Oct 12, 2010
Appl. No.:

13/499932
Inventors:

Wenhui Hu - Cherry Hill NJ, US
Assignee:

Temple University of the Commonwealth of Higher Education Office of Technology Transfer - Philadelphia PA
International Classification:

C12N 15/85
C12N 5/10
US Classification:

435455, 435325
Abstract:

Methods for regulating NF-κB activation in cells comprising introducing into the cell a vector comprising a nucleic acid sequence encoding a NIK and IKK2 Binding Protein (NIBP) polypeptide, wherein the NIBP polypeptide is expressed in the cell, are provided. Also provided are methods for reversing the cancerous phenotype of a cancer cell and for modulating neuronal differentiation.

Methods And Compositions For Rna-Guided Treatment Of Hiv Infection
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US Patent:

20220313795, Oct 6, 2022
Filed:

May 24, 2021
Appl. No.:

17/329137
Inventors:

- Philadelphia PA, US
Wenhui Hu - Cherry Hill NJ, US
International Classification:

A61K 38/46
C12N 15/11
A61K 48/00
A61K 9/00
A61K 35/12
A61K 45/06
C12N 7/00
C12N 9/22
Abstract:

A method of preventing transmission of a retrovirus from a mother to her offspring, by administering to the mother a therapeutically effective amount of a composition comprising a Clustered Regularly Interspaced Short Palindromic Repeat (CRISPR)-associated endonuclease, and the two or more different multiplex gRNAs, wherein each of the at least two gRNAs is complementary to a different target nucleic acid sequence in a long terminal repeat (LTR) of proviral DNA of the virus that is unique from the genome of the host cell, cleaving a double strand of the proviral DNA at a first target protospacer sequence with the CRISPR-associated endonuclease, cleaving a double strand of the proviral DNA at a second target protospacer sequence with the CRISPR-associated endonuclease, excising an entire HIV-1 proviral genome, eradicating the HIV-1 proviral DNA from the host cell, and preventing transmission of the proviral DNA to the offspring.

Rna Guided Eradication Of Human Jc Virus And Other Polyomaviruses
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US Patent:

20230001016, Jan 5, 2023
Filed:

Apr 22, 2022
Appl. No.:

17/727438
Inventors:

- Philadelphia PA, US
Wenhui Hu - Cherry Hill NJ, US
Hassen Wollebo - Philadelphia PA, US
International Classification:

A61K 48/00
C12N 9/22
C12N 15/63
C12N 15/113
Abstract:

The present invention includes methods and compositions for elimination of polyomaviruses, such as John Cunningham Virus (JVC), from host cells, and the treatment of polyomavirus related diseases, such as progressive multifocal leukoencephalopathy (PML). The compositions include isolated nucleic acid sequences comprising an CRISPR-associated endonuclease and a guide RNA, wherein the guide RNA is complementary to a target sequence in a polyomavirus.

Methods And Compositions For Rna-Guided Treatment Of Hiv Infection
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US Patent:

20210252114, Aug 19, 2021
Filed:

Oct 13, 2020
Appl. No.:

17/068999
Inventors:

- Philadelphia PA, US
Wenhui Hu - Cherry Hill NJ, US
International Classification:

A61K 38/46
C12N 15/11
A61K 48/00
A61K 9/00
A61K 35/12
A61K 45/06
C12N 7/00
C12N 9/22
Abstract:

A method of preventing transmission of a retrovirus from a mother to her offspring, by administering to the mother a therapeutically effective amount of a composition comprising a Clustered Regularly Interspaced Short Palindromic Repeat (CRISPR)-associated endonuclease, and the two or more different multiplex gRNAs, wherein each of the at least two gRNAs is complementary to a different target nucleic acid sequence in a long terminal repeat (LTR) of proviral DNA of the virus that is unique from the genome of the host cell, cleaving a double strand of the proviral DNA at a first target protospacer sequence with the CRISPR-associated endonuclease, cleaving a double strand of the proviral DNA at a second target protospacer sequence with the CRISPR-associated endonuclease, excising an entire HIV-1 proviral genome, eradicating the HIV-1 proviral DNA from the host cell, and preventing transmission of the proviral DNA to the offspring.

Methods And Compositions For Rna-Guided Treatment Of Hiv Infection
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US Patent:

20210069303, Mar 11, 2021
Filed:

May 14, 2020
Appl. No.:

16/874295
Inventors:

- Philadelphia PA, US
Wenhui Hu - Cherry Hill NJ, US
International Classification:

A61K 38/46
C12N 15/11
A61K 48/00
A61K 9/00
A61K 35/12
A61K 45/06
C12N 7/00
C12N 9/22
Abstract:

A method of preventing transmission of a retrovirus from a mother to her offspring, by administering to the mother a therapeutically effective amount of a composition comprising a Clustered Regularly Interspaced Short Palindromic Repeat (CRISPR)-associated endonuclease, and the two or more different multiplex gRNAs, wherein each of the at least two gRNAs is complementary to a different target nucleic acid sequence in a long terminal repeat (LTR) of proviral DNA of the virus that is unique from the genome of the host cell, cleaving a double strand of the proviral DNA at a first target protospacer sequence with the CRISPR-associated endonuclease, cleaving a double strand of the proviral DNA at a second target protospacer sequence with the CRISPR-associated endonuclease, excising an entire HIV-1 proviral genome, eradicating the HIV-1 proviral DNA from the host cell, and preventing transmission of the proviral DNA to the offspring.

Methods And Compositions For Rna-Guided Treatment Of Hiv Infection
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US Patent:

20210052709, Feb 25, 2021
Filed:

Sep 10, 2020
Appl. No.:

17/017037
Inventors:

- Philadelphia PA, US
Wenhui HU - Cherry Hill NJ, US
Yonggang ZHANG - Maple Shade NJ, US
International Classification:

A61K 38/46
C12N 15/113
A61K 48/00
A61P 31/18
C12N 9/22
C12N 15/11
C12N 15/90
Abstract:

Compositions for specifically cleaving target sequences in retroviruses include nucleic acids encoding a Clustered Regularly Interspace Short Palindromic Repeat (CRISPR) associated endonuclease and a guide RNA sequence complementary to one or more target nucleic acid sequences in a retrovirus genome.

Excision Of Retroviral Nucleic Acid Sequences
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US Patent:

20200392487, Dec 17, 2020
Filed:

Jul 10, 2020
Appl. No.:

16/926427
Inventors:

- Philadelphia PA, US
Wenhui Hu - Cherry Hill NJ, US
International Classification:

C12N 15/11
A61K 48/00
C12N 9/22
C12N 15/113
Abstract:

Compositions for the in vivo delivery of a gene editing CRISPR/Cas9 complex was developed to eliminate integrated retroviral DNA sequences from latently infected human cells and animal disease models

Methods And Compositions For Rna-Guided Treatment Of Hiv Infection
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US Patent:

20190367910, Dec 5, 2019
Filed:

Sep 23, 2016
Appl. No.:

15/764119
Inventors:

- Philadelphia PA, US
Wenhui Hu - Cherry Hill NJ, US
International Classification:

C12N 15/11
C12N 9/22
A61K 35/17
C12N 15/90
A61P 31/18
Abstract:

The present disclosure provides compositions and methods for specific cleavage of target sequences in retroviruses, for example human immunodeficiency virus (HV-1). The compositions, which can include nucleic acids encoding a Clustered Regularly Interspace Short Palindromic Repeat (CRISPR) associated endonuclease and a guide RNA sequence complementary to a target sequence in a human immunodeficiency virus, can be delivered to the cells of a subject having or at risk for contracting an HV infection.