William D Abrams

US Patent:

20070053934, Mar 8, 2007

Filed:

Aug 25, 2006

Appl. No.:

11/510493

Inventors:

Neville Kallenbach - Philadelphia PA, US
Daniel Malamud - New York NY, US
Zhigang Liu - New York NY, US
William Abrams - Merion Station PA, US
Paramjit Arora - New York NY, US

International Classification:

A61K 31/70
A61K 39/12
A01N 43/04

US Classification:

424204100, 514044000

Abstract:

The invention is directed to compositions comprising polyvalent complexes containing a biocompatible polymer backbone to which is attached a plurality of monomeric anti-microbial peptides and to methods for using such complexes to stabilize anti-microbial peptides for treating or preventing a disease or condition resulting from infection with a microbe. Multivalent derivatives of existing antimicrobial peptides in which several peptides are covalently linked have been investigated. The resulting construct may contain up to 30 or more units, and exhibits a significant enhancement of anti-microbial effect relative to the free peptides: on the order of a ten fold improvement in effectiveness, suggesting that higher multimerization can indeed lead to more effective agents. The invention is also directed to the use of such complexes for delivery of anti-viral peptides, in particular, peptides and peptide fragments obtained from salivary agglutinin protein (gp-340) for use in treating or preventing infection with HIV.

US Patent:

20080280285, Nov 13, 2008

Filed:

Nov 9, 2007

Appl. No.:

11/937975

Inventors:

Zongyuan G. Chen - Philadelphia PA, US
Jing Wang - Upper Darby PA, US
Michael Mauk - Wilmington DE, US
Haim H. Bau - Swarthmore PA, US
Daniel Malamud - New York NY, US
William Abrams - Merion PA, US
Raymond Niedbala - Alletown PA, US
Hendrikus Johannes Tanke - Rijnsburg, NL
Paul L.A.M. Corstjens - Leiderdorp, NL

International Classification:

C12Q 1/70
B01J 19/00
C12M 1/40
C12Q 1/04
C12Q 1/68
C12P 19/34
C12M 1/34
G01N 30/00
C12M 1/33
G01N 33/536
G01N 33/00

US Classification:

435 5, 422 681, 4352891, 435 34, 435 6, 435 912, 422 70, 4353061, 436536, 436 94, 436 86, 4352885, 4352872

Abstract:

Disclosed are methods, devices and systems for biological and chemical sample processing using microfluidic chips. The disclosed microfluidic chips contain at least two detection zones for interacting with pre-selected RNA sequences, DNA sequences, antibodies, or antigens to determine their presence in the sample. Systems are also described comprising a cassette having at least one port and a sample inlet in fluid communication with a detection zone for interacting with pre-selected RNA sequences, DNA sequences, antibodies, or antigens, or mixtures thereof, if present, in a sample. Methods for concurrent testing of at least two of RNA, DNA, antibody, and antigen in a sample are also described, as are methods for testing for pre-selected pathogens and microfluidic methods.

US Patent:

20090186357, Jul 23, 2009

Filed:

Dec 10, 2008

Appl. No.:

12/331508

Inventors:

Michael G. Mauk - Greenville DE, US
Haim H. Bau - Swarthmore PA, US
Daniel Malamud - New York NY, US
William Abrams - Merion PA, US

Assignee:

THE TRUSTEES OF THE UNIVERSITY OF PENNSYLVANIA - Philadelphia PA

International Classification:

C12Q 1/68
C12M 1/34

US Classification:

435 6, 4352872

Abstract:

Disclosed are integrated devices capable of performing a polymerase chain reaction within a single vessel. Also disclosed are related methods of sample analysis.

US Patent:

62876058, Sep 11, 2001

Filed:

Apr 16, 1999

Appl. No.:

9/293758

Inventors:

Daniel Malamud - Merion PA
Thandavarayan Nagashunmugam - Havertown PA
Harvey M. Friedman - Merion PA
William Abrams - Merion PA
Earl J. Bergey - South Dayton NY

Assignee:

The Trustees of the University of Pennsylvania - Philadelphia PA

International Classification:

A61K 3537

US Classification:

424550

Abstract:

The invention includes compositions comprising substantially purified salivary glycoproteins and carbohydrate ligands thereof which are useful in methods for the treatment and prevention of HIV-1 infection. The invention also includes methods for the treatment and prevention of HIV-1 infection comprising contacting a composition of the invention with a human patient. Additionally, the invention includes antibodies and kits useful in the treatment and prevention of HIV-1 infection.

US Patent:

45247153, Jun 25, 1985

Filed:

Mar 30, 1983

Appl. No.:

6/480322

Inventors:

William C. Abrams - Cranford NJ

International Classification:

B05C 108
B05C 116

US Classification:

118221

Abstract:

An apparatus is disclosed for applying a coating material to a sheet material which is particularly useful in connection with preventing evaporation or drying out of the coating material when the apparatus is not in use. The apparatus basically includes a reservoir for containing a supply of coating material and an applicator roll having an applicator surface or surfaces thereon which is rotatably mounted in the reservoir so that coating material is received by the applicator surfaces and applied to the sheet material which is placed in contact therewith during rotation of the applicator roll. In accordance with one aspect, the applicator roll includes a plurality of substantially cylindrical applicator surfaces along the length thereof separated by a plurality of grooves, and a deflector device is provided having protruding portions disposed in the grooves of the applicator roll to cause the sheet material in contact with the applicator roll to separate from the applicator roll and be moved onto raised surface portions of the deflector device, the raised surface portions being such as to prevent contact of the coated surface of the sheet material with the downstream surface of the apparatus as the sheet material leaves the applicator roll. In accordance with other aspects of the apparatus, devices for sealing the reservoir and applicator roll from exposure to the surrounding atmosphere are provided. Additionally, a doctor blade mechanism for controlling the thickness of coating material received on the applicator roll during rotation is disclosed by which the position of the doctor blade with respect to the applicator surface of the applicator roll may be adjusted from a location displaced from the path of movement of a sheet material being fed to the applicator roll.

US Patent:

20170096702, Apr 6, 2017

Filed:

Sep 8, 2016

Appl. No.:

15/259416

Inventors:

- Philadelphia PA, US
William R. Abrams - Merion PA, US
Eran Geva - Brooklyn NY, US
Michael G. Mauk - Wilmington DE, US
Changchun Liu - Bala Cynwyd PA, US
Daniel Malamud - New York NY, US
Xianbo Qiu - Philadelphia PA, US

International Classification:

C12Q 1/68
B01L 7/00

Abstract:

Provided are devices adapted to isolate, amplify, and detect nucleic acids that may be present in a biological sample. The devices can, in some embodiments, isolate, amplify, and detect nucleic acid in a single chamber. In other embodiments, the devices are adapted to isolate and amplify nucleic acids in a reaction chamber, after which the nucleic acids may be communicated to a pervious medium—such as a lateral flow strip—where the user may label and detect the nucleic acids.

US Patent:

20140162244, Jun 12, 2014

Filed:

Feb 15, 2012

Appl. No.:

14/001347

Inventors:

Haim H. Bau - Swarthmore PA, US
William R. Abrams - Merion PA, US
Eran Geva - Brooklyn NY, US
Michael G. Mauk - Greenville DE, US
Changchun Liu - Bala Cynwyd PA, US
Daniel Malamud - New York NY, US
Xianbo Ceiu - Beijing, CN

International Classification:

C12Q 1/70

US Classification:

435 5, 4352872

Abstract:

Provided are devices adapted to isolate, amplify, and detect nucleic acids that may be present in a biological sample. The devices can, in some embodiments, isolate, amplify, and detect nucleic acid in a single chamber. In other embodiments, the devices are adapted to isolate and amplify nucleic acids in a reaction chamber, after which the nucleic acids may be communicated to a pervious medium—such as a lateral flow strip—where the user may label and detect the nucleic acids.