William F Barth

US Patent:

20220192177, Jun 23, 2022

Filed:

Dec 17, 2021

Appl. No.:

17/553999

Inventors:

- Boston MA, US
- Cambridge MA, US
Jeffrey N. Stout - Jamaica Plain MA, US
Lawrence L. Wald - Cambridge MA, US
Elfar Adalsteinsson - Belmont MA, US
William Barth - Boston MA, US

Assignee:

Children's Medical Center Corporation - Boston MA
Massachusetts Institute of Technology - Cambridge MA
The General Hospital Corporation - Boston MA

International Classification:

A01N 1/02
A61B 5/055
G01R 33/30
G01R 33/58

Abstract:

Provided herein are systems and methods for development and use of a perfusion apparatus comprising a biological phantom created from an ex vivo placenta. In some embodiments, a system is provided for perfusing an ex vivo placenta to be imaged using a magnetic resonance imaging (MRI) device, the system comprising a chamber configured to house the ex vivo placenta therein, the chamber including a first partition separating the chamber into a first portion and a second portion, wherein the ex vivo placenta is housed at least partially in the first portion, and at least one first inlet disposed in the second portion for receiving at least one first tube, the at least one first tube being configured to couple at least one first pump to a fetal compartment of the ex vivo placenta when present in the chamber.