Corinna Herrnstadt - San Diego CA Soumitra S. Ghosh - San Diego CA William Clevenger - San Diego CA Eoin D. Fahy - San Diego CA Robert E. Davis - San Diego CA
Assignee:
Mitokor - San Diego CA
International Classification:
C07H 2102
US Classification:
536 231, 536 241, 536 243, 435 6
Abstract:
Compositions and methods based on quantification of extramitochondrial DNA (exmtDNA) sequences are provided that are useful for detecting the presence of or risk for having a disease associated with altered mitochondrial function, and for identifying agents suitable for treating such diseases. The exmtDNA sequences have strong homology to authentic mitochondrial DNA (mtDNA) sequences.
Diagnostic Method Based On Quantification Of Extramitochondrial Dna
Corinna Herrnstadt - San Diego CA Soumitra S. Ghosh - San Diego CA William Clevenger - Vista CA Eoin D. Fahy - San Diego CA Robert E. Davis - San Diego CA
Compositions and methods based on quantification of extramitochondrial DNA (exmtDNA) sequences are provided that are useful for detecting the presence of or risk for having a disease associated with altered mitochondrial function, and for identifying agents suitable for treating such diseases. The exmtDNA sequences have strong homology to authentic mitochondrial DNA (mtDNA) sequences.
Compositions And Mehtods For Determining Interactions Of Mitochondrial Components, And For Identifying Agents That Alter Such Interactions
Anne N. Murphy - Encinitas CA William Clevenger - Oceanside CA Sandra Eileen Wiley - San Diego CA Alexander Y. Andreyev - San Diego CA Luciano G. Frigeri - San Diego CA Robert E. Davis - San Diego CA
Compositions and methods are provided for identifying agents that alter mitochondrial membrane permeability transition. The screening methods generally detect agents that alter the interaction between the mitochondrial adenine nucleotide translocator and cyclophilin D. Such agents may be used, for example, in the treatment of a variety of conditions associated with altered mitochondrial function.
Compositions And Methods For Determining Interactions Of Mitochondrial Components, And For Identifying Agents That Alter Such Interactions
Anne N. Murphy - Encinitas CA William Clevenger - Oceanside CA Sandra Eileen Wiley - San Diego CA Alexander Y. Andreyev - San Diego CA Luciano G. Frigeri - San Diego CA Gonul Velicelebi - San Diego CA Robert E. Davis - San Diego CA
Compositions and methods are provided for identifying agents that alter mitochondrial membrane permeability transition. The screening methods generally detect agents that alter the interaction between the mitochondrial adenine nucleotide translocator and cyclophilin D. Such agents may be used, for example, in the treatment of a variety of conditions associated with altered mitochondrial function.
Production Of Adenine Nucleotide Translocator (Ant), Novel Ant Ligands And Screening Assays Therefor
Christen M. Anderson - Encinitas CA, US Robert E. Davis - San Diego CA, US William Clevenger - Oceanside CA, US Sandra Eileen Wiley - San Diego CA, US Scott W. Miller - San Marcos CA, US Tomas R. Szabo - San Diego CA, US Soumitra S. Ghosh - San Diego CA, US Walter H. Moos - Oakland CA, US Yazhong Pei - San Diego CA, US
Compositions and methods are provided for producing adenine nucleotide translocator (ANT) polypeptides and fusion proteins, including the production and use of recombinant expression constructs having a regulated promoter. ANT ligands and compositions and methods for identifying ANT ligands, agents that bind ANT and agents that interact with ANT are also disclosed.
Production Of Adenine Nucleotide Translocator (Ant), Novel Ant Ligands And Screening Assays Therefor
Christen M. Anderson - Encinitas CA, US Robert E. Davis - San Diego CA, US William Clevenger - Vista CA, US Sandra Eileen Wiley - San Diego CA, US
Assignee:
Migenix Corp. - San Diego CA
International Classification:
C07K001/00 C07K014/00
US Classification:
530350, 435 691, 536 234, 536 231
Abstract:
Compositions and methods are provided for producing adenine nucleotide translocator (ANT) polypeptides and fusion proteins, including the production and use of recombinant expression constructs having a regulated promoter. ANT ligands and compositions and methods for identifying ANT ligands, agents that bind ANT and agents that interact with ANT are also disclosed.
Production Of Adenine Nucleotide Translocator (Ant), Novel Ant Ligands And Screening Assays Therefor
Compositions and methods are provided for producing adenine nucleotide translocator (ANT) polypeptides and fusion proteins, including the production and use of recombinant expression constructs having a regulated promoter. ANT ligands and compositions and methods for identifying ANT ligands, agents that bind ANT and agents that interact with ANT are also disclosed.
Production Of Adenine Nucleotide Translocator (Ant), Novel Ant Ligands And Screening Assays Therefor.
Christen M. Anderson - San Diego CA, US Robert E. Davis - San Diego CA, US William Clevenger - Oceanside CA, US Sandra Eileen Wiley - San Diego CA, US Scott W. Miller - San Marcos CA, US Tomas R. Szabo - San Diego CA, US Soumitra S. Ghosh - San Diego CA, US Walter H. Moos - Oakland CA, US Yazhong Pei - San Diego CA, US
Compositions and methods are provided for producing adenine nucleotide translocator (ANT) polypeptides and fusion proteins, including the production and use of recombinant expression constructs having a regulated promoter. ANT ligands and compositions and methods for identifying ANT ligands, agents that bind ANT and agents that interact with ANT are also disclosed.