William C Colwell

US Patent:

60280719, Feb 22, 2000

Filed:

Mar 8, 1999

Appl. No.:

9/214984

Inventors:

Francis M. Sirotnak - New York NY
James R. Piper - Birmingham AL
Joseph I. DeGraw - Missoula MT
William T. Colwell - Menlo Park CA

Assignee:

Sloan-Kettering Institute for Cancer Research - New York NY
SRI International - Menlo Park CA
Southern Research Institute - Birmingham AL

International Classification:

A61K 31505
C07D47508

US Classification:

514249

Abstract:

Highly purified 10-propargyl-10-deazaaminopterin (10-propargyl-10dAM) compositions tested in xenograft models for their efficacy against human tumors are shown to be far superior to methotrexate ("MTX") and are even superior to the newer clinical candidate edatrexate ("EDX"). Moreover, 10-propragyl-10dAM showed a surprising ability to cure tumors such that there was no evidence of tumor growth several weeks after the cessation of therapy. Thus, highly purified compositions containing 10-propargyl-10dAM can be used to treat human tumors, particularly human mammary tumors and human lung cancer.

US Patent:

43347304, Jun 15, 1982

Filed:

Nov 26, 1979

Appl. No.:

6/097459

Inventors:

William L. Colwell - Norwalk CT
Carl W. Schmelzle - Westport CT

Assignee:

Bunker Ramo Corporation - Oak Brook IL

International Classification:

H01R 1340

US Classification:

339130C

Abstract:

A coupling suited for insulated from ground mounting through an opening in a panel. The coupling includes an outer shell dimensioned and shaped to extend through the opening in the panel. The outer shell has an interruption in the outer surface thereof. The interruption is located intermediate the ends of the outer shell. An insulated mounting member is provided which is associated with the outer shell. The insulated mounting member is disposed intermediate the ends of the outer shell and is dimensioned and shaped such that at least a portion thereof extends through the opening in the panel. The insulated mounting member cooperates with the interruption so as to be in integral relationship with the outer shell. The coupling is suitably manufactured by molding the insulated mounting member about the outer shell. With these features of construction, the coupling is adapted for insulated from ground mounting through an opening in a panel.

US Patent:

63232057, Nov 27, 2001

Filed:

Feb 17, 2000

Appl. No.:

9/505571

Inventors:

Francis M. Sirotnak - New York NY
James R. Piper - Birmingham AL
Joseph I. DeGraw - Missoula MT
William T. Colwell - Menlo Park CA

Assignee:

Sloan-Kettering Institute for Cancer Research - New York NY
SRI International - Menlo Park CA
Southern Research Institute - Birmingham AL

International Classification:

A61K 31505

US Classification:

514249

Abstract:

Preliminary clinical studies in humans have now been done which show both the efficacy of 10-propargyl-10dAM and a preferred dosage schedule for such treatments. In addition, it has now been determined that combinations of 10-propargyl-10-deazaaminopterin (preferably highly purified forms, substantially free of 10-deazaaminopterin) with taxols exhibit synergistic effectiveness in the treatment of tumors. 10-propargyl-10-deazaaminopterin and a taxol in therapeutically effective amounts can be administered concurrently, one right after the other, or with a period of time in between.