William D Colwell

US Patent:

48187534, Apr 4, 1989

Filed:

Sep 18, 1987

Appl. No.:

7/098499

Inventors:

William T. Colwell - Menlo Park CA
Joseph I. DeGraw - Sunnyvale CA

Assignee:

SRI International - Menlo Park CA

International Classification:

A61K 31505
C07D23995

US Classification:

514155

Abstract:

Compounds of the formula ##STR1## wherein R. sup. 1 is H, methyl, ethyl, or chloro and R. sup. 2 is hydrocarbyl of 1-12 C are useful as antifungal agents. Compounds of this series wherein R. sup. 2 is 7-12 C are novel. A new synthetic method for the compounds is also described.

US Patent:

53547519, Oct 11, 1994

Filed:

Jul 12, 1993

Appl. No.:

8/090750

Inventors:

Joseph I. DeGraw - Sunnyvale CA
William T. Colwell - Menlo Park CA
Francis M. Sirotnak - New York NY
R. Lane Smith - Palo Alto CA
James R. Piper - Birmingham AL

Assignee:

SRI International - Menlo Park CA

International Classification:

A61K 31505

US Classification:

514249

Abstract:

There is disclosed certain heteroaroyl 10-deazaaminopterin and 5, 10 and 8, 10 di deazaminopterin compounds and their use for treatment of rheumatoid arthritis and related diseases and preparative process. Also disclosed are 10 alkenyl-(and alkynyl) 10-deazaminopterins also disclosed for treatment of rheumatoid arthritis and for leukemia and ascites tumors and preparative process.

US Patent:

55367240, Jul 16, 1996

Filed:

Oct 21, 1993

Appl. No.:

8/140793

Inventors:

Joseph I. DeGraw - Sunnyvale CA
William T. Colwell - Menlo Park CA
Francis M. Sirotnak - New York NY
R. Lane Smith - Palo Alto CA
James R. Piper - Birmingham AL

Assignee:

SRI International - Menlo Park CA
Sloan-Kettering Institute - New York NY

International Classification:

A61K 31505
C07D47104
C07D33338
C07D21381

US Classification:

514258

Abstract:

Antiinflammatory and antineoplastic 5-deazaaminopterins and 5,10-dideazaaminopterins and their 5 and 10 alkyl analogs. A method for the treatment and prevention of inflammatory disease, such as rheumatoid arthritis, and for suppression and prevention of neoplastic growth in tumors and in blood forming tissues. A process for preparation of 10-deazaaminopterins.

US Patent:

53747267, Dec 20, 1994

Filed:

Mar 9, 1993

Appl. No.:

8/028431

Inventors:

Joseph I. DeGraw - Sunnyvale CA
William T. Colwell - Menlo Park CA
James R. Piper - Birmingham AL

International Classification:

C07D47508

US Classification:

544260

Abstract:

A process is provided for the preparation of 10-deazaaminopterins and 5,10- and 8,10-dideazaaminopterins starting from the corresponding homoterephthalic acid diester coupling the corresponding dicarboxylic acid diester having the formula: ##STR1## with the corresponding diaminopterin 6-methylene halide having the formula: ##STR2## thereby forming a pteroic acid diester having the formula: ##STR3## hydrolysing the two ester groups to form the corresponding carboxylic acid groups, and then monodecarboxylating the diacid, thereby removing the carboxylic acid group attached to the carbon alpha to the A group and forming a pteroic acid.

US Patent:

51679639, Dec 1, 1992

Filed:

Jul 27, 1990

Appl. No.:

7/558923

Inventors:

Joseph I. DeGraw - Sunnyvale CA
William T. Colwell - Menlo Park CA
Francis M. Sirotnak - New York NY

Assignee:

SRI International - Menlo Park CA
Sloan-Kettering Institute for Cancer Research - New York NY

International Classification:

A61K 902
A61K 964
A61K 31495
C07D47104

US Classification:

424436

Abstract:

8,10-Dideazatetrahydrofolic acid derivatives of the formula: ##STR1## where R. sub. 1 and R. sub. 2 are selected from hydrogen and alkyl having from one to about eight carbon atoms and the carboxylates and acid addition salts thereof, showing strong inhibition of L1210 murine leukemia cells in culture, modest inhibition of glycinamide ribotide transformylase and aminoimidazole carboxamide ribotide transferase, and insignificant inhibition of dihydrofolate reductase and thymidylate synthase enzymes.

US Patent:

20150032511, Jan 29, 2015

Filed:

Jul 22, 2014

Appl. No.:

14/337717

Inventors:

- San Mateo CA, US
William Colwell - San Mateo CA, US

Assignee:

PECABU, INC. - San Mateo CA

International Classification:

G06Q 30/02

US Classification:

705 734

Abstract:

In some embodiments, a non-transitory processor-readable medium stores code representing instructions to be executed by a processor that can cause the processor to receive from mobile compute devices demographic information associated with users of such mobile compute devices and the indication of the locations of such mobile compute devices and the time. The code causes the processor to identify based on the indication of the location and the time, a collection of mobile compute devices that are within a geographic area during a time period. The code causes the processor to receive from a remote sensory device, environmental information associated with the geographical area during the time period. The code causes the processor to correlate the demographic information with the environmental information to define a trend associated with the geographic area and the time period and send a signal including an indicator associated with the trend.

US Patent:

20150032541, Jan 29, 2015

Filed:

Jul 22, 2014

Appl. No.:

14/337729

Inventors:

- San Mateo CA, US
William Colwell - San Mateo CA, US

Assignee:

Pecabu, Inc. - San Mateo CA

International Classification:

G06Q 30/02

US Classification:

705 1457

Abstract:

In some embodiments, a non-transitory processor-readable medium stores code representing instructions to be executed by a processor that causes the processor to receive historical demographic and historical environmental information associated with a geographic location and a recurring time period. The code causes the processor to select a first set of advertisements for the geographic location and the recurring time period based on the historical demographic and the historical environmental information. The code causes the processor to receive current demographic and current environmental information associated with the geographic location and a current time period associated with the recurring time period. The code causes the processor to send an instruction to present the first set of advertisements to a device at the geographical location and during the current time period if the current demographic and the current environmental information are substantially similar to the historical demographic and the historical environmental information.