William Forrest Dixon

US Patent:

20020147197, Oct 10, 2002

Filed:

Mar 20, 2002

Appl. No.:

10/104549

Inventors:

Michael Newman - San Diego CA, US
William Dixon - La Jolla CA, US

International Classification:

A61K031/5377
A61K031/454
A61K031/4178

US Classification:

514/235800, 514/254050, 514/326000, 514/396000, 514/397000, 514/400000

Abstract:

Improved methods are provided for therapeutic and/or preventative treatment to a mammal in which the mammal is protected against the toxicity of active pharmaceutical agents that (i) bind to or are substrates for P-gp, (ii) are taxane analogues, and/or (iii) are inhibitors of tubulin disassembly. Additionally provided are compositions and methods useful for treating cell proliferative disorders. Further provided are methods of increasing the bioavailability of therapeutic and/or preventative treatments in a mammal. Particular embodiments are directed to increasing such bioavailability across the blood-brain barrier.

US Patent:

20070203215, Aug 30, 2007

Filed:

Jan 25, 2007

Appl. No.:

11/627289

Inventors:

Michael Newman - San Diego CA, US
William Dixon - La Jolla CA, US

Assignee:

Taiji Biomedical, Inc. - Menlo Park CA

International Classification:

A61K 31/417

US Classification:

514400000

Abstract:

Improved methods are provided for therapeutic and/or preventative treatment to a mammal in which the mammal is protected against the toxicity of active pharmaceutical agents that (i) bind to or are substrates for P-gp, (ii) are taxane analogues, and/or (iii) are inhibitors of tubulin disassembly. Additionally provided are compositions and methods useful for treating cell proliferative disorders. Further provided are methods of increasing the bioavailability of therapeutic and/or preventative treatments in a mammal. Particular embodiments are directed to increasing such bioavailability across the blood-brain barrier.

US Patent:

60244135, Feb 15, 2000

Filed:

Sep 4, 1997

Appl. No.:

8/923160

Inventors:

William Dixon - San Diego CA
Ben M. Spencer - Seattle WA

Assignee:

Spencer Technology, Inc. - Richland WA

International Classification:

B60B 102

US Classification:

301 58

Abstract:

An impact resistant extrudable alloy spoked wheel having a rim with an integral transverse curved torque converter yolk portion integral with the rim side wall portions forming an angle of about 20 degrees to about 45 degrees with a horizontal plane and with a radius of curvature of about 0. 22 inches to about 0. 34 inches; including aluminum alloys, magnesium alloys, a titanium alloys, a beryllium alloys or mixtures thereof with ceramic particles selected from among alumina, silicon carbide, aluminum nitride, Boron carbide and silicon nitride.

US Patent:

62501275, Jun 26, 2001

Filed:

Oct 11, 1999

Appl. No.:

9/415698

Inventors:

Frank J. Polese - San Diego CA
Jack A. Rubin - San Diego CA
Michael J. Singer - San Marcos CA
Walter V. Chichra - Wappingers Fall NY
Anthony P. Grodio - Lagrangeville NY
Vlad Ocher - San Diego CA
Henry Escalante - San Diego CA
William Dixon - Escondido CA
David L. Rose - Cardiff CA
Stuart Weinshanker - San Diego CA

Assignee:

Polese Company, Inc. - CA

International Classification:

B21C 2300

US Classification:

72256

Abstract:

A process for low cost manufacturing light-weight, heat-dissipating structures such as heatsinks, heat spreaders, and covers or lids for microelectronic components such as flip-chip integrated circuits from difficult-to-machine metal matrix composites such as aluminum silicon carbide (generically referred to as "Al--SiC" or "AlSiC"). The process involves selecting a mass produced quantity of Al--SiC material, forming that material into a thin ribbon, then stamping/coining the ribbon into the structures. The ribbon can be formed by extruding a thin strip from a billet of the Al--SiC material, then plurally rolling it. In this way, commonly available AlSiC composites manufactured in high volume for use in other applications such as cast automotive parts may be used.