William H Ewing

US Patent:

D480815, Oct 14, 2003

Filed:

Aug 13, 2002

Appl. No.:

29/165712

Inventors:

William R. Ewing - Encinitas CA
Robert K. Neeper - Lakeside CA
Rhett L. Affleck - Poway CA
Gordon W. Hudson - Vista CA
John F. Bridwell - San Diego CA
John E. Lillig - Poway CA

Assignee:

Discovery Partners International - San Diego CA

International Classification:

2402

US Classification:

D24226, D24216, D24225

US Patent:

20040091941, May 13, 2004

Filed:

Aug 8, 2003

Appl. No.:

10/638275

Inventors:

William Ewing - Encinitas CA, US
Robert Neeper - Ramona CA, US
Rhett Affleck - Poway CA, US
John Lillig - Poway CA, US

International Classification:

G01N033/53
G01N033/543
B01J033/00

US Classification:

435/007100, 436/518000, 502/001000

Abstract:

A plurality of samples of different substances are tested for their ability to enhance or inhibit a biological process. The samples are deposited on a supporting surface, such as a ChemCard, in an array comprising at least two dots of each sample, wherein at least one of the dots of each sample is at least a predetermined distance from at least one of the dots of each of the plurality of samples. One or more assay reagents in a gel sheet, for example, are then brought in contact with the compounds and reactions with certain of the compounds are evident as the active compounds diffuse into the one or more assay reagents. The concept of having unique neighbors for each occurrence of a dot allows the definitive correlation of active compounds with the dot (and the compound) that caused the biological activity.

US Patent:

20040218804, Nov 4, 2004

Filed:

Jan 30, 2004

Appl. No.:

10/769150

Inventors:

Rhett Affleck - Poway CA, US
Robert Levin - San Diego CA, US
John Lillig - Ramona CA, US
Robert Neeper - Ramona CA, US
William Ewing - Encinitas CA, US
Duane DeSieno - La Jolla CA, US
Eric Hansen - San Luis Obispo CA, US
Mike Bodnar - San Diego CA, US

International Classification:

G06K009/00

US Classification:

382/141000

Abstract:

An image analysis system and related methods for automation of the monitoring of samples to determine crystal growth. Samples are imaged from time to time using a set of imaging parameters. The resulting images are evaluated to determine the contents of the samples. If the evaluation of the image indicates the presence of crystals, the sample may be re-imaged using a different set of imaging parameters, and the resulting image analyzed to determine its contents. The sample may also be evaluated by generating multiple images of a sample using various sets of imaging parameters, identifying pixels that depict regions of interest in a plurality of images, merging the pixels from each region of interest into a composite image and analyzing the composite image. An image of a sample can also be evaluated by classifying the pixels of the image based on the contents of the sample that they depict, color-coding the pixels using the classifications, and displaying the colored image for analysis.

US Patent:

20050008212, Jan 13, 2005

Filed:

Apr 8, 2004

Appl. No.:

10/822035

Inventors:

William Ewing - Encinitas CA, US
Duane DeSieno - La Jolla CA, US
Rhett Affleck - Poway CA, US

International Classification:

G06K009/00

US Classification:

382133000

Abstract:

A plurality of samples are tested for their ability to enhance or inhibit a biological process in a multiplexed diffusive assay. The assay is imaged after the biological process has produced spots in a medium that indicate the tested enhancing or inhibiting ability of the samples. The image containing the resulting spots are evaluated to determine which samples caused the spots to form. The location of spots are identified by user selection or through a gradient triangulation technique that determines spot locations by analyzing the slope of pixel intensities in numerous subimages. The spots may also be analyzed by parametrically modeling the spots and comparing the spot characteristics in the image to a spot function, to determine the location of hit spots in the image. The hit spot locations, corresponding to the location of tested samples in the assay that enhanced or inhibited the biological process, are output to facilitate further analysis of the test samples.

US Patent:

61362743, Oct 24, 2000

Filed:

Oct 7, 1997

Appl. No.:

8/958254

Inventors:

Michael P. Nova - Rancho Santa Fe CA
John E. Lillig - Poway CA
Kanchana Sanjaya Gunesekera Karunaratne - San Diego CA
Donald O'Neil - San Diego CA
William Ewing - San Diego CA
Yozo Satoda - San Diego CA

Assignee:

IRORI - San Diego CA

International Classification:

B01L 300

US Classification:

422102

Abstract:

Automated drug discovery protocols, or partially automated protocols, in which matrices-with-memories serve as the platform on which all manipulations are performed or serve as the repository of information that is transferred to other memories as the synthesized compounds are processed and screened. Also provided are automated drug discovery units for use in the protocols. The units provide for seamless data tracking and include instrumentation and vials with memories for information transfer to other memories in a unit. The units, which are provided herein, include some or all of the following: an automated or manual sorter, microreactors and microvessels, which contain memories, an automated or semi-automated synthesizer, a microreactor washer/dryer, a manual or automated cleaver with a valved U-tube outlet for removing compounds from the matrix-with-memory microreactors, and associated software. The memories may be any of any type, including electromagnetically encodable memories and optical memories, or combinations thereof. The memories may be pre-encoded or may be encodable during, after or before processing.

US Patent:

57197610, Feb 17, 1998

Filed:

Jan 15, 1993

Appl. No.:

8/005249

Inventors:

Joe D. Gatti - San Diego CA
William R. Ewing - San Diego CA

Assignee:

Alaris Medical Systems, Inc. - San Diego CA

International Classification:

G05B 1900

US Classification:

364130

Abstract:

A system for configuring a second biomedical device in the same configuration as a first device. The first device is configured as desired and then is connected through a communication link to the second device to be configured. A teach mode is invoked in the first device and a learn mode invoked in the second device. The first device receives identification data from the second device, such as the model number and software revision number. If acceptable, the first device compares individual parameters against default values. The first device then sends only those parameters which differ from the default values. The second device will then load these parameters plus the default value of the other parameters. Both devices will indicate a successful transfer of data by means of a display. If the identification data do not match, the first device will provide a prompt and no configuration data will be sent to the second device.

US Patent:

52400077, Aug 31, 1993

Filed:

May 14, 1991

Appl. No.:

7/700009

Inventors:

Kenneth J. Pytel - San Diego CA
Stephen A. Martin - Carlsbad CA
Robert D. Butterfield - Poway CA
William R. Ewing - San Diego CA

Assignee:

IVAC Corporation - San Diego CA

International Classification:

A61L 5021

US Classification:

128672

Abstract:

An artery applanation actuator for use in a system for noninvasively determining the intra-arterial blood pressure of a user incorporates a fluid actuator to effect movement of a sensor. The movement of the sensor is effective for applanating an artery of interest and measuring the stress of the tissue overlaying the artery of interest. Alternative embodiments of the artery applanation actuator are presented wherein an electric motor is used to activate a rotating arm which has a sensor located thereon. The rotation of the arm causes the sensor to contact and press against the tissue overlying the artery of interest. The artery applanation actuator is presented having a protective sheath surrounding the sensor to protect the sensor against inadvertent contact.

US Patent:

63291398, Dec 11, 2001

Filed:

Aug 11, 1997

Appl. No.:

8/912998

Inventors:

Michael P. Nova - Rancho Santa Fe CA
John E. Lillig - Alamo CA
Kanchana Sanjaya Gunesekera Karunaratne - San Diego CA
William Ewing - San Diego CA
Yozo Satoda - San Diego CA
Hanan Potash - Austin TX

Assignee:

Discovery Partners International - San Diego CA

International Classification:

C12Q 168

US Classification:

435 6

Abstract:

Automated drug discovery protocols, or partially automated protocols, in which matrices with memories serve as the platform on which all manipulations are performed or serve as the repository of information that is transferred to other memories as the synthesized compounds are processed and screened. Also provided are automated drug discovery units for use in the protocols. The units provide a means for seamless data tracking and include instrumentation and vials with memories for information transfer to other memories in a unit. The units, which are provided herein, include some or all of the following: an automated or manual sorter, microvessels, which contain memories, an automated or semi-automated synthesizer, a microvessel washer/dryer, a manual or automated cleaver for removing compounds from the matrix with memory microvessels, and associated software. The memories may be any of any type, including electromagnetically encodable memories and optical memories, or combinations thereof. The memories may be pre-encoded or may be encodabie during, after or before processing.